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TRPC1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244146

MBS244146 is an antibody targeting TRPC1. Also known as Goat Polyclonal to Human TRPC1. Reactive in Gibbon, Bovine, Chicken, Dog, Gorilla, Horse, Human, Monkey, Mouse, Pig, Rabbit, RatPredicted Reactivity: Bat, Zebrafish (at least 90% immunogen sequence… More details

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Product Overview

Online Datasheet in PDF
Product Name
TRPC1, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human TRPC1
Product Gene Name
anti-TRPC1 antibody
Product Synonym Names
Anti-TRPC1 Antibody (Internal) IHC-plus; TRPC1; HTRP-1; TRP1; TRP-1; Trrp1; Transient receptor protein 1; Human TRPC1
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Bovine, Chicken, Dog, Gorilla, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Predicted Reactivity: Bat, Zebrafish (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human TRPC1.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
87,617 Da
OMIM
602343
3D Structure
ModBase 3D Structure for P48995
Target Species
Human
Immunogen Description
Synthetic peptide NLKQKRDENYQK from internal region of human TRPC1 (NP_003295.1).
Immunogen Type
Synthetic peptide
Immunogen
TRPC1 antibody was raised against synthetic peptide NLKQKRDENYQK from internal region of human TRPC1 (NP_003295.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Elephant, Panda, Dog, Bovine, Horse, Rabbit, Pig, Opossum, Turkey, Chicken, Platypus, Lizard, Pufferfish (100%); Bat, Trout, Seabass, Stickleback, Zebrafish (92%); Xenopus (83%).
Antigen Modification
Internal

Product Categories/Family for anti-TRPC1 antibody

Family: Ion Channel; Subfamily: Calcium channel - TRP
Applications Tested/Suitable for anti-TRPC1 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-TRPC1 antibody
IHC-P (3.75 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-TRPC1 antibody

Anti-TRPC1 antibody IHC of human prostate, fibromuscular stroma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-TRPC1 Polyclonal Antibody – Cat# MBS244146

Immunohistochemistry (IHC) of anti-TRPC1 antibody

Anti-TRPC1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-TRPC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244146

Other Notes

Small volumes of anti-TRPC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TRPC1. It may not necessarily be applicable to this product.

NCBI GI #
4507685
NCBI GeneID
7220
NCBI Accession #
NP_003295.1
UniProt Primary Accession #
P48995
UniProt Secondary Accession #
Q14CE4
UniProt Related Accession #
P48995
GenBank Nucleotide #
NM_003304.4
NCBI Official Full Name
short transient receptor potential channel 1 isoform 2
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily C, member 1
NCBI Official Symbol
TRPC1
NCBI Official Synonym Symbols
TRP1; HTRP-1
UniProt Protein Name
Short transient receptor potential channel 1
UniProt Synonym Protein Names
Transient receptor protein 1; TRP-1
Protein Family
Indole-3-glycerol phosphate synthase
UniProt Gene Name
TRPC1
UniProt Synonym Gene Names
TRP1; TrpC1; TRP-1
UniProt Entry Name
TRPC1_HUMAN
NCBI Protein Information
short transient receptor potential channel 1; TRP-1; transient receptor protein 1; transient receptor potential canonical 1; capacitative calcium channel protein Trp1

NCBI Summary for TRPC1

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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UniProt Comments for TRPC1

TRPC1: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium

Chromosomal Location of Human Ortholog: 3q23

Cellular Component: sarcomere; costamere; basolateral plasma membrane; integral to plasma membrane; plasma membrane; receptor complex; lipid raft

Molecular Function: store-operated calcium channel activity; protein binding; calcium channel activity; cation channel activity

Biological Process: axon guidance; cytosolic calcium ion homeostasis; calcium ion transport; positive regulation of release of sequestered calcium ion into cytosol; response to calcium ion; transmembrane transport; saliva secretion
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Research Articles on TRPC1

1. the reciprocal shift in transient receptor potential channel 1 (TRPC1) and stromal interaction molecule 2 (STIM2) contributes to Ca2+ remodeling and cancer hallmarks in colorectal carcinoma cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TRPC1 antibody

 Reference Product  PubMed Publications
 TRPC3 antibody  >200 publications with TRPC1 and TRPC3
 TRPC6 antibody  >197 publications with TRPC1 and TRPC6
 TRPC4 antibody  >169 publications with TRPC1 and TRPC4
 TRPC5 antibody  >126 publications with TRPC1 and TRPC5
 STIM1 antibody  >114 publications with TRPC1 and STIM1
 CAV1 antibody  >14 publications with TRPC1 and CAV1
 PKD2 antibody  >9 publications with TRPC1 and PKD2
 ITPR1 antibody  >5 publications with TRPC1 and ITPR1
 ITPR3 antibody  >2 publications with TRPC1 and ITPR3

Pathways associated with anti-TRPC1 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Netrin-1 Signaling Pathway antibodies  Netrin-1 Signaling Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram

Diseases associated with anti-TRPC1 antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >40 publications with TRPC1 and Hypertension
 Hypertrophy Antibodies  >31 publications with TRPC1 and Hypertrophy
 Heart Diseases Antibodies  >26 publications with TRPC1 and Heart Diseases
 Brain Diseases Antibodies  >19 publications with TRPC1 and Brain Diseases
 Necrosis Antibodies  >16 publications with TRPC1 and Necrosis
 Inflammation Antibodies  >15 publications with TRPC1 and Inflammation
 Kidney Diseases Antibodies  >15 publications with TRPC1 and Kidney Diseases
 Cardiomegaly Antibodies  >14 publications with TRPC1 and Cardiomegaly
 Pain Antibodies  >10 publications with TRPC1 and Pain
 Adenocarcinoma Antibodies  >9 publications with TRPC1 and Adenocarcinoma

Organs/Tissues associated with anti-TRPC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >96 publications with TRPC1 and Brain
 Kidney Antibodies  >64 publications with TRPC1 and Kidney
 Heart Antibodies  >62 publications with TRPC1 and Heart
 Lung Antibodies  >43 publications with TRPC1 and Lung
 Nerve Antibodies  >31 publications with TRPC1 and Nerve
 Bone Antibodies  >24 publications with TRPC1 and Bone
 Liver Antibodies  >16 publications with TRPC1 and Liver
 Embryonic Tissue Antibodies  >14 publications with TRPC1 and Embryonic Tissue
 Eye Antibodies  >13 publications with TRPC1 and Eye
 Prostate Antibodies  >10 publications with TRPC1 and Prostate
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