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SLC5A1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244290

Solute Carrier Family 5 Member 1 (Slc5a1/SGLT1) is a member of the sodium dependent glucose transporters also known as co transporters or symporters. It is an integral membrane protein involved in the active transport of glucose and galactose across the… More details

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Product Overview

Online Datasheet in PDF
Product Name
SLC5A1 / SGLT1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human SLC5A1 / SGLT1
Product Gene Name
anti-SLC5A1 antibody
Product Synonym Gene Name
SGLT1
Product Synonym Names
Anti-SLC5A1 / SGLT1 Antibody (Internal) IHC-plus; SLC5A1; D22S675; HSGLT1; Na(+)/glucose cotransporter 1; Na+/glucose cotransporter 1; SGLT1; NAGT; Sodium-glucose transporter 1; Sodium/glucose cotransporter 1; Human SLC5A1; SGLT1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Orangutan
Predicted Reactivity: Chimpanzee, Gibbon (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human SLC5A1 / SGLT1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
60,097 Da
OMIM
gene 606824
3D Structure
ModBase 3D Structure for P13866
Target Species
Human
Immunogen Description
Synthetic 17 amino acid peptide from internal region of human SLC5A1 / SGLT1. Percent identity with other species by BLAST analysis: Human, Orangutan (100%); Chimpanzee, Gibbon (94%); Monkey (82%).
Immunogen Type
Synthetic peptide
Immunogen
SLC5A1 / SGLT1 antibody was raised against synthetic 17 amino acid peptide from internal region of human SLC5A1 / SGLT1. Percent identity with other species by BLAST analysis: Human, Orangutan (100%); Chimpanzee, Gibbon (94%); Monkey (82%).
Antigen Modification
Internal

Product Categories/Family for anti-SLC5A1 antibody

Family: Transporter; Subfamily: Solute:sodium symporter
Applications Tested/Suitable for anti-SLC5A1 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-SLC5A1 antibody
IHC-P (5 - 10 ug/ml)

Immunohistochemistry (IHC) of anti-SLC5A1 antibody

Anti-SLC5A1 / SGLT1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-SLC5A1 Polyclonal Antibody – Cat# MBS244290

Immunohistochemistry (IHC) of anti-SLC5A1 antibody

Anti-SLC5A1 / SGLT1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-SLC5A1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244290

Other Notes

Small volumes of anti-SLC5A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC5A1 purchase

MBS244290 is an antibody targeting SLC5A1. Also known as Rabbit Polyclonal to Human SLC5A1 / SGLT1. Reactive in Human, Orangutan
Predicted Reactivity: Chimpanzee, Gibbon (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC5A1. It may not necessarily be applicable to this product.

NCBI GI #
4507031
NCBI GeneID
6523
NCBI Accession #
NP_000334.1
UniProt Primary Accession #
P13866
UniProt Secondary Accession #
B2R7E2; B7Z4Q9; B7ZA69
UniProt Related Accession #
P13866
GenBank Nucleotide #
NM_000343.3
NCBI Official Full Name
sodium/glucose cotransporter 1 isoform 1
NCBI Official Synonym Full Names
solute carrier family 5 (sodium/glucose cotransporter), member 1
NCBI Official Symbol
SLC5A1
NCBI Official Synonym Symbols
NAGT; SGLT1; D22S675
UniProt Protein Name
Sodium/glucose cotransporter 1
UniProt Synonym Protein Names
High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1
Protein Family
Sodium/glucose cotransporter
UniProt Gene Name
SLC5A1
UniProt Synonym Gene Names
NAGT; SGLT1; Na(+)/glucose cotransporter 1
UniProt Entry Name
SC5A1_HUMAN
NCBI Protein Information
sodium/glucose cotransporter 1; Na+/glucose cotransporter 1; high affinity sodium-glucose cotransporter

NCBI Summary for SLC5A1

This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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UniProt Comments for SLC5A1

SLC5A1: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Expressed mainly in intestine and kidney. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 22q12.3

Cellular Component: integral to plasma membrane; brush border membrane; apical plasma membrane; plasma membrane; intercellular junction

Molecular Function: protein binding; glucose:sodium symporter activity

Biological Process: hexose transport; sodium ion transport; carbohydrate metabolic process; pathogenesis; glucose transport; transmembrane transport; metanephros development; intestinal absorption

Disease: Glucose/galactose Malabsorption
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Research Articles on SLC5A1

1. SGLT1 mRNA and GLUT2 mRNA expression are reduced significantly in CACo-2 cells exposed to berry extracts.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC5A1 antibody

 Reference Product  PubMed Publications
 SLC2A2 antibody  >44 publications with SLC5A1 and SLC2A2
 EGFR antibody  >9 publications with SLC5A1 and EGFR
 DPP4 antibody  >1 publications with SLC5A1 and DPP4
 GPR120 antibody  >1 publications with SLC5A1 and GPR120

Pathways associated with anti-SLC5A1 antibody

 Products by Pathway  Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram
 Hexose Transport Pathway antibodies  Hexose Transport Pathway Diagram
 Inositol Transporters Pathway antibodies  Inositol Transporters Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram

Diseases associated with anti-SLC5A1 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >39 publications with SLC5A1 and Disease Models, Animal
 Hyperglycemia Antibodies  >26 publications with SLC5A1 and Hyperglycemia
 Glucose-Galactose Malabsorption Antibodies  >23 publications with SLC5A1 and Glucose-Galactose Malabsorption
 Weight Gain Antibodies  >14 publications with SLC5A1 and Weight Gain
 Cardiovascular Diseases Antibodies  >11 publications with SLC5A1 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >11 publications with SLC5A1 and Kidney Diseases
 Inflammation Antibodies  >11 publications with SLC5A1 and Inflammation
 Hypertension Antibodies  >9 publications with SLC5A1 and Hypertension
 Insulin Resistance Antibodies  >8 publications with SLC5A1 and Insulin Resistance
 Death Antibodies  >8 publications with SLC5A1 and Death

Organs/Tissues associated with anti-SLC5A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >240 publications with SLC5A1 and Intestine
 Kidney Antibodies  >79 publications with SLC5A1 and Kidney
 Liver Antibodies  >48 publications with SLC5A1 and Liver
 Muscle Antibodies  >16 publications with SLC5A1 and Muscle
 Mouth Antibodies  >10 publications with SLC5A1 and Mouth
 Heart Antibodies  >10 publications with SLC5A1 and Heart
 Lung Antibodies  >6 publications with SLC5A1 and Lung
 Embryonic Tissue Antibodies  >4 publications with SLC5A1 and Embryonic Tissue
 Mammary Gland Antibodies  >2 publications with SLC5A1 and Mammary Gland
 Prostate Antibodies  >1 publications with SLC5A1 and Prostate
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