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T1R3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244011

TAS1R3 is a Taste Receptor. TAS1R3 combines with TAS1R1 to function as an L-amino-acid receptor, and is only activated by these sweet amino acids. More details

$630 / 0.05 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
T1R3 / TAS1R3, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human T1R3 / TAS1R3
Product Gene Name
anti-T1R3 antibody
Product Synonym Gene Name
TAS1R3
Product Synonym Names
Anti-T1R3 / TAS1R3 Antibody (N-Terminus) IHC-plus; TAS1R3; Taste receptor type 1 member 3; TR3; Sweet taste receptor T1R3; T1R3; Human T1R3; TAS1R3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Chimpanzee, Gorilla, Human
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human TAS1R3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
93,386 Da
OMIM
605865
3D Structure
ModBase 3D Structure for Q7RTX0
Target Species
Human
Immunogen Description
Synthetic 19 amino acid peptide from N-terminal extracellular domain of human TAS1R3. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Baboon (100%); Orangutan (89%).
Immunogen Type
Synthetic peptide
Immunogen
T1R3 / TAS1R3 antibody was raised against synthetic 19 amino acid peptide from N-terminal extracellular domain of human TAS1R3. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Baboon (100%); Orangutan (89%).
Antigen Modification
N-Terminus

Product Categories/Family for anti-T1R3 antibody

Family: GPCR; Subfamily: Taste
Applications Tested/Suitable for anti-T1R3 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-T1R3 antibody
IHC-P (10 - 20 ug/ml), WB

Immunohistochemistry (IHC) of anti-T1R3 antibody

Anti-T1R3 / TAS1R3 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-T1R3 Polyclonal Antibody – Cat# MBS244011

Immunohistochemistry (IHC) of anti-T1R3 antibody

Anti-T1R3 / TAS1R3 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-T1R3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244011

Immunohistochemistry (IHC) of anti-T1R3 antibody

Anti-TAS1R3 antibody IHC of human tongue, taste receptor. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-T1R3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244011

Other Notes

Small volumes of anti-T1R3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for T1R3 purchase

MBS244011 is an antibody targeting T1R3. Also known as Rabbit Polyclonal to Human T1R3 / TAS1R3. Reactive in Chimpanzee, Gorilla, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for T1R3. It may not necessarily be applicable to this product.

NCBI GI #
91206396
NCBI GeneID
83756
NCBI Accession #
NP_689414.1
UniProt Primary Accession #
Q7RTX0
UniProt Secondary Accession #
Q5TA49; Q8NGW9
UniProt Related Accession #
Q7RTX0
GenBank Nucleotide #
NM_152228.1
NCBI Official Full Name
taste receptor type 1 member 3
NCBI Official Synonym Full Names
taste receptor, type 1, member 3
NCBI Official Symbol
TAS1R3
NCBI Official Synonym Symbols
T1R3
UniProt Protein Name
Taste receptor type 1 member 3
UniProt Synonym Protein Names
Sweet taste receptor T1R3
UniProt Gene Name
TAS1R3
UniProt Synonym Gene Names
T1R3; TR3
UniProt Entry Name
TS1R3_HUMAN
NCBI Protein Information
taste receptor type 1 member 3; sweet taste receptor T1R3

NCBI Summary for T1R3

The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharine, and other sweeteners (Max et al., 2001 [PubMed 11326277]).[supplied by OMIM, Jan 2010]

UniProt Comments for T1R3

TAS1R3: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.

Protein type: Receptor, GPCR; GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: plasma membrane; integral to membrane

Molecular Function: protein heterodimerization activity; sweet taste receptor activity; taste receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; sensory perception of umami taste; sensory perception of sweet taste; detection of chemical stimulus involved in sensory perception of sweet taste
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Research Articles on T1R3

1. A complex molecular mechanism involving changes in the properties of both the orthosteric and non-orthosteric sites of T1R1 underlies the determination of ligand specificity in mammalian T1R1/T1R3.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-T1R3 antibody

 Reference Product  PubMed Publications
 TAS1R2 antibody  >22 publications with T1R3 and TAS1R2
 TAS1R1 antibody  >21 publications with T1R3 and TAS1R1
 GNAT3 antibody  >7 publications with T1R3 and GNAT3
 TAS2R38 antibody  >1 publications with T1R3 and TAS2R38

Pathways associated with anti-T1R3 antibody

 Products by Pathway  Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies  Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Taste Transduction Pathway antibodies  Taste Transduction Pathway Diagram

Diseases associated with anti-T1R3 antibody

 Disease Name  Pubmed Publications
 Hypoglycemia Antibodies  >1 publications with T1R3 and Hypoglycemia
 Kidney Diseases Antibodies  >1 publications with T1R3 and Kidney Diseases
 Dental Caries Antibodies  >1 publications with T1R3 and Dental Caries
 Carcinoma Antibodies  >1 publications with T1R3 and Carcinoma
 Infertility, Male Antibodies  >1 publications with T1R3 and Infertility, Male

Organs/Tissues associated with anti-T1R3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with T1R3 and Brain
 Liver Antibodies  >3 publications with T1R3 and Liver
 Testis Antibodies  >3 publications with T1R3 and Testis
 Pancreas Antibodies  >2 publications with T1R3 and Pancreas
 Intestine Antibodies  >2 publications with T1R3 and Intestine
 Muscle Antibodies  >2 publications with T1R3 and Muscle
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