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IGFBP5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244271

MBS244271 is an antibody targeting IGFBP5. Also known as Rabbit Polyclonal (IgG) to Human IGFBP5. Reactive in Bat, Gibbon, Bovine, Dog, Gorilla, Goat, Hamster, Horse, Human, Monkey, Pig, RabbitPredicted Reactivity: Mouse, Rat, Chicken (at least 90% immunogen… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IGFBP5, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human IGFBP5
Product Gene Name
anti-IGFBP5 antibody
Product Synonym Names
Anti-IGFBP5 Antibody IHC-plus; IGFBP5; IBP-5; IGFBP-5; IBP5; IGF-binding protein 5; Human IGFBP5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Bat, Gibbon, Bovine, Dog, Gorilla, Goat, Hamster, Horse, Human, Monkey, Pig, Rabbit
Predicted Reactivity: Mouse, Rat, Chicken (at least 90% immunogen sequence identity)
Form/Format
TBS pH 7.4, containing 50% glycerol, 0.5 mg/ml BSA, and 0.02% sodium azide
Purity/Purification
Affinity Purified
Concentration
0.4 mg/ml (lot specific)
Specificity
The recognized sequence partially overlaps the IGFBP5 region identified as a nuclear localized signal.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
30,570 Da
OMIM
146734
3D Structure
ModBase 3D Structure for P24593
Target Species
Human
Immunogen Description
Human IGFBP5 amino acids 192-206 (CRRHMEASLQELKAS). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Dog, Bat, Bovine, Goat, Hamster, Elephant, Panda, Horse, Rabbit, Pig (100%); Mouse, Rat, Opossum, Chicken (93%); Marmoset (87%).
Immunogen
IGFBP5 antibody was raised against human IGFBP5 amino acids 192-206 (CRRHMEASLQELKAS). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Dog, Bat, Bovine, Goat, Hamster, Elephant, Panda, Horse, Rabbit, Pig (100%); Mouse, Rat, Opossum, Chicken (93%); Marmoset (87%).
Applications Tested/Suitable for anti-IGFBP5 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-IGFBP5 antibody
IHC-P (5 ug/ml), WB (1:200)

Immunohistochemistry (IHC) of anti-IGFBP5 antibody

Anti-IGFBP5 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-IGFBP5 Polyclonal Antibody – Cat# MBS244271

Western Blot (WB) of anti-IGFBP5 antibody

Western blot of IGFBP-5 antibody.
Rabbit Anti-IGFBP5 Polyclonal Antibody, Western Blot (WB) – Cat# MBS244271

Other Notes

Small volumes of anti-IGFBP5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IGFBP5. It may not necessarily be applicable to this product.

NCBI GI #
10834982
NCBI GeneID
3488
NCBI Accession #
NP_000590.1
UniProt Primary Accession #
P24593
UniProt Secondary Accession #
Q5U0A3
UniProt Related Accession #
P24593
GenBank Nucleotide #
NM_000599.3
NCBI Official Full Name
insulin-like growth factor-binding protein 5
NCBI Official Synonym Full Names
insulin-like growth factor binding protein 5
NCBI Official Symbol
IGFBP5
NCBI Official Synonym Symbols
IBP5
UniProt Protein Name
Insulin-like growth factor-binding protein 5
Protein Family
Insulin-like growth factor-binding protein
UniProt Gene Name
IGFBP5
UniProt Synonym Gene Names
IBP5; IBP-5; IGF-binding protein 5; IGFBP-5
UniProt Entry Name
IBP5_HUMAN
NCBI Protein Information
insulin-like growth factor-binding protein 5; IBP-5; IGFBP-5; IGF-binding protein 5

UniProt Comments for IGFBP5

IGFBP5: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Protein type: Cell cycle regulation; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: insulin-like growth factor binding protein complex; extracellular space; extracellular region

Molecular Function: protein binding; insulin-like growth factor I binding; fibronectin binding; insulin-like growth factor II binding

Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; mammary gland involution; hair follicle morphogenesis; negative regulation of smooth muscle cell proliferation; negative regulation of insulin-like growth factor receptor signaling pathway; glucose metabolic process; negative regulation of smooth muscle cell migration; signal transduction; glucose homeostasis; osteoblast differentiation; positive regulation of protein kinase B signaling cascade; cellular protein metabolic process; negative regulation of translation; striated muscle cell differentiation; negative regulation of osteoblast differentiation; regulation of cell growth; skeletal muscle growth; negative regulation of cell migration
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Research Articles on IGFBP5

1. IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5. IGFBP-5 and DOK5 are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IGFBP5 antibody

 Reference Product  PubMed Publications
 IGF1 antibody  >29 publications with IGFBP5 and IGF1
 PTH antibody  >20 publications with IGFBP5 and PTH
 IGF2 antibody  >17 publications with IGFBP5 and IGF2
 SERPINE1 antibody  >7 publications with IGFBP5 and SERPINE1
 THBS1 antibody  >4 publications with IGFBP5 and THBS1
 FHL2 antibody  >4 publications with IGFBP5 and FHL2
 PAPPA antibody  >3 publications with IGFBP5 and PAPPA
 FN1 antibody  >3 publications with IGFBP5 and FN1

Pathways associated with anti-IGFBP5 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram

Diseases associated with anti-IGFBP5 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >50 publications with IGFBP5 and Carcinoma
 Breast Neoplasms Antibodies  >50 publications with IGFBP5 and Breast Neoplasms
 Nervous System Diseases Antibodies  >36 publications with IGFBP5 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >23 publications with IGFBP5 and Cardiovascular Diseases
 Inflammation Antibodies  >22 publications with IGFBP5 and Inflammation
 Necrosis Antibodies  >22 publications with IGFBP5 and Necrosis
 Brain Diseases Antibodies  >21 publications with IGFBP5 and Brain Diseases
 Atrophy Antibodies  >20 publications with IGFBP5 and Atrophy
 Prostatic Neoplasms Antibodies  >20 publications with IGFBP5 and Prostatic Neoplasms
 Neoplasms, Experimental Antibodies  >19 publications with IGFBP5 and Neoplasms, Experimental

Organs/Tissues associated with anti-IGFBP5 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >148 publications with IGFBP5 and Muscle
 Bone Antibodies  >127 publications with IGFBP5 and Bone
 Ovary Antibodies  >68 publications with IGFBP5 and Ovary
 Vascular Antibodies  >54 publications with IGFBP5 and Vascular
 Connective Tissue Antibodies  >54 publications with IGFBP5 and Connective Tissue
 Liver Antibodies  >53 publications with IGFBP5 and Liver
 Brain Antibodies  >50 publications with IGFBP5 and Brain
 Mammary Gland Antibodies  >46 publications with IGFBP5 and Mammary Gland
 Embryonic Tissue Antibodies  >42 publications with IGFBP5 and Embryonic Tissue
 Kidney Antibodies  >41 publications with IGFBP5 and Kidney
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