WNT14 Antibody – Rabbit Polyclonal

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region. [provided by RefSeq, Jul 2008]

WNT9A: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Belongs to the Wnt family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q42

Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region

Molecular Function: frizzled binding

Biological Process: embryonic forelimb morphogenesis; Wnt receptor signaling pathway; cell fate commitment; mitotic cell cycle checkpoint; multicellular organismal development; negative regulation of chondrocyte differentiation; Wnt receptor signaling pathway through beta-catenin; negative regulation of caspase activity; embryonic skeletal morphogenesis; neuron differentiation; negative regulation of cell proliferation; cell-cell signaling; positive regulation of smoothened signaling pathway; positive regulation of cell differentiation