WNT10B Antibody – Rabbit Polyclonal

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]

WNT10B: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Defects in WNT10B are the cause of split-hand/foot malformation type 6 (SHFM6). SHFM is a limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. SHFM6 is a autosomal recessive disorder. Belongs to the Wnt family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region

Molecular Function: frizzled binding; receptor agonist activity

Biological Process: positive regulation of apoptosis; skeletal muscle fiber development; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; neuron differentiation; positive regulation of cell proliferation; positive regulation of epithelial cell differentiation; chondrocyte differentiation; G2/M transition of mitotic cell cycle; cell cycle arrest; positive regulation of transcriptional preinitiation complex assembly; negative regulation of epithelial cell proliferation; smoothened signaling pathway; Wnt receptor signaling pathway; cell fate commitment; sensory perception of taste; protein stabilization; regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of fat cell differentiation; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; regulation of skeletal muscle development; positive regulation of transcription factor activity; lipid metabolic process; positive regulation of anagen; myoblast cell differentiation involved in skeletal muscle regeneration

Disease: Split-hand/foot Malformation 6