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ENPEP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244344

Human aminopeptidase A is a cell surface differentiation-related glycoprotein of 160 kD expressed by epithelial cells of the glomerulus and proximal tubules of the human kidney and in the majority of renal cell carcinomas. Expression of aminopeptidase A by… More details

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Product Overview

Product Name
ENPEP / Aminopeptidase A, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human ENPEP / Aminopeptidase A
Product Gene Name
anti-ENPEP antibody
Product Synonym Names
Anti-ENPEP / Aminopeptidase A Antibody IHC-plus; ENPEP; APA; Aminopeptidase A; AP-A; CD249 antigen; Differentiation antigen gp160; EAP; Glutamyl aminopeptidase; gp160; CD249; Human ENPEP; Aminopeptidase A
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
0.1 M Tris-glycine, pH 7, 10% Glycerol, 0.01% Thimerosal
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human Glutamyl aminopeptidase. Predicted cross-reactivity based on amino acid sequence homology: mouse (85%), rat (86%), bovine (89%), pig (90%).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
109,244 Da
OMIM
138297
3D Structure
ModBase 3D Structure for Q07075
Target Species
Human
Immunogen Description
Recombinant protein fragment containing a sequence corresponding to a region within amino acids 689 and 932 of Human ENPEP.
Immunogen Type
Recombinant protein
Immunogen
ENPEP / Aminopeptidase A antibody was raised against recombinant protein fragment containing a sequence corresponding to a region within amino acids 689 and 932 of Human ENPEP.

Product Categories/Family for anti-ENPEP antibody

Family: Exopeptidase; Subfamily: Metallopeptidase M1
Applications Tested/Suitable for anti-ENPEP antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-ENPEP antibody
IHC-P (10 ug/ml), WB (1:500 - 1:3000)

Immunohistochemistry (IHC) of anti-ENPEP antibody

Anti-ENPEP antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-ENPEP Polyclonal Antibody – Cat# MBS244344

Immunohistochemistry (IHC) of anti-ENPEP antibody

Anti-ENPEP antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-ENPEP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244344

Western Blot (WB) of anti-ENPEP antibody

Sample(30 ug whole cell lysate). A: Hep G2. B: HeLa S3. 7.5% SDS PAGE. ENPEP antibody diluted at 1:1000.
Rabbit Anti-ENPEP Polyclonal Antibody, Western Blot (WB) – Cat# MBS244344

Other Notes

Small volumes of anti-ENPEP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ENPEP purchase

MBS244344 is an antibody targeting ENPEP. Also known as Rabbit Polyclonal to Human ENPEP / Aminopeptidase A. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ENPEP. It may not necessarily be applicable to this product.

NCBI GI #
132814467
NCBI GeneID
2028
NCBI Accession #
NP_001968.3
UniProt Primary Accession #
Q07075
UniProt Secondary Accession #
Q504U2
UniProt Related Accession #
Q07075
GenBank Nucleotide #
NM_001977.3
NCBI Official Full Name
glutamyl aminopeptidase
NCBI Official Synonym Full Names
glutamyl aminopeptidase (aminopeptidase A)
NCBI Official Symbol
ENPEP
NCBI Official Synonym Symbols
APA; CD249; gp160
UniProt Protein Name
Glutamyl aminopeptidase
UniProt Synonym Protein Names
Aminopeptidase A; AP-A; Differentiation antigen gp160; CD_antigen: CD249
UniProt Gene Name
ENPEP
UniProt Synonym Gene Names
EAP; AP-A
UniProt Entry Name
AMPE_HUMAN
NCBI Protein Information
glutamyl aminopeptidase; EAP; AP-A; aminopeptidase A; differentiation antigen gp160

UniProt Comments for ENPEP

ENPEP: Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells. Belongs to the peptidase M1 family.

Protein type: Membrane protein, integral; EC 3.4.11.7; Protease

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: integral to plasma membrane; lysosomal membrane; apical part of cell; apical plasma membrane; plasma membrane; cytoplasmic vesicle; brush border; external side of plasma membrane

Molecular Function: metallopeptidase activity; zinc ion binding; aminopeptidase activity

Biological Process: cell proliferation; cell migration; cellular protein metabolic process; cell-cell signaling; angiotensin catabolic process in blood; angiogenesis; angiotensin maturation; proteolysis; glomerulus development; regulation of systemic arterial blood pressure by renin-angiotensin
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Research Articles on ENPEP

1. This study suggests a role for GAP in the neoplastic development of renal tumours and provides additional data for considering the activity and expression of this enzyme of interest in the diagnosis and prognosis of renal neoplasms.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ENPEP antibody

 Reference Product  PubMed Publications
 ANPEP antibody  >1 publications with ENPEP and ANPEP

Pathways associated with anti-ENPEP antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram

Diseases associated with anti-ENPEP antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >2 publications with ENPEP and Disease Models, Animal
 Kidney Diseases Antibodies  >2 publications with ENPEP and Kidney Diseases
 Congenital Abnormalities Antibodies  >1 publications with ENPEP and Congenital Abnormalities
 Cell Transformation, Neoplastic Antibodies  >1 publications with ENPEP and Cell Transformation, Neoplastic
 Acute Kidney Injury Antibodies  >1 publications with ENPEP and Acute Kidney Injury
 Fibrosis Antibodies  >1 publications with ENPEP and Fibrosis

Organs/Tissues associated with anti-ENPEP antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >5 publications with ENPEP and Bone Marrow
 Kidney Antibodies  >5 publications with ENPEP and Kidney
 Liver Antibodies  >2 publications with ENPEP and Liver
 Thymus Antibodies  >2 publications with ENPEP and Thymus
 Heart Antibodies  >2 publications with ENPEP and Heart
 Placenta Antibodies  >2 publications with ENPEP and Placenta
 Connective Tissue Antibodies  >1 publications with ENPEP and Connective Tissue
 Spleen Antibodies  >1 publications with ENPEP and Spleen
 Pancreas Antibodies  >1 publications with ENPEP and Pancreas
 Eye Antibodies  >1 publications with ENPEP and Eye
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