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VMD2L3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244425

VMD2L3, a bestrophin, is an anion channel. The VMD2 gene underlying vitelliform macular dystrophy and the 3 VMD2-like genes, VMD2L1, VMD2L2, and VMD2L3, encode transmembrane (TM) spanning proteins that share a homology region with a high content of aromatic… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
VMD2L3 / BEST3, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human VMD2L3 / BEST3
Product Gene Name
Product Synonym Gene Name
BEST3
Product Synonym Names
Anti-VMD2L3 / BEST3 Antibody (Internal) IHC-plus; BEST3; Bestrophin-3; VMD2L3; Bestrophin 3; Human VMD2L3; BEST3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Human
Predicted Reactivity: Monkey, Bat, Bovine, Hamster, Pig (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human BEST3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
63,378 Da
OMIM
607337
3D Structure
ModBase 3D Structure for Q8N1M1
Target Species
Human
Immunogen Description
Synthetic 20 amino acid peptide from internal region of human BEST3. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset, Bat (95%); Hamster, Elephant, Panda, Bovine, Pig (90%); Dog, Rabbit (85%).
Immunogen Type
Synthetic peptide
Immunogen
VMD2L3 / BEST3 antibody was raised against synthetic 20 amino acid peptide from internal region of human BEST3. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset, Bat (95%); Hamster, Elephant, Panda, Bovine, Pig (90%); Dog, Rabbit (85%); Mouse, Rat, Horse, Platypus (80%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-VMD2L3 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-VMD2L3 antibody
IHC-P (2.5 - 5 ug/ml)

Immunohistochemistry (IHC) of anti-VMD2L3 antibody

Anti-BEST3 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-VMD2L3 Polyclonal Antibody – Cat# MBS244425

Other Notes

Small volumes of anti-VMD2L3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VMD2L3 purchase

MBS244425 is an antibody targeting VMD2L3. Also known as Rabbit Polyclonal to Human VMD2L3 / BEST3. Reactive in Gibbon, Gorilla, Human
Predicted Reactivity: Monkey, Bat, Bovine, Hamster, Pig (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for VMD2L3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
bestrophin-3 isoform 1
NCBI Official Synonym Full Names
bestrophin 3
NCBI Official Symbol
BEST3
NCBI Official Synonym Symbols
VMD2L3
UniProt Protein Name
Bestrophin-3
UniProt Synonym Protein Names
Vitelliform macular dystrophy 2-like protein 3
UniProt Gene Name
BEST3
UniProt Synonym Gene Names
VMD2L3
UniProt Entry Name
BEST3_HUMAN
NCBI Protein Information
bestrophin-3; vitelliform macular dystrophy 2-like 3; vitelliform macular dystrophy 2-like protein 3

NCBI Summary for VMD2L3

BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008]
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UniProt Comments for VMD2L3

VMD2L3: Forms calcium-sensitive chloride channels. Permeable to bicarbonate. Belongs to the bestrophin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: plasma membrane

Molecular Function: chloride channel activity

Biological Process: negative regulation of ion transport
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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