WNT2 Antibody – Rabbit Polyclonal

This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

WNT2: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Belongs to the Wnt family.

Protein type: Cell development/differentiation; Extracellular matrix; Cell adhesion; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q31.2

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; cytoplasm; extracellular region; plasma membrane

Molecular Function: protein binding; frizzled binding; cytokine activity; receptor agonist activity

Biological Process: lens development in camera-type eye; cell fate commitment; Wnt receptor signaling pathway; atrial cardiac muscle morphogenesis; Wnt receptor signaling pathway through beta-catenin; neuron differentiation; positive regulation of fibroblast proliferation; cell-cell signaling; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; lung development; positive regulation of cardiac muscle cell proliferation