CELSR2 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]

CELSR2: Receptor that may have an important role in cell/cell signaling during nervous system formation. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; Cell development/differentiation; GPCR, family 2

Chromosomal Location of Human Ortholog: 1p21

Cellular Component: cytoplasm; plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; calcium ion binding

Biological Process: G-protein coupled receptor protein signaling pathway; cerebrospinal fluid secretion; regulation of cell-cell adhesion; regulation of protein localization; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; neural plate anterioposterior pattern formation; ventricular system development; dendrite morphogenesis; neuron migration; cilium biogenesis; homophilic cell adhesion