ENPP3 Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. [provided by RefSeq, Jul 2008]

ENPP3: Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

Protein type: Phosphodiesterase; Membrane protein, integral; EC 3.6.1.9; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Nucleotide Metabolism - purine; Motility/polarity/chemotaxis; Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.4.1

Chromosomal Location of Human Ortholog: 6q22

Cellular Component: integral to plasma membrane; perinuclear region of cytoplasm

Molecular Function: nucleotide diphosphatase activity; phosphodiesterase I activity; nucleic acid binding; metal ion binding; nucleoside-triphosphate diphosphatase activity; scavenger receptor activity; polysaccharide binding

Biological Process: receptor-mediated endocytosis; nucleoside triphosphate catabolic process; immune response; phosphate metabolic process; inorganic diphosphate transport