Goat Anti-TSPYL2 Polyclonal Antibody – Cat# MBS244346

Anti-TSPYL2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

TSPYL2 Antibody – Goat Polyclonal

Name: TSPYL2 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS244346
Price: 625 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244346

MBS244346 is an antibody targeting TSPYL2. Also known as Goat Polyclonal to Human TSPYL2 / DENTT. Reactive in Gibbon, Gorilla, Human, Monkey. Host: Goat. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

TSPYL2 / DENTT, Polyclonal Antibody

Full Product Name

Goat Polyclonal to Human TSPYL2 / DENTT

Product Gene Name

anti-TSPYL2 antibody

Product Synonym Gene Name

DENTT

Product Synonym Names

Anti-TSPYL2 / DENTT Antibody (C-Terminus) IHC-plus; TSPYL2; CDA1; CINAP; DENTT; CTCL; CTCL-associated antigen se20-4; Cell division autoantigen 1; HRIHFB2216; Nuclear protein of 79 kDa; NP79; TSPY-like protein 2; SE20-4; SE204; TSPY-like 2; CTCL tumor antigen se20-4; TSPX; Human TSPYL2; DENTT

Clonality

Polyclonal

Host

Goat

Species Reactivity

Gibbon, Gorilla, Human, Monkey

Form/Format

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

Purity/Purification

Immunoaffinity Purified

Concentration

0.5 mg/ml (lot specific)

Specificity

Human TSPYL2.

Preparation and Storage

Store at -20 degree C. Minimize freezing and thawing.

Molecular Weight

79,435 Da

OMIM

300564

3D Structure

ModBase 3D Structure for Q9H2G4

Target Species

Human

Immunogen Description

Synthetic peptide C-PNGWANPGKRGKTG from the C-terminus of human TSPYL2 (NP_071400.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Panda, Dog, Horse (86%).

Immunogen Type

Synthetic peptide

Immunogen

TSPYL2 / DENTT antibody was raised against synthetic peptide C-PNGWANPGKRGKTG from the C-terminus of human TSPYL2 (NP_071400.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Panda, Dog, Horse (86%).

Antigen Modification

C-Terminus

Applications Tested/Suitable for anti-TSPYL2 antibody

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

Application Notes for anti-TSPYL2 antibody

ELISA (1:8000), IHC-P (5 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:8000. Western blot: Preliminary experiments in Human Testis lysates gave no specific signal but low background (at antibody concentration up to 1 ug/ml).

Other Notes

Small volumes of anti-TSPYL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TSPYL2. It may not necessarily be applicable to this product.

NCBI GI #

11545835

NCBI GeneID

64061

NCBI Accession #

NP_071400.1

UniProt Primary Accession #

Q9H2G4

UniProt Secondary Accession #

O94799; Q96DG7; Q9BZW6

UniProt Related Accession #

Q9H2G4

GenBank Nucleotide #

NM_022117.3

NCBI Official Full Name

testis-specific Y-encoded-like protein 2

NCBI Official Synonym Full Names

TSPY-like 2

NCBI Official Symbol

TSPYL2

NCBI Official Synonym Symbols

CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216

UniProt Protein Name

Testis-specific Y-encoded-like protein 2

UniProt Synonym Protein Names

Cell division autoantigen 1; Cutaneous T-cell lymphoma-associated antigen se20-4; CTCL-associated antigen se20-4; Differentially-expressed nucleolar TGF-beta1 target protein; Nuclear protein of 79 kDa; NP79

Protein Family

Testis-specific Y-encoded-like protein

UniProt Gene Name

TSPYL2

UniProt Synonym Gene Names

CDA1; DENTT; TSPX; TSPY-like protein 2; CTCL-associated antigen se20-4; NP79

UniProt Entry Name

TSYL2_HUMAN

NCBI Protein Information

testis-specific Y-encoded-like protein 2; TSPY-like protein 2; CTCL tumor antigen se20-4; nuclear protein of 79 kDa; cell division autoantigen 1; CTCL-associated antigen se20-4; testis-specific protein Y encoded-like 2; CASK-interacting nucleosome assembly protein; cutaneous T-cell lymphoma-associated antigen se20-4; differentially expressed nucleolar TGF-beta1 target; cutaneous T-cell lymphoma-associated tumor antigen se20-4; differentially-expressed nucleolar TGF-beta1 target protein

NCBI Summary for TSPYL2

This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]

UniProt Comments for TSPYL2

TSPYL2: Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. Belongs to the nucleosome assembly protein (NAP) family.

Protein type: Transcription regulation; DNA replication

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: nucleoplasm; centrosome; cytoplasm; plasma membrane; nucleolus; nucleus

Molecular Function: rDNA binding

Biological Process: transcription, DNA-dependent; unfolded protein response; regulation of signal transduction; chromatin modification; cell cycle; negative regulation of cell cycle; nucleosome assembly; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; regulation of transcription, DNA-dependent; negative regulation of DNA replication; negative regulation of cell growth; regulation of protein kinase activity

Research Articles on TSPYL2

1. The oncogenic events leading to an ectopic activation of TSPY and/or inactivating mutation/epigenetic silencing of TSPX could collectively contribute to the sexual dimorphism(s) in HCC and related liver cancers in male-biased manners.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TSPYL2 antibody

Reference Product	PubMed Publications
TGFB1 antibody	>2 publications with TSPYL2 and TGFB1

Pathways associated with anti-TSPYL2 antibody

Products by Pathway	Pathway Diagram
IRE1alpha Activates Chaperones Pathway antibodies	IRE1alpha Activates Chaperones Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Unfolded Protein Response (UPR) Pathway antibodies	Unfolded Protein Response (UPR) Pathway Diagram
XBP1(S) Activates Chaperone Genes Pathway antibodies	XBP1(S) Activates Chaperone Genes Pathway Diagram

Diseases associated with anti-TSPYL2 antibody

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>2 publications with TSPYL2 and Heart Diseases
Carcinoma, Hepatocellular Antibodies	>1 publications with TSPYL2 and Carcinoma, Hepatocellular
Leiomyoma Antibodies	>1 publications with TSPYL2 and Leiomyoma
Adenocarcinoma Antibodies	>1 publications with TSPYL2 and Adenocarcinoma
Hypertrophy Antibodies	>1 publications with TSPYL2 and Hypertrophy
Cardiovascular Diseases Antibodies	>1 publications with TSPYL2 and Cardiovascular Diseases
Kidney Diseases Antibodies	>1 publications with TSPYL2 and Kidney Diseases
Endometrial Neoplasms Antibodies	>1 publications with TSPYL2 and Endometrial Neoplasms

Organs/Tissues associated with anti-TSPYL2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with TSPYL2 and Brain
Testis Antibodies	>2 publications with TSPYL2 and Testis
Kidney Antibodies	>1 publications with TSPYL2 and Kidney
Connective Tissue Antibodies	>1 publications with TSPYL2 and Connective Tissue
Uterus Antibodies	>1 publications with TSPYL2 and Uterus
Embryonic Tissue Antibodies	>1 publications with TSPYL2 and Embryonic Tissue
Placenta Antibodies	>1 publications with TSPYL2 and Placenta
Blood Antibodies	>1 publications with TSPYL2 and Blood