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AGO1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244454

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in… More details

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Product Overview

Online Datasheet in PDF
Product Name
AGO1 / EIF2C, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human AGO1 / EIF2C
Product Gene Name
anti-AGO1 antibody
Product Synonym Gene Name
EIF2C
Product Synonym Names
Anti-AGO1 / EIF2C Antibody (Internal) IHC-plus; AGO1; Argonaute 1; EIF-2C 1; EIF2C1; GERP95; EIF2C; EIF2C 1; HAgo1; Q99; Argonaute1; Protein argonaute-1; Human AGO1; EIF2C
Clonality
Polyclonal
Host
Goat
Species Reactivity
Bat, Gibbon, Bovine, Chicken, Dog, Xenopus, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human EIF2C1 / AGO1. This product is not expected to cross-react with EIF2C2, EIF2C3 and EIF2C4.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
97,214 Da
OMIM
606228
3D Structure
ModBase 3D Structure for Q9UL18
Target Species
Human
Immunogen Description
Synthetic peptide C-KNASYNLDPYIQEF from an internal region of human EIF2C1 / AGO1 (NP_036331.1).
Immunogen Type
Synthetic peptide
Immunogen
AGO1 / EIF2C antibody was raised against synthetic peptide C-KNASYNLDPYIQEF from an internal region of human EIF2C1 / AGO1 (NP_036331.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Bat, Horse, Rabbit, Pig, Opossum, Turkey, Chicken, Platypus, Xenopus (100%); Stickleback, Pufferfish, Zebrafish (86%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-AGO1 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-AGO1 antibody
ELISA (1:16000), IHC-P (2.5 - 3.75 ug/ml)

Immunohistochemistry (IHC) of anti-AGO1 antibody

Anti-EIF2C1 / AGO1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Goat Anti-AGO1 Polyclonal Antibody – Cat# MBS244454

Immunohistochemistry (IHC) of anti-AGO1 antibody

Anti-EIF2C1 / AGO1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Goat Anti-AGO1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244454

Other Notes

Small volumes of anti-AGO1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AGO1 purchase

MBS244454 is an antibody targeting AGO1. Also known as Goat Polyclonal to Human AGO1 / EIF2C. Reactive in Bat, Gibbon, Bovine, Chicken, Dog, Xenopus, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for AGO1. It may not necessarily be applicable to this product.

NCBI GI #
6912352
NCBI GeneID
26523
NCBI Accession #
NP_036331.1
UniProt Primary Accession #
Q9UL18
UniProt Secondary Accession #
Q5TA57; Q6P4S0
UniProt Related Accession #
Q9UL18
GenBank Nucleotide #
NM_012199.2
NCBI Official Full Name
protein argonaute-1
NCBI Official Synonym Full Names
argonaute RISC catalytic component 1
NCBI Official Symbol
AGO1
NCBI Official Synonym Symbols
Q99; EIF2C; EIF2C1; GERP95
UniProt Protein Name
Protein argonaute-1
UniProt Synonym Protein Names
Argonaute RISC catalytic component 1; Eukaryotic translation initiation factor 2C 1; eIF-2C 1; eIF2C 1; Putative RNA-binding protein Q99
Protein Family
Protein argonaute
UniProt Gene Name
AGO1
UniProt Synonym Gene Names
EIF2C1; Argonaute1; hAgo1; eIF-2C 1; eIF2C 1
UniProt Entry Name
AGO1_HUMAN
NCBI Protein Information
protein argonaute-1; hAgo1; eIF2C 1; eIF-2C 1; argonaute1; argonaute 1; putative RNA-binding protein Q99; Golgi Endoplasmic Reticulum protein 95 kDa; eukaryotic translation initiation factor 2C, 1

UniProt Comments for AGO1

AGO1: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). Interacts with DDB1, DDX5, DDX6, DHX30, DHX36, DDX47, DICER1, EIF2C2/AGO2, ELAVL1, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, MOV10, PABPC1, PRMT5, RBM4, SART3, TNRC6B, UPF1 and YBX1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with LIMD1, WTIP and AJUBA. Belongs to the argonaute family. Ago subfamily.

Protein type: RNA-binding; Translation

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: nucleoplasm; polysome; cytoplasm; cytosol; ribonucleoprotein complex

Molecular Function: endoribonuclease activity; protein binding; miRNA binding; RNA binding

Biological Process: epidermal growth factor receptor signaling pathway; Notch signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; transcription, DNA-dependent; miRNA-mediated gene silencing, mRNA cleavage; miRNA-mediated gene silencing, negative regulation of translation; innate immune response; gene expression; positive regulation of transcription from RNA polymerase II promoter; posttranscriptional gene silencing
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Research Articles on AGO1

1. Completion of the tetrad, combined with a mutation on a loop adjacent to the active site of hAgo1, results in slicer activity that is substantially enhanced by swapping in the N domain of hAgo2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AGO1 antibody

 Reference Product  PubMed Publications
 EIF2C2 antibody  >52 publications with AGO1 and EIF2C2
 DICER1 antibody  >19 publications with AGO1 and DICER1
 EIF2C4 antibody  >8 publications with AGO1 and EIF2C4
 DDX6 antibody  >4 publications with AGO1 and DDX6
 TARBP2 antibody  >4 publications with AGO1 and TARBP2
 TNRC6A antibody  >3 publications with AGO1 and TNRC6A
 TNRC6B antibody  >3 publications with AGO1 and TNRC6B
 PRKRA antibody  >1 publications with AGO1 and PRKRA

Pathways associated with anti-AGO1 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Ca2+ Pathway antibodies  Ca2+ Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram

Diseases associated with anti-AGO1 antibody

 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >4 publications with AGO1 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >4 publications with AGO1 and Kidney Diseases
 Liver Neoplasms Antibodies  >4 publications with AGO1 and Liver Neoplasms
 Liver Diseases Antibodies  >4 publications with AGO1 and Liver Diseases
 Atherosclerosis Antibodies  >3 publications with AGO1 and Atherosclerosis
 Chromosome Aberrations Antibodies  >3 publications with AGO1 and Chromosome Aberrations
 Necrosis Antibodies  >3 publications with AGO1 and Necrosis
 Neoplasms, Experimental Antibodies  >2 publications with AGO1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >2 publications with AGO1 and Breast Neoplasms
 Disease Models, Animal Antibodies  >2 publications with AGO1 and Disease Models, Animal

Organs/Tissues associated with anti-AGO1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >10 publications with AGO1 and Brain
 Kidney Antibodies  >7 publications with AGO1 and Kidney
 Liver Antibodies  >6 publications with AGO1 and Liver
 Ovary Antibodies  >6 publications with AGO1 and Ovary
 Heart Antibodies  >5 publications with AGO1 and Heart
 Blood Antibodies  >5 publications with AGO1 and Blood
 Lung Antibodies  >4 publications with AGO1 and Lung
 Muscle Antibodies  >4 publications with AGO1 and Muscle
 Eye Antibodies  >4 publications with AGO1 and Eye
 Embryonic Tissue Antibodies  >3 publications with AGO1 and Embryonic Tissue
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