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ZMYM2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244193

MBS244193 is an antibody targeting ZMYM2. Also known as Rabbit Polyclonal to Human ZMYM2 / RAMP. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
ZMYM2 / RAMP, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human ZMYM2 / RAMP
Product Gene Name
Product Synonym Gene Name
RAMP
Product Synonym Names
Anti-ZMYM2 / RAMP Antibody (C-Terminus) IHC-plus; ZMYM2; FIM; SCLL; MYM; Zinc finger MYM-type protein 2; Zinc finger protein 198; ZNF198; Zinc finger; MYM-type 2; RAMP; Human ZMYM2; RAMP
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human ZMYM2. At least two isoforms of ZMYM1 are known to exist; this antibody will detect only the shorter isoform. ZMYM1 antibody is predicted to not cross-react with other ZMYM protein family members.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
50,809 Da
OMIM
602221
3D Structure
ModBase 3D Structure for Q9UBW7
Target Species
Human
Immunogen Description
A 17 amino acid peptide near the carboxy terminus of human ZMYM1
Immunogen Type
Synthetic peptide
Immunogen
ZMYM2 / RAMP antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ZMYM1
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-ZMYM2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-ZMYM2 antibody
IHC-P (5 ug/ml), WB (1 - 2 ug/ml)

Immunohistochemistry (IHC) of anti-ZMYM2 antibody

Anti-ZMYM2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-ZMYM2 Polyclonal Antibody – Cat# MBS244193

Immunofluorescence (IF) of anti-ZMYM2 antibody

Immunofluorescence of ZMYM2 in HeLa cells with ZMYM2 antibody at 20 ug/ml.
Rabbit Anti-ZMYM2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS244193

Immunocytochemistry (ICC) of anti-ZMYM2 antibody

Immunocytochemistry of ZMYM2 in HeLa cells with ZMYM2 antibody at 10 ug/ml.
Rabbit Anti-ZMYM2 Polyclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS244193

Western Blot (WB) of anti-ZMYM2 antibody

Western blot analysis of ZMYM2 in EL4 cell lysate with ZMYM2 antibody at (A) 0.125 and (B) 0.25 ug/ml.
Rabbit Anti-ZMYM2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS244193

Other Notes

Small volumes of anti-ZMYM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ZMYM2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
zinc finger MYM-type protein 2
NCBI Official Synonym Full Names
zinc finger, MYM-type 2
NCBI Official Symbol
ZMYM2
NCBI Official Synonym Symbols
FIM; MYM; RAMP; SCLL; ZNF198
UniProt Protein Name
Zinc finger MYM-type protein 2
UniProt Synonym Protein Names
Fused in myeloproliferative disorders protein; Rearranged in atypical myeloproliferative disorder protein; Zinc finger protein 198
UniProt Gene Name
ZMYM2
UniProt Synonym Gene Names
FIM; RAMP; ZNF198
UniProt Entry Name
ZMYM2_HUMAN
NCBI Protein Information
zinc finger MYM-type protein 2; zinc finger protein 198; fused in myeloproliferative disorders protein; rearranged in an atypical myeloproliferative disorder

NCBI Summary for ZMYM2

The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
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UniProt Comments for ZMYM2

ZNF198: a probable transcriptional regulator of the krueppel C2H2-type zinc-finger protein family. The translocation between FGFR and ZNF198 (8;13)(p11;q12) is oncogenic, causing stem cell leukemia lymphoma syndrome (SCLL), a myeloproliferative disorder (MPD) that evolves to acute myeloid leukemia and/or lymphoma. The transforming activity of ZNF198-FGFR1 requires the proline-rich domains, but not the ZNF domains, of ZNF198.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 13q11-q12

Cellular Component: PML body; cytosol

Molecular Function: zinc ion binding; ubiquitin conjugating enzyme binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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