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GPR119 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244414

GPR119, a Lysophospholipid/Lysosphingolipid Receptor, has been shown to affect insulin secretion from pancreatic beta cells. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GPR119, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human GPR119
Product Gene Name
Product Synonym Names
Anti-GPR119 Antibody (aa186-235) IHC-plus; GPR119; G-protein coupled receptor 2; GPCR2; HGPCR2; G protein-coupled receptor 119; G-protein coupled receptor 119; Human GPR119
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
GPR119 Antibody detects endogenous levels of total GPR119 protein.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
36,889 Da
OMIM
300513
3D Structure
ModBase 3D Structure for Q8TDV5
Target Species
Human
Immunogen Description
Synthetic peptide from human GPR119 (aa186-235).
Immunogen
GPR119 antibody was raised against synthetic peptide from human GPR119 (aa186-235).
Antigen Modification
aa186-235
Applications Tested/Suitable for anti-GPR119 antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-GPR119 antibody
ELISA (1:1000), IF (1:100 - 1:500), IHC-P (5 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-GPR119 antibody

Anti-GPR119 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-GPR119 Polyclonal Antibody – Cat# MBS244414

Immunofluorescence (IF) of anti-GPR119 antibody

Immunofluorescence of MCF7 cells, using GPR119 Antibody. The picture on the right is treated with the synthesized peptide.
Rabbit Anti-GPR119 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS244414

Western Blot (WB) of anti-GPR119 antibody

Western blot of extracts from K562 cells, using GPR119 Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-GPR119 Polyclonal Antibody, Western Blot (WB) – Cat# MBS244414

Other Notes

Small volumes of anti-GPR119 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GPR119 purchase

MBS244414 is an antibody targeting GPR119. Also known as Rabbit Polyclonal (IgG) to Human GPR119. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GPR119. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
glucose-dependent insulinotropic receptor
NCBI Official Synonym Full Names
G protein-coupled receptor 119
NCBI Official Symbol
GPR119
NCBI Official Synonym Symbols
GPCR2
UniProt Protein Name
Glucose-dependent insulinotropic receptor
UniProt Synonym Protein Names
G-protein coupled receptor 119
UniProt Gene Name
GPR119
UniProt Entry Name
GP119_HUMAN
NCBI Protein Information
glucose-dependent insulinotropic receptor; G-protein coupled receptor 2

NCBI Summary for GPR119

This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]
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UniProt Comments for GPR119

GPR119: Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: Xq26.1

Cellular Component: plasma membrane; integral to membrane; receptor complex

Molecular Function: G-protein coupled receptor activity; phosphatidylcholine binding

Biological Process: G-protein coupled receptor protein signaling pathway; insulin secretion
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-GPR119 antibody

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >38 publications with GPR119 and Pancreas
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