Rabbit Anti-GPR68 Polyclonal Antibody – Cat# MBS244167

Anti-GPR68 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPR68 Antibody – Rabbit Polyclonal

Name: GPR68 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS244167
Price: 630 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244167

OGR1, a Lysophospholipid/Lysosphingolipid Receptor, was isolated by degenerate PCR from an ovarian cell line cDNA library. It is not expressed in normal ovary. OGR1 binds sphingosylphosporylcholine, a lipid molecule involved in cell growth and survival.… More details

$630 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GPR68 / OGR1, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human GPR68 / OGR1

Product Gene Name

anti-GPR68 antibody

Product Synonym Gene Name

OGR1

Product Synonym Names

Anti-GPR68 / OGR1 Antibody (Cytoplasmic Domain) IHC-plus; GPR68; Brgrb; G protein-coupled receptor 68; G-protein coupled receptor 68; OGR1; Brgr1; GPR12A; OGR-1; Human GPR68; OGR1

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Bat, Gibbon, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Predicted Reactivity: Bovine, Dog (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human GPR68. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

41,077 Da

OMIM

601404

3D Structure

ModBase 3D Structure for Q15743

Target Species

Human

Immunogen Description

Synthetic 18 amino acid peptide from 2nd cytoplasmic domain of human GPR68. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bat, Horse, Rabbit, Pig (100%).

Immunogen Type

Synthetic peptide

Immunogen

GPR68 / OGR1 antibody was raised against synthetic 18 amino acid peptide from 2nd cytoplasmic domain of human GPR68. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bat, Horse, Rabbit, Pig (100%); Dog, Bovine (94%); Chicken, Platypus (89%).

Antigen Modification

Cytoplasmic Domain

Product Categories/Family for anti-GPR68 antibody

Family: GPCR; Subfamily: Lysophospholipid/Lysosphingolipid

Applications Tested/Suitable for anti-GPR68 antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-GPR68 antibody

IHC-P (20 ug/ml)

Other Notes

Small volumes of anti-GPR68 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GPR68 purchase

MBS244167 is an antibody targeting GPR68. Also known as Rabbit Polyclonal to Human GPR68 / OGR1. Reactive in Bat, Gibbon, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Predicted Reactivity: Bovine, Dog (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GPR68. It may not necessarily be applicable to this product.

NCBI GI #

295054323

NCBI GeneID

8111

NCBI Accession #

NP_003476.3

UniProt Primary Accession #

Q15743

UniProt Secondary Accession #

Q13334; Q4VBB4; Q6IX34

UniProt Related Accession #

Q15743

GenBank Nucleotide #

NM_003485.3

NCBI Official Full Name

ovarian cancer G-protein coupled receptor 1

NCBI Official Synonym Full Names

G protein-coupled receptor 68

NCBI Official Symbol

GPR68

NCBI Official Synonym Symbols

OGR1; GPR12A

UniProt Protein Name

Ovarian cancer G-protein coupled receptor 1

UniProt Synonym Protein Names

G-protein coupled receptor 68; GPR12A; Sphingosylphosphorylcholine receptor

Protein Family

Ovarian cancer G-protein coupled receptor

UniProt Gene Name

GPR68

UniProt Synonym Gene Names

OGR1; OGR-1

UniProt Entry Name

OGR1_HUMAN

NCBI Protein Information

ovarian cancer G-protein coupled receptor 1; G-protein coupled receptor 68; sphingosylphosphorylcholine receptor; ovarian cancer G protein-coupled receptor, 1

UniProt Comments for GPR68

GPR68: Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Tumor suppressor; Receptor, GPCR

Chromosomal Location of Human Ortholog: 14q31

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of monocyte differentiation; inflammatory response

Research Articles on GPR68

1. Provide evidence for the roles of OGR1 and ASIC1a in the regulation of intestinal passive Mg(2+) absorption.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GPR68 antibody

Reference Product	PubMed Publications
GPR4 antibody	>21 publications with GPR68 and GPR4
GPR132 antibody	>2 publications with GPR68 and GPR132
RGS18 antibody	>1 publications with GPR68 and RGS18

Pathways associated with anti-GPR68 antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies	Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Osteoclast Signaling Pathway antibodies	Osteoclast Signaling Pathway Diagram

Diseases associated with anti-GPR68 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>12 publications with GPR68 and Inflammation
Heart Diseases Antibodies	>1 publications with GPR68 and Heart Diseases
Liver Neoplasms Antibodies	>1 publications with GPR68 and Liver Neoplasms
Necrosis Antibodies	>1 publications with GPR68 and Necrosis

Organs/Tissues associated with anti-GPR68 antibody

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>12 publications with GPR68 and Bone
Blood Antibodies	>10 publications with GPR68 and Blood
Lung Antibodies	>7 publications with GPR68 and Lung
Connective Tissue Antibodies	>5 publications with GPR68 and Connective Tissue
Prostate Antibodies	>5 publications with GPR68 and Prostate
Intestine Antibodies	>3 publications with GPR68 and Intestine
Pancreas Antibodies	>3 publications with GPR68 and Pancreas
Brain Antibodies	>2 publications with GPR68 and Brain
Thymus Antibodies	>1 publications with GPR68 and Thymus
Placenta Antibodies	>1 publications with GPR68 and Placenta