SYT6 Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]

SYT6: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)- regulation of exocytosis in acrosomal reaction in sperm. Belongs to the synaptotagmin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: extrinsic to membrane; synaptic vesicle membrane; integral to membrane; plasma membrane; cytosol; cell junction

Molecular Function: clathrin binding; protein homodimerization activity; syntaxin binding; calcium-dependent phospholipid binding; protein heterodimerization activity; transporter activity; metal ion binding; calcium-dependent protein binding