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NPY5R Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244471

NPY5R, a Neuropeptide Receptor GPCR, has been suggested to be the main receptor mediating NPY-induced food intake in rats. More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
NPY5R, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human NPY5R
Product Gene Name
anti-NPY5R antibody
Product Synonym Names
Anti-NPY5R Antibody (aa221-270) IHC-plus; NPY5R; NPYR5; NPY5-R; NPYY5; Neuropeptide Y receptor Y5; NPYY5-R; Neuropeptide Y receptor type 5; Neuropeptide Y5 receptor; NPY-Y5 receptor; NPY5 receptor; Y5 receptor; Human NPY5R
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Detects endogenous levels of total NPY5R protein.
Preparation and Storage
Store at -20 degree C for up to one year.
Molecular Weight
50,727 Da
OMIM
602001
3D Structure
ModBase 3D Structure for Q15761
Target Species
Human
Immunogen Description
Synthetic peptide from human NPY5R (aa221-270).
Immunogen
NPY5R antibody was raised against synthetic peptide from human NPY5R (aa221-270).
Antigen Modification
aa221-270

Product Categories/Family for anti-NPY5R antibody

Family: GPCR; Subfamily: Neuropeptide
Applications Tested/Suitable for anti-NPY5R antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-NPY5R antibody
ELISA (1:20000), IF (1:100 - 1:500), IHC-P (2.5 - 5 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-NPY5R antibody

Anti-NPY5R antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Rabbit Anti-NPY5R Polyclonal Antibody – Cat# MBS244471

Immunofluorescence (IF) of anti-NPY5R antibody

Immunofluorescence of A549 cells, using NPY5R Antibody. The picture on the right is treated with the synthesized peptide.
Rabbit Anti-NPY5R Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS244471

Western Blot (WB) of anti-NPY5R antibody

Western blot of extracts from COLO/Jurkat/HepG2 cells, using antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-NPY5R Polyclonal Antibody, Western Blot (WB) – Cat# MBS244471

Other Notes

Small volumes of anti-NPY5R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NPY5R purchase

MBS244471 is an antibody targeting NPY5R. Also known as Rabbit Polyclonal (IgG) to Human NPY5R. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NPY5R. It may not necessarily be applicable to this product.

NCBI GI #
5453796
NCBI GeneID
4889
NCBI Accession #
NP_006165.1
UniProt Primary Accession #
Q15761
UniProt Secondary Accession #
Q6GTR7; Q92916
UniProt Related Accession #
Q15761
GenBank Nucleotide #
NM_006174.2
NCBI Official Full Name
neuropeptide Y receptor type 5
NCBI Official Synonym Full Names
neuropeptide Y receptor Y5
NCBI Official Symbol
NPY5R
NCBI Official Synonym Symbols
NPYR5; NPY5-R; NPYY5-R
UniProt Protein Name
Neuropeptide Y receptor type 5
UniProt Synonym Protein Names
NPY-Y5 receptor; NPYY5-R; Y5 receptor
Protein Family
Neuropeptide Y receptor
UniProt Gene Name
NPY5R
UniProt Synonym Gene Names
NPYR5; NPY5-R; NPYY5-R; Y5 receptor
UniProt Entry Name
NPY5R_HUMAN
NCBI Protein Information
neuropeptide Y receptor type 5; Y5 receptor; NPY-Y5 receptor

UniProt Comments for NPY5R

NPY5R: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q31-q32

Cellular Component: neuron projection; integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: peptide YY receptor activity; pancreatic polypeptide receptor activity; neuropeptide Y receptor activity

Biological Process: generation of ovulation cycle rhythm; G-protein coupled receptor protein signaling pathway; synaptic transmission; negative regulation of glutamate secretion; eating behavior; neuropeptide signaling pathway; positive regulation of acute inflammatory response; positive regulation of smooth muscle cell proliferation; negative regulation of synaptic transmission, GABAergic; negative regulation of apoptosis
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Research Articles on NPY5R

1. these data highlight a novel mechanism by which NPY may promote breast cancer progression, and further implicate a pathological role of the NPY Y5R.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NPY5R antibody

 Reference Product  PubMed Publications
 NPY1R antibody  >17 publications with NPY5R and NPY1R
 NPY antibody  >14 publications with NPY5R and NPY
 NPY2R antibody  >12 publications with NPY5R and NPY2R
 POMC antibody  >3 publications with NPY5R and POMC
 PPYR1 antibody  >2 publications with NPY5R and PPYR1
 PPY antibody  >1 publications with NPY5R and PPY
 PYY antibody  >1 publications with NPY5R and PYY

Pathways associated with anti-NPY5R antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-NPY5R antibody

 Disease Name  Pubmed Publications
 Obesity Antibodies  >11 publications with NPY5R and Obesity
 Nervous System Diseases Antibodies  >5 publications with NPY5R and Nervous System Diseases
 Weight Loss Antibodies  >4 publications with NPY5R and Weight Loss
 Brain Diseases Antibodies  >3 publications with NPY5R and Brain Diseases
 Hypertension Antibodies  >2 publications with NPY5R and Hypertension
 Seizures Antibodies  >2 publications with NPY5R and Seizures
 Hypertrophy Antibodies  >1 publications with NPY5R and Hypertrophy
 Dyslipidemias Antibodies  >1 publications with NPY5R and Dyslipidemias
 Kidney Diseases Antibodies  >1 publications with NPY5R and Kidney Diseases
 Abnormalities, Multiple Antibodies  >1 publications with NPY5R and Abnormalities, Multiple

Organs/Tissues associated with anti-NPY5R antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with NPY5R and Brain
 Kidney Antibodies  >2 publications with NPY5R and Kidney
 Testis Antibodies  >1 publications with NPY5R and Testis
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