FZD5 Antibody – Rabbit Polyclonal

FZD5: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. Interacts with GOPC. Belongs to the G-protein coupled receptor Fz/Smo family.

Protein type: Membrane protein, multi-pass; GPCR, Fz/Smo family; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q33.3

Cellular Component: Golgi membrane; cell surface; tight junction; perinuclear region of cytoplasm; early endosome membrane; integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; protein binding; Wnt receptor activity; ubiquitin protein ligase binding; protein kinase binding

Biological Process: positive regulation of JNK activity; post-embryonic camera-type eye development; cell maturation; embryonic axis specification; T cell differentiation in the thymus; Wnt receptor signaling pathway through beta-catenin; embryonic camera-type eye development; neuron differentiation; G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; positive regulation of interferon-gamma production; determination of anterior/posterior axis, embryo; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; Spemann organizer formation