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MC4R Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244242

Melanocortin 4 receptor (MC4R), a Melanocortin Receptor, has been shown to affect food intake and energy balance. Recently MC4R has been shown to modulate erectile function and sexual behavior (Van Der Ploeg et al. 2002). More details

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Product Overview

Online Datasheet in PDF
Product Name
MC4R / Melanocortin 4 Receptor, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human MC4R / Melanocortin 4 Receptor
Product Gene Name
anti-MC4R antibody
Product Synonym Names
Anti-MC4R / Melanocortin 4 Receptor Antibody (Cytoplasmic Domain) IHC-plus; MC4R; Melanocortin receptor 4; MC4-R; MC4; MC4 receptor; Melanocortin 4 receptor; Human MC4R; Melanocortin 4 Receptor
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Chimpanzee, Gorilla, Human, Monkey, Orangutan, Rabbit, Sheep
Predicted Reactivity: Rat, Bat, Dog, Guinea pig, Hamster, Horse, Pig (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human MC4 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
36,943 Da
OMIM
gene 601665
3D Structure
ModBase 3D Structure for P32245
Target Species
Human
Immunogen Description
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human MC4 Receptor. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Marmoset, Tamarin, Sheep, Rabbit (100%).
Immunogen Type
Synthetic peptide
Immunogen
MC4R / Melanocortin 4 Receptor antibody was raised against synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human MC4 Receptor. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Marmoset, Tamarin, Sheep, Rabbit (100%); Rat, Bat, Dog, Hamster, Elephant, Panda, Horse, Pig, Opossum, Guinea pig (94%); Mouse, Bovine, Zebu, Chicken (88%); Platypus (81%).
Antigen Modification
Cytoplasmic Domain

Product Categories/Family for anti-MC4R antibody

Family: GPCR; Subfamily: Melanocortin
Applications Tested/Suitable for anti-MC4R antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-MC4R antibody
IHC-P (2.5 - 5 ug/ml)

Immunohistochemistry (IHC) of anti-MC4R antibody

Human, Kidney: Formalin-Fixed Paraffin-Embedded (FFPE)
Rabbit Anti-MC4R Polyclonal Antibody – Cat# MBS244242

Immunohistochemistry (IHC) of anti-MC4R antibody

Anti-MC4R / Melanocortin 4 Receptor antibody IHC of human brain neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-MC4R Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244242

Other Notes

Small volumes of anti-MC4R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MC4R purchase

MBS244242 is an antibody targeting MC4R. Also known as Rabbit Polyclonal to Human MC4R / Melanocortin 4 Receptor. Reactive in Gibbon, Chimpanzee, Gorilla, Human, Monkey, Orangutan, Rabbit, Sheep
Predicted Reactivity: Rat, Bat, Dog, Guinea pig, Hamster, Horse, Pig (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MC4R. It may not necessarily be applicable to this product.

NCBI GI #
119508433
NCBI GeneID
4160
NCBI Accession #
NP_005903.2
UniProt Primary Accession #
P32245
UniProt Secondary Accession #
Q16317; Q3MIJ6; B2RAC3
UniProt Related Accession #
P32245
GenBank Nucleotide #
NM_005912.2
NCBI Official Full Name
melanocortin receptor 4
NCBI Official Synonym Full Names
melanocortin 4 receptor
NCBI Official Symbol
MC4R
UniProt Protein Name
Melanocortin receptor 4
Protein Family
Melanocortin receptor
UniProt Gene Name
MC4R
UniProt Synonym Gene Names
MC4-R
UniProt Entry Name
MC4R_HUMAN
NCBI Protein Information
melanocortin receptor 4; MC4-R

NCBI Summary for MC4R

The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]
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UniProt Comments for MC4R

MC4R: receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. A G-protein coupled receptor that stimulates adenylate cyclase. Defects are a cause of autosomal dominant obesity

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q22

Cellular Component: integral to membrane; plasma membrane; nucleus

Molecular Function: neuropeptide binding; protein binding; melanocortin receptor activity; ubiquitin protein ligase binding; melanocyte stimulating hormone receptor activity; peptide hormone binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; diet induced thermogenesis; insulin secretion; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; positive regulation of bone resorption; feeding behavior; response to insulin stimulus

Disease: Obesity
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Research Articles on MC4R

1. Novel variants discovered in the MC4R and LEPR genes among severely obese children from the Iberian population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MC4R antibody

 Reference Product  PubMed Publications
 POMC antibody  >346 publications with MC4R and POMC
 AGRP antibody  >130 publications with MC4R and AGRP
 MC1R antibody  >75 publications with MC4R and MC1R
 LEP antibody  >24 publications with MC4R and LEP
 CRH antibody  >12 publications with MC4R and CRH
 GLP1R antibody  >3 publications with MC4R and GLP1R
 GHRH antibody  >1 publications with MC4R and GHRH

Pathways associated with anti-MC4R antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-MC4R antibody

 Disease Name  Pubmed Publications
 Obesity Antibodies  >620 publications with MC4R and Obesity
 Body Weight Antibodies  >563 publications with MC4R and Body Weight
 Weight Gain Antibodies  >94 publications with MC4R and Weight Gain
 Weight Loss Antibodies  >82 publications with MC4R and Weight Loss
 Hyperphagia Antibodies  >70 publications with MC4R and Hyperphagia
 Insulin Resistance Antibodies  >55 publications with MC4R and Insulin Resistance
 Hyperinsulinism Antibodies  >45 publications with MC4R and Hyperinsulinism
 Cardiovascular Diseases Antibodies  >37 publications with MC4R and Cardiovascular Diseases
 Hypertension Antibodies  >37 publications with MC4R and Hypertension
 Inflammation Antibodies  >34 publications with MC4R and Inflammation

Organs/Tissues associated with anti-MC4R antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >295 publications with MC4R and Brain
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