Rabbit Anti-DLL1 Polyclonal Antibody – Cat# MBS244485

Anti-DLL1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5-10 ug/ml.

DLL1 Antibody – Rabbit Polyclonal

Name: DLL1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS244485
Price: 625 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244485

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. DLL1 plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

DLL1, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human DLL1

Product Gene Name

anti-DLL1 antibody

Product Synonym Names

Anti-DLL1 Antibody (aa640-700) IHC-plus; DLL1; Delta-like 1 (Drosophila); Delta (Drosophila)-like 1; Drosophila Delta homolog 1; Delta-like protein 1; Delta1; H-Delta-1; DL1; Npa; Human DLL1

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Chimpanzee, Human

Form/Format

PBS, 0.05% BSA, 0.05% sodium azide

Purity/Purification

Protein A Purified

Concentration

0.5 mg/ml (lot specific)

Specificity

Human DLL1

Preparation and Storage

Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.

Molecular Weight

27,355 Da

OMIM

606582

3D Structure

ModBase 3D Structure for O00548

Target Species

Human

Immunogen Description

A portion of amino acids 640-700 of human DLL1 was used as the immunogen.

Immunogen Type

Synthetic peptide

Immunogen

DLL1 antibody was raised against a portion of amino acids 640-700 of human DLL1 was used as the immunogen.

Antigen Modification

aa640-700

Applications Tested/Suitable for anti-DLL1 antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-DLL1 antibody

IHC-P (5 - 10 ug/ml)

Other Notes

Small volumes of anti-DLL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DLL1 purchase

MBS244485 is an antibody targeting DLL1. Also known as Rabbit Polyclonal to Human DLL1. Reactive in Chimpanzee, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DLL1. It may not necessarily be applicable to this product.

NCBI GI #

110735443

NCBI GeneID

28514

NCBI Accession #

NP_005609.3

UniProt Primary Accession #

O00548

UniProt Secondary Accession #

Q9NU41; Q9UJV2; B2RAK7; B5M0B3

UniProt Related Accession #

O00548

GenBank Nucleotide #

NM_005618.3

NCBI Official Full Name

delta-like protein 1

NCBI Official Synonym Full Names

delta-like 1 (Drosophila)

NCBI Official Symbol

DLL1

NCBI Official Synonym Symbols

DL1; Delta; DELTA1

UniProt Protein Name

Delta-like protein 1

UniProt Synonym Protein Names

Drosophila Delta homolog 1; Delta1; H-Delta-1

Protein Family

Delta-like protein

UniProt Gene Name

DLL1

UniProt Synonym Gene Names

Delta1; H-Delta-1

UniProt Entry Name

DLL1_HUMAN

NCBI Protein Information

delta-like protein 1; H-Delta-1; drosophila Delta homolog 1

NCBI Summary for DLL1

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008]

UniProt Comments for DLL1

DLL1: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Interacts with Notch receptors. Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell development/differentiation

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; cytoplasmic vesicle

Molecular Function: protein binding; calcium ion binding; Notch binding

Biological Process: regulation of cell adhesion; Notch signaling pathway; negative regulation of myeloid cell differentiation; negative regulation of interleukin-10 production; Notch receptor processing; cell fate determination; compartment specification; somite specification; cell-cell signaling; negative regulation of auditory receptor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; hemopoiesis; heart looping; determination of left/right symmetry; cell differentiation; inner ear development; positive regulation of Notch signaling pathway

Research Articles on DLL1

1. Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DLL1 antibody

Reference Product	PubMed Publications
NOTCH1 antibody	>107 publications with DLL1 and NOTCH1
NOTCH2 antibody	>38 publications with DLL1 and NOTCH2
JAG1 antibody	>34 publications with DLL1 and JAG1
HES5 antibody	>25 publications with DLL1 and HES5
JAG2 antibody	>19 publications with DLL1 and JAG2
NOTCH3 antibody	>16 publications with DLL1 and NOTCH3
MIB1 antibody	>5 publications with DLL1 and MIB1
ADAM10 antibody	>3 publications with DLL1 and ADAM10

Pathways associated with anti-DLL1 antibody

Products by Pathway	Pathway Diagram
Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies	Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies	Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies	Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies	Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies	Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
Delta-Notch Signaling Pathway antibodies	Delta-Notch Signaling Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies	FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies	NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
Neural Crest Differentiation Pathway antibodies	Neural Crest Differentiation Pathway Diagram

Diseases associated with anti-DLL1 antibody

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>10 publications with DLL1 and Congenital Abnormalities
Disease Models, Animal Antibodies	>9 publications with DLL1 and Disease Models, Animal
Inflammation Antibodies	>9 publications with DLL1 and Inflammation
Carcinoma Antibodies	>9 publications with DLL1 and Carcinoma
Nervous System Diseases Antibodies	>8 publications with DLL1 and Nervous System Diseases
Necrosis Antibodies	>5 publications with DLL1 and Necrosis
Abnormalities, Multiple Antibodies	>5 publications with DLL1 and Abnormalities, Multiple
Carcinoma, Squamous Cell Antibodies	>4 publications with DLL1 and Carcinoma, Squamous Cell
Lung Diseases Antibodies	>4 publications with DLL1 and Lung Diseases
Liver Neoplasms Antibodies	>3 publications with DLL1 and Liver Neoplasms

Organs/Tissues associated with anti-DLL1 antibody

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>40 publications with DLL1 and Embryonic Tissue
Brain Antibodies	>36 publications with DLL1 and Brain
Lung Antibodies	>15 publications with DLL1 and Lung
Intestine Antibodies	>11 publications with DLL1 and Intestine
Kidney Antibodies	>7 publications with DLL1 and Kidney
Eye Antibodies	>6 publications with DLL1 and Eye
Skin Antibodies	>6 publications with DLL1 and Skin
Ear Antibodies	>5 publications with DLL1 and Ear
Connective Tissue Antibodies	>4 publications with DLL1 and Connective Tissue
Lymph Node Antibodies	>3 publications with DLL1 and Lymph Node