Rabbit Anti-FPR3 Polyclonal Antibody – Cat# MBS244368

Anti-FPR3 / FPRH2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

FPR3 Antibody – Rabbit Polyclonal

Name: FPR3 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS244368
Price: 630 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244368

FPRL2 is a Chemoattractant Receptor involved in the transduction of signals in myeloid cells. Although it is structurally homologous to FPRL1, human FPRL2 does not recognize the N-formylmethionyl peptides (FMLP) as ligands and is not expressed in neutrophils. More details

$630 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FPR3 / FPRL2, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human FPR3 / FPRL2

Product Gene Name

anti-FPR3 antibody

Product Synonym Gene Name

FPRL2

Product Synonym Names

Anti-FPR3 / FPRL2 Antibody (Transmembrane Domain) IHC-plus; FPR3; FMLP-related receptor II; Formyl peptide receptor 3; Formyl peptide receptor-like 2; FPRL2; FML2_HUMAN; FMLP-R-II; FMLPY; FPRH1; FPRH2; N-formyl peptide receptor 3; N-formyl receptor-like 2; RMLP-R-I; Human FPR3; FPRL2

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Chimpanzee, Gorilla, Human, Monkey, Orangutan
Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human FPR3 / FPRH2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except FPR2 (61%).

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

39,965 Da

OMIM

136539

3D Structure

ModBase 3D Structure for P25089

Target Species

Human

Immunogen Description

Synthetic 18 amino acid peptide from 2nd transmembrane domain of human FPR3 / FPRH2. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Monkey (100%); Gibbon (94%).

Immunogen Type

Synthetic peptide

Immunogen

FPR3 / FPRL2 antibody was raised against synthetic 18 amino acid peptide from 2nd transmembrane domain of human FPR3 / FPRH2. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Monkey (100%); Gibbon (94%).

Antigen Modification

Transmembrane Domain

Product Categories/Family for anti-FPR3 antibody

Family: GPCR; Subfamily: Chemoattractant

Applications Tested/Suitable for anti-FPR3 antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-FPR3 antibody

IHC-P (8 ug/ml)

Other Notes

Small volumes of anti-FPR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FPR3 purchase

MBS244368 is an antibody targeting FPR3. Also known as Rabbit Polyclonal to Human FPR3 / FPRL2. Reactive in Chimpanzee, Gorilla, Human, Monkey, Orangutan
Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FPR3. It may not necessarily be applicable to this product.

NCBI GI #

38455413

NCBI GeneID

2359

NCBI Accession #

NP_002021.3

UniProt Primary Accession #

P25089

UniProt Related Accession #

P25089

GenBank Nucleotide #

NM_002030.3

NCBI Official Full Name

N-formyl peptide receptor 3

NCBI Official Synonym Full Names

formyl peptide receptor 3

NCBI Official Symbol

FPR3

NCBI Official Synonym Symbols

FMLPY; FPRH1; FPRH2; FPRL2; RMLP-R-I; FML2_HUMAN

UniProt Protein Name

N-formyl peptide receptor 3

UniProt Synonym Protein Names

FMLP-related receptor II; FMLP-R-II; Formyl peptide receptor-like 2

Protein Family

FK506-binding nuclear protein

UniProt Gene Name

FPR3

UniProt Synonym Gene Names

FPRH1; FPRL2; FMLP-R-II

UniProt Entry Name

FPR3_HUMAN

NCBI Protein Information

N-formyl peptide receptor 3; FMLP-R-II; FMLP-related receptor II; formyl peptide receptor-like 2

UniProt Comments for FPR3

FPR3: Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Motility/polarity/chemotaxis; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19q13.3-q13.4

Cellular Component: integral to membrane; plasma membrane

Molecular Function: N-formyl peptide receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; chemotaxis; signal transduction; cell motility

Research Articles on FPR3

1. The demonstrated proper folding and functionality of the cell-free produced human FPR3 opens a new avenue for the fast and efficient generation of human FPRs (and even other GPCRs) for structural and functional analysis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FPR3 antibody

Reference Product	PubMed Publications
FPR1 antibody	>18 publications with FPR3 and FPR1
ANXA1 antibody	>3 publications with FPR3 and ANXA1
HEBP1 antibody	>1 publications with FPR3 and HEBP1

Pathways associated with anti-FPR3 antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway antibodies	Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies	Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-FPR3 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>9 publications with FPR3 and Inflammation
Lung Diseases Antibodies	>2 publications with FPR3 and Lung Diseases
Stomach Diseases Antibodies	>2 publications with FPR3 and Stomach Diseases
Edema Antibodies	>2 publications with FPR3 and Edema
Disease Models, Animal Antibodies	>2 publications with FPR3 and Disease Models, Animal
Alzheimer Disease Antibodies	>1 publications with FPR3 and Alzheimer Disease
Intestinal Diseases Antibodies	>1 publications with FPR3 and Intestinal Diseases

Organs/Tissues associated with anti-FPR3 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>14 publications with FPR3 and Blood
Lung Antibodies	>3 publications with FPR3 and Lung
Uterus Antibodies	>1 publications with FPR3 and Uterus
Spleen Antibodies	>1 publications with FPR3 and Spleen
Bone Marrow Antibodies	>1 publications with FPR3 and Bone Marrow
Brain Antibodies	>1 publications with FPR3 and Brain