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PDLIM1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244184

MBS244184 is an antibody targeting PDLIM1. Also known as Rabbit Polyclonal (IgG) to Human PDLIM1. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PDLIM1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human PDLIM1
Product Gene Name
anti-PDLIM1 antibody
Product Synonym Names
Anti-PDLIM1 Antibody (aa61-110) IHC-plus; PDLIM1; CLP-36; CLP36; CLIM1; Elfin; ENIGMA; HCLIM1; PDZ and LIM domain 1; Lim; PDZ and LIM domain 1 (elfin); PDZ and LIM domain protein 1; LIM domain protein CLP-36; Human PDLIM1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
PDLIM1 Antibody detects endogenous levels of total PDLIM1 protein.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
36,072 Da
OMIM
605900
3D Structure
ModBase 3D Structure for O00151
Target Species
Human
Immunogen Description
Synthetic peptide from human PDLIM1 (aa61-110).
Immunogen
PDLIM1 antibody was raised against synthetic peptide from human PDLIM1 (aa61-110).
Antigen Modification
aa61-110
Applications Tested/Suitable for anti-PDLIM1 antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-PDLIM1 antibody
ELISA (1:5000), IF (1:100 - 1:500), IHC-P (15 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-PDLIM1 antibody

Anti-PDLIM1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 15 ug/ml.
Rabbit Anti-PDLIM1 Polyclonal Antibody – Cat# MBS244184

Immunofluorescence (IF) of anti-PDLIM1 antibody

Immunofluorescence of HepG2 cells, using PDLIM1 Antibody. The picture on the right is treated with the synthesized peptide.
Rabbit Anti-PDLIM1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS244184

Western Blot (WB) of anti-PDLIM1 antibody

Western blot of extracts from Jurkat/COLO205/293/HepG2/HUVEC cells, using PDLIM1 Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-PDLIM1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS244184

Other Notes

Small volumes of anti-PDLIM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PDLIM1. It may not necessarily be applicable to this product.

NCBI GI #
13994151
NCBI GeneID
9124
NCBI Accession #
NP_066272.1
UniProt Primary Accession #
O00151
UniProt Secondary Accession #
Q5VZH5; Q9BPZ9; B2RBS6
UniProt Related Accession #
O00151
GenBank Nucleotide #
NM_020992.3
NCBI Official Full Name
PDZ and LIM domain protein 1
NCBI Official Synonym Full Names
PDZ and LIM domain 1
NCBI Official Symbol
PDLIM1
NCBI Official Synonym Symbols
CLIM1; CLP36; CLP-36; hCLIM1; HEL-S-112
UniProt Protein Name
PDZ and LIM domain protein 1
UniProt Synonym Protein Names
C-terminal LIM domain protein 1; Elfin; LIM domain protein CLP-36
Protein Family
PDZ and LIM domain protein
UniProt Gene Name
PDLIM1
UniProt Synonym Gene Names
CLIM1; CLP36
UniProt Entry Name
PDLI1_HUMAN
NCBI Protein Information
PDZ and LIM domain protein 1; elfin; LIM domain protein CLP-36; epididymis secretory protein Li 112; carboxyl terminal LIM domain protein 1

NCBI Summary for PDLIM1

This gene encodes a member of the enigma protein family. The protein contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. It is a cytoplasmic protein associated with the cytoskeleton. The protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14 and 17. [provided by RefSeq, Oct 2012]
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UniProt Comments for PDLIM1

CLIM1: a cytoskeletal adaptor protein that bring other proteins to the cytoskeleton. Interacts with alpha-actinins 1, 2 and 4. Recruits the Clik1 kinase to actin stress fibers in nonmuscle cells. Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 10q23.1

Cellular Component: transcription factor complex; cytoskeleton; focal adhesion; cytoplasm

Molecular Function: zinc ion binding; transcription coactivator activity

Biological Process: regulation of transcription, DNA-dependent; response to hypoxia; response to oxidative stress
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Research Articles on PDLIM1

1. Femtomolar Zn2+ affinity of LIM domain of PDLIM1 protein uncovers crucial contribution of protein-protein interactions to protein stability.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PDLIM1 antibody

 Reference Product  PubMed Publications
 ACTN4 antibody  >2 publications with PDLIM1 and ACTN4
 STK35 antibody  >2 publications with PDLIM1 and STK35
 ACTN1 antibody  >1 publications with PDLIM1 and ACTN1

Diseases associated with anti-PDLIM1 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >1 publications with PDLIM1 and Disease Models, Animal
 Carcinoma Antibodies  >1 publications with PDLIM1 and Carcinoma
 Adenocarcinoma Antibodies  >1 publications with PDLIM1 and Adenocarcinoma
 Inflammation Antibodies  >1 publications with PDLIM1 and Inflammation

Organs/Tissues associated with anti-PDLIM1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >8 publications with PDLIM1 and Muscle
 Nerve Antibodies  >5 publications with PDLIM1 and Nerve
 Kidney Antibodies  >2 publications with PDLIM1 and Kidney
 Testis Antibodies  >2 publications with PDLIM1 and Testis
 Brain Antibodies  >2 publications with PDLIM1 and Brain
 Liver Antibodies  >2 publications with PDLIM1 and Liver
 Ganglia Antibodies  >2 publications with PDLIM1 and Ganglia
 Heart Antibodies  >2 publications with PDLIM1 and Heart
 Spleen Antibodies  >2 publications with PDLIM1 and Spleen
 Placenta Antibodies  >2 publications with PDLIM1 and Placenta
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