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HTR7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244533

5-HT7 Receptor (HTR7)is a serotonin receptor with several functions, including regulation of the circadian rhythm and mediation of smooth-muscle relaxation in the vasculature and GI tract. HTR7 has been implicated in depression, autistic, and other… More details

$650 / 0.05 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
HTR7 / 5-HT7 Receptor, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human HTR7 / 5-HT7 Receptor
Product Gene Name
anti-HTR7 antibody
Product Synonym Names
Anti-HTR7 / 5-HT7 Receptor Antibody (C-Terminus) IHC-plus; HTR7; 5-HT7; 5-HT7 receptor; 5-HT-7; 5-hydroxytryptamine 7 receptor; 5HT7; 5-HT-X; 5-hydroxytryptamine receptor 7; 5HT7 Receptor; HT7; Serotonin 5-HT7 receptor; Serotonin receptor 7; Human HTR7; 5-HT7 Receptor
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human 5HT7 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
47,984 Da
OMIM
182137
3D Structure
ModBase 3D Structure for P34969
Target Species
Human
Immunogen Description
Synthetic 20 amino acid peptide from C-terminus of human 5HT7 Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (95%); Marmoset (85%).
Immunogen Type
Synthetic peptide
Immunogen
HTR7 / 5-HT7 Receptor antibody was raised against synthetic 20 amino acid peptide from C-terminus of human 5HT7 Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (95%); Marmoset (85%).
Antigen Modification
C-Terminus

Product Categories/Family for anti-HTR7 antibody

Family: GPCR; Subfamily: Serotonin
Applications Tested/Suitable for anti-HTR7 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-HTR7 antibody
IHC-P (2 - 3 ug/ml)

Immunohistochemistry (IHC) of anti-HTR7 antibody

Anti-HTR7 / 5-HT7 Receptor antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-HTR7 Polyclonal Antibody – Cat# MBS244533

Immunohistochemistry (IHC) of anti-HTR7 antibody

Anti-5HT7 Receptor antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-HTR7 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244533

Immunohistochemistry (IHC) of anti-HTR7 antibody

Anti-HTR7 / 5-HT7 Receptor antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-HTR7 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244533

Other Notes

Small volumes of anti-HTR7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HTR7 purchase

MBS244533 is an antibody targeting HTR7. Also known as Rabbit Polyclonal to Human HTR7 / 5-HT7 Receptor. Reactive in Gibbon, Gorilla, Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HTR7. It may not necessarily be applicable to this product.

NCBI GI #
10880129
NCBI GeneID
3363
NCBI Accession #
NP_062873.1
UniProt Primary Accession #
P34969
UniProt Secondary Accession #
P78336; P78372; P78516; Q5VX01; Q5VX02; Q5VX03; B5BUP6
UniProt Related Accession #
P34969
GenBank Nucleotide #
NM_019859.3
NCBI Official Full Name
5-hydroxytryptamine receptor 7 isoform d
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
NCBI Official Symbol
HTR7
NCBI Official Synonym Symbols
5-HT7
UniProt Protein Name
5-hydroxytryptamine receptor 7
UniProt Synonym Protein Names
5-HT-X; Serotonin receptor 7
Protein Family
5-hydroxytryptamine receptor
UniProt Gene Name
HTR7
UniProt Synonym Gene Names
5-HT-7; 5-HT7
UniProt Entry Name
5HT7R_HUMAN
NCBI Protein Information
5-hydroxytryptamine receptor 7; 5-HT-7; 5-HT-X; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)

NCBI Summary for HTR7

The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]
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UniProt Comments for HTR7

5-HT(7): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q21-q24

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: serotonin receptor activity

Biological Process: circadian rhythm; synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; vasoconstriction; smooth muscle contraction; blood circulation; serotonin receptor signaling pathway
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Research Articles on HTR7

1. Serotonin skews human macrophage polarization through HTR2B and HTR7.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HTR7 antibody

 Reference Product  PubMed Publications
 HTR6 antibody  >8 publications with HTR7 and HTR6
 HTR4 antibody  >6 publications with HTR7 and HTR4
 DRD5 antibody  >1 publications with HTR7 and DRD5

Pathways associated with anti-HTR7 antibody

 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with anti-HTR7 antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >13 publications with HTR7 and Mental Disorders
 Nervous System Diseases Antibodies  >6 publications with HTR7 and Nervous System Diseases
 Inflammation Antibodies  >5 publications with HTR7 and Inflammation
 Schizophrenia Antibodies  >5 publications with HTR7 and Schizophrenia
 Disease Models, Animal Antibodies  >3 publications with HTR7 and Disease Models, Animal
 Muscular Diseases Antibodies  >2 publications with HTR7 and Muscular Diseases
 Pain Antibodies  >2 publications with HTR7 and Pain
 Movement Disorders Antibodies  >1 publications with HTR7 and Movement Disorders
 Anxiety Disorders Antibodies  >1 publications with HTR7 and Anxiety Disorders
 Sleep Disorders Antibodies  >1 publications with HTR7 and Sleep Disorders

Organs/Tissues associated with anti-HTR7 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with HTR7 and Brain
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