Rabbit Anti-FPR2 Polyclonal Antibody – Cat# MBS244055

Anti-FPR2 / FPRL1 antibody IHC of human spleen, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 20-40 ug/ml.

FPR2 Antibody – Rabbit Polyclonal

Name: FPR2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS244055
Price: 650 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244055

FPRL1, a Chemoattractant Receptor also called Lipoxin A4 Receptor, functions as a component of the inflammatory response. Its stimulation results in neutrophil activation and desensitization of chemokine receptors in monocytes (Le et al., 2000). The receptor… More details

$650 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FPR2 / FPRL1, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human FPR2 / FPRL1

Product Gene Name

anti-FPR2 antibody

Product Synonym Gene Name

FPRL1

Product Synonym Names

Anti-FPR2 / FPRL1 Antibody (N-Terminus) IHC-plus; FPR2; ALXR; FMLP-R-I; FMLP-related receptor I; Fpr-rs1; FPRL1; FPR-like 1; Fprl-1; HM63; FMLP-R-II; FMLPX; Formyl peptide receptor-like 1; FPR2A; FPRH1; FPRH2; LXA4 receptor; LXA4R; Lipoxin A4 receptor; Lipoxin receptor; N-formyl peptide receptor 2; Human FPR2; FPRL1

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Chimpanzee, Gorilla, Human
Predicted Reactivity: Orangutan, Monkey (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human FPR2 / FPRL1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

38,964 Da

OMIM

136538

3D Structure

ModBase 3D Structure for P25090

Target Species

Human

Immunogen Description

Synthetic 18 amino acid peptide from N-terminal extracellular domain of human FPR2 / FPRL1. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Orangutan, Monkey (94%); Marmoset, Rabbit (83%).

Immunogen Type

Synthetic peptide

Immunogen

FPR2 / FPRL1 antibody was raised against synthetic 18 amino acid peptide from N-terminal extracellular domain of human FPR2 / FPRL1. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Orangutan, Monkey (94%); Marmoset, Rabbit (83%).

Antigen Modification

N-Terminus

Product Categories/Family for anti-FPR2 antibody

Family: GPCR; Subfamily: Chemoattractant

Applications Tested/Suitable for anti-FPR2 antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-FPR2 antibody

IHC-P (20 - 40 ug/ml)

Other Notes

Small volumes of anti-FPR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FPR2 purchase

MBS244055 is an antibody targeting FPR2. Also known as Rabbit Polyclonal to Human FPR2 / FPRL1. Reactive in Chimpanzee, Gorilla, Human
Predicted Reactivity: Orangutan, Monkey (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FPR2. It may not necessarily be applicable to this product.

NCBI GI #

4503781

NCBI GeneID

2358

NCBI Accession #

NP_001453.1

UniProt Primary Accession #

P25090

UniProt Secondary Accession #

A8K3E2

UniProt Related Accession #

P25090; AAB23104

GenBank Nucleotide #

NM_001462.3

NCBI Official Full Name

N-formyl peptide receptor 2

NCBI Official Synonym Full Names

formyl peptide receptor 2

NCBI Official Symbol

FPR2

NCBI Official Synonym Symbols

ALXR; HM63; FMLPX; FPR2A; FPRH1; FPRH2; FPRL1; LXA4R; FMLP-R-II

UniProt Protein Name

N-formyl peptide receptor 2

UniProt Synonym Protein Names

FMLP-related receptor I; FMLP-R-I; Formyl peptide receptor-like 1; HM63; Lipoxin A4 receptor; LXA4 receptor; RFP

Protein Family

Formyl peptide receptor

UniProt Gene Name

FPR2

UniProt Synonym Gene Names

FPRH1; FPRL1; LXA4R; FMLP-R-I; LXA4 receptor

UniProt Entry Name

FPR2_HUMAN

NCBI Protein Information

N-formyl peptide receptor 2; RFP; FMLP-R-I; LXA4 receptor; FMLP-related receptor I; formyl peptide receptor-like 1; lipoxin A4 receptor (formyl peptide receptor related)

UniProt Comments for FPR2

FPR2: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Motility/polarity/chemotaxis; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19q13.3-q13.4

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; N-formyl peptide receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; inflammatory response; cell motility; chemotaxis; cell adhesion

Research Articles on FPR2

1. Uteroglobin is a possible ligand of the lipoxin receptor and it may have a role in inhibiting serum amyloid A-driven inflammation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FPR2 antibody

Reference Product	PubMed Publications
FPR1 antibody	>74 publications with FPR2 and FPR1
ANXA1 antibody	>24 publications with FPR2 and ANXA1
CXCR2 antibody	>6 publications with FPR2 and CXCR2
CXCR1 antibody	>5 publications with FPR2 and CXCR1
CCR1 antibody	>3 publications with FPR2 and CCR1
PLAUR antibody	>3 publications with FPR2 and PLAUR
APP antibody	>2 publications with FPR2 and APP

Pathways associated with anti-FPR2 antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway antibodies	Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram

Diseases associated with anti-FPR2 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>193 publications with FPR2 and Inflammation
Necrosis Antibodies	>29 publications with FPR2 and Necrosis
Lung Diseases Antibodies	>26 publications with FPR2 and Lung Diseases
Vascular Diseases Antibodies	>17 publications with FPR2 and Vascular Diseases
Autoimmune Diseases Antibodies	>15 publications with FPR2 and Autoimmune Diseases
Lung Injury Antibodies	>9 publications with FPR2 and Lung Injury
Respiratory Hypersensitivity Antibodies	>8 publications with FPR2 and Respiratory Hypersensitivity
Fibrosis Antibodies	>8 publications with FPR2 and Fibrosis
Carcinoma Antibodies	>7 publications with FPR2 and Carcinoma
Respiratory Tract Infections Antibodies	>6 publications with FPR2 and Respiratory Tract Infections

Organs/Tissues associated with anti-FPR2 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>196 publications with FPR2 and Blood
Lung Antibodies	>48 publications with FPR2 and Lung
Kidney Antibodies	>13 publications with FPR2 and Kidney
Bone Marrow Antibodies	>12 publications with FPR2 and Bone Marrow
Spleen Antibodies	>8 publications with FPR2 and Spleen
Heart Antibodies	>6 publications with FPR2 and Heart
Connective Tissue Antibodies	>6 publications with FPR2 and Connective Tissue
Placenta Antibodies	>3 publications with FPR2 and Placenta
Testis Antibodies	>1 publications with FPR2 and Testis