• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

GCC2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244086

MBS244086 is an antibody targeting GCC2. Also known as Goat Polyclonal to Human GCC2. Reactive in Gibbon, HumanPredicted Reactivity: Gorilla, Monkey, Rat, Bat, Hamster, Horse, Rabbit (at least 90% immunogen sequence identity). Host: Goat. More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
GCC2, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human GCC2
Product Gene Name
anti-GCC2 antibody
Product Synonym Names
Anti-GCC2 Antibody (Internal) IHC-plus; GCC2; CLL-associated antigen KW-11; CTCL tumor antigen se1-1; GCC185; GCC protein; 185-kD; Ran-binding protein 2-like 4; RANBP2L4; REN53; KIAA0336; Human GCC2
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Human
Predicted Reactivity: Gorilla, Monkey, Rat, Bat, Hamster, Horse, Rabbit (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human GCC2. This antibody is expected to recognise both reported isoforms (NP_055450.1and NP_852118.1).
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
5,043 Da
OMIM
612711
3D Structure
ModBase 3D Structure for Q8IWJ2
Target Species
Human
Immunogen Description
Synthetic peptide C-QKLTNKNNKIED from an internal region of human GCC2 (NP_055450.1; NP_852118.1). Percent identity by BLAST analysis: Human, Gibbon (100%); Gorilla, Monkey, Marmoset, Rat, Hamster, Elephant, Bat, Horse, Rabbit (92%).
Immunogen Type
Synthetic peptide
Immunogen
GCC2 antibody was raised against synthetic peptide C-QKLTNKNNKIED from an internal region of human GCC2 (NP_055450.1; NP_852118.1). Percent identity by BLAST analysis: Human, Gibbon (100%); Gorilla, Monkey, Marmoset, Rat, Hamster, Elephant, Bat, Horse, Rabbit (92%); Mouse, Bovine, Pig (83%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-GCC2 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-GCC2 antibody
ELISA (1:16000), IHC-P (3.75 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:16000. Western Blot: Preliminary experiments gave an approx 60kD band in Human Lymph Node and Testis lysates after 0.03 ug/ml antibody staining. Please note that currently we cannot find an explanati...

Immunohistochemistry (IHC) of anti-GCC2 antibody

Anti-GCC2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-GCC2 Polyclonal Antibody – Cat# MBS244086

Immunohistochemistry (IHC) of anti-GCC2 antibody

Anti-GCC2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-GCC2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244086

Immunohistochemistry (IHC) of anti-GCC2 antibody

Anti-GCC2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-GCC2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244086

Other Notes

Small volumes of anti-GCC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GCC2. It may not necessarily be applicable to this product.

NCBI GI #
7662062
NCBI GeneID
9648
NCBI Accession #
NP_055450.1
UniProt Primary Accession #
Q8IWJ2
UniProt Secondary Accession #
O15045; Q4ZG46; Q8TDH3; Q9H2G8; A6H8X8
UniProt Related Accession #
Q8IWJ2
GenBank Nucleotide #
NM_014635.3
NCBI Official Synonym Full Names
GRIP and coiled-coil domain containing 2
NCBI Official Symbol
GCC2
NCBI Official Synonym Symbols
REN53; GCC185; RANBP2L4
UniProt Protein Name
GRIP and coiled-coil domain-containing protein 2
UniProt Synonym Protein Names
185 kDa Golgi coiled-coil protein; GCC185; CLL-associated antigen KW-11; CTCL tumor antigen se1-1; Ran-binding protein 2-like 4; RanBP2L4; Renal carcinoma antigen NY-REN-53
UniProt Gene Name
GCC2
UniProt Synonym Gene Names
KIAA0336; RANBP2L4; GCC185; RanBP2L4
UniProt Entry Name
GCC2_HUMAN
NCBI Protein Information
GRIP and coiled-coil domain-containing protein 2

NCBI Summary for GCC2

The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Show more

UniProt Comments for GCC2

GCC2: Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, peripheral

Chromosomal Location of Human Ortholog: 2q12.3

Cellular Component: nucleoplasm; Golgi apparatus; membrane; cytoplasm; trans-Golgi network; nucleus

Molecular Function: identical protein binding; protein binding

Biological Process: microtubule organizing center organization and biogenesis; protein targeting to lysosome; protein localization in Golgi apparatus; Golgi to plasma membrane protein transport; protein targeting to Golgi; retrograde transport, endosome to Golgi
Show more

Research Articles on GCC2

1. Deletion of the ARL4A-interacting region of GCC185 results in inability to maintain Golgi structure and modulate endosome-to-Golgi transport.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GCC2 antibody

 Reference Product  PubMed Publications
 ARL1 antibody  >5 publications with GCC2 and ARL1
 RAB6A antibody  >1 publications with GCC2 and RAB6A

Pathways associated with anti-GCC2 antibody

 Products by Pathway  Pathway Diagram
 Deregulation Of Rab And Rab Effector Genes In Bladder Cancer Pathway antibodies  Deregulation Of Rab And Rab Effector Genes In Bladder Cancer Pathway Diagram

Organs/Tissues associated with anti-GCC2 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with GCC2 and Eye
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000