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GCGR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244349

The Glucagon Receptor mediates the effects of glucagon in controlling glucose metabolism by initiating a cascade of events that regulate the amount of glucose released from the liver into the bloodstream. Glucagon generally functions as a counterregulatory… More details

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Product Overview

Online Datasheet in PDF
Product Name
GCGR / Glucagon Receptor, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human GCGR / Glucagon Receptor
Product Gene Name
anti-GCGR antibody
Product Synonym Names
Anti-GCGR / Glucagon Receptor Antibody (N-Terminus) IHC-plus; GCGR; GL-R; Glucagon receptor; GGR; Human GCGR; Glucagon Receptor
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Human
Predicted Reactivity: Gorilla, Monkey, Bovine, Dog, Hamster, Horse (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human Glucagon Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
54,009 Da
OMIM
138033
3D Structure
ModBase 3D Structure for P47871
Target Species
Human
Immunogen Description
Synthetic 20 amino acid peptide from N-terminal extracellular domain of human Glucagon Receptor. Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Gorilla, Monkey (95%); Hamster, Bovine, Dog, Horse (90%); Mouse, Rat (85%).
Immunogen Type
Synthetic peptide
Immunogen
GCGR / Glucagon Receptor antibody was raised against synthetic 20 amino acid peptide from N-terminal extracellular domain of human Glucagon Receptor. Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Gorilla, Monkey (95%); Hamster, Bovine, Dog, Horse (90%); Mouse, Rat (85%).
Antigen Modification
N-Terminus

Product Categories/Family for anti-GCGR antibody

Family: GPCR; Subfamily: Glucagon
Applications Tested/Suitable for anti-GCGR antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-GCGR antibody
IHC-P (2 - 5 ug/ml)

Immunohistochemistry (IHC) of anti-GCGR antibody

Anti-GCGR / Glucagon Receptor antibody IHC of human Adipose, Liposarcoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GCGR Polyclonal Antibody – Cat# MBS244349

Immunohistochemistry (IHC) of anti-GCGR antibody

Human, Adipocyte: Formalin-Fixed Paraffin-Embedded (FFPE)
Rabbit Anti-GCGR Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244349

Immunohistochemistry (IHC) of anti-GCGR antibody

Anti-GCGR / Glucagon Receptor antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GCGR Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244349

Immunohistochemistry (IHC) of anti-GCGR antibody

Anti-GCGR / Glucagon Receptor antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GCGR Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244349

Other Notes

Small volumes of anti-GCGR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GCGR purchase

MBS244349 is an antibody targeting GCGR. Also known as Rabbit Polyclonal to Human GCGR / Glucagon Receptor. Reactive in Gibbon, Human
Predicted Reactivity: Gorilla, Monkey, Bovine, Dog, Hamster, Horse (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GCGR. It may not necessarily be applicable to this product.

NCBI GI #
4503947
NCBI GeneID
2642
NCBI Accession #
NP_000151.1
UniProt Primary Accession #
P47871
UniProt Secondary Accession #
Q2M3M5
UniProt Related Accession #
P47871
GenBank Nucleotide #
NM_000160.4
NCBI Official Full Name
glucagon receptor
NCBI Official Synonym Full Names
glucagon receptor
NCBI Official Symbol
GCGR
NCBI Official Synonym Symbols
GGR; GL-R
UniProt Protein Name
Glucagon receptor
Protein Family
Glucagon receptor
UniProt Gene Name
GCGR
UniProt Synonym Gene Names
GL-R
UniProt Entry Name
GLR_HUMAN
NCBI Protein Information
glucagon receptor

NCBI Summary for GCGR

The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]

UniProt Comments for GCGR

GCGR: This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane; endosome

Molecular Function: guanyl-nucleotide exchange factor activity; peptide hormone binding; glucagon receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; response to starvation; generation of precursor metabolites and energy; exocytosis; hormone-mediated signaling; regulation of blood pressure; energy reserve metabolic process; glucose homeostasis; G-protein signaling, adenylate cyclase activating pathway; response to nutrient; positive regulation of GTPase activity

Disease: Diabetes Mellitus, Noninsulin-dependent
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Research Articles on GCGR

1. crystal structure of the seven transmembrane helical domain of human GCGR at 3.4 A resolution, and a hybrid model of glucagon bound to GCGR to understand the molecular recognition of the receptor for its native ligand

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GCGR antibody

 Reference Product  PubMed Publications
 GCG antibody  >5 publications with GCGR and GCG
 PTH antibody  >1 publications with GCGR and PTH

Pathways associated with anti-GCGR antibody

 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Glucagon Signaling In Metabolic Regulation Pathway antibodies  Glucagon Signaling In Metabolic Regulation Pathway Diagram

Diseases associated with anti-GCGR antibody

 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >16 publications with GCGR and Hyperplasia
 Weight Loss Antibodies  >9 publications with GCGR and Weight Loss
 Fatty Liver Antibodies  >6 publications with GCGR and Fatty Liver
 Liver Diseases Antibodies  >6 publications with GCGR and Liver Diseases
 Cardiovascular Diseases Antibodies  >4 publications with GCGR and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >2 publications with GCGR and Liver Neoplasms
 Inflammation Antibodies  >2 publications with GCGR and Inflammation
 Necrosis Antibodies  >2 publications with GCGR and Necrosis
 Hypertrophy Antibodies  >2 publications with GCGR and Hypertrophy
 Drug-Induced Liver Injury Antibodies  >2 publications with GCGR and Drug-Induced Liver Injury

Organs/Tissues associated with anti-GCGR antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >31 publications with GCGR and Liver
 Pancreas Antibodies  >20 publications with GCGR and Pancreas
 Kidney Antibodies  >4 publications with GCGR and Kidney
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