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GPR39 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244598

GPR39 is an Orphan-A GPCR with an unknown ligand. GPR39 is related to the growth hormone secretagogue receptor, which is a receptor for ghrelin. At least three mRNA variants of GPR39 have been reported. More details

$650 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
GPR39, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human GPR39
Product Gene Name
anti-GPR39 antibody
Product Synonym Names
Anti-GPR39 Antibody (C-Terminus) IHC-plus; GPR39; G protein-coupled receptor 39; G-protein coupled receptor 39; Human GPR39
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gorilla, Human
Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human GPR39. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
51,329 Da
OMIM
602886
3D Structure
ModBase 3D Structure for O43194
Target Species
Human
Immunogen Description
Synthetic 16 amino acid peptide from C-terminus of human GPR39. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (94%).
Immunogen Type
Synthetic peptide
Immunogen
GPR39 antibody was raised against synthetic 16 amino acid peptide from C-terminus of human GPR39. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (94%).
Antigen Modification
C-Terminus

Product Categories/Family for anti-GPR39 antibody

Family: GPCR; Subfamily: Orphan-A
Applications Tested/Suitable for anti-GPR39 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-GPR39 antibody
IHC-P (5 ug/ml)

Immunohistochemistry (IHC) of anti-GPR39 antibody

Anti-GPR39 antibody IHC of human hippocampus, neurons of area ca1. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GPR39 Polyclonal Antibody – Cat# MBS244598

Other Notes

Small volumes of anti-GPR39 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GPR39 purchase

MBS244598 is an antibody targeting GPR39. Also known as Rabbit Polyclonal to Human GPR39. Reactive in Gorilla, Human
Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GPR39. It may not necessarily be applicable to this product.

NCBI GI #
4504097
NCBI GeneID
2863
NCBI Accession #
NP_001499.1
UniProt Primary Accession #
O43194
UniProt Secondary Accession #
Q08AS2; Q53R01; B2RC12; B6V9G4
UniProt Related Accession #
O43194
GenBank Nucleotide #
NM_001508.2
NCBI Official Full Name
G-protein coupled receptor 39
NCBI Official Synonym Full Names
G protein-coupled receptor 39
NCBI Official Symbol
GPR39
UniProt Protein Name
G-protein coupled receptor 39
Protein Family
G-protein coupled receptor
UniProt Gene Name
GPR39
UniProt Entry Name
GPR39_HUMAN
NCBI Protein Information
G-protein coupled receptor 39

UniProt Comments for GPR39

GPR39: Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q21-q22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; metal ion binding

Biological Process: G-protein coupled receptor protein signaling pathway
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Research Articles on GPR39

1. Data suggests alterations (down-regulation) of the GPR39 receptor and involvement of CREB-BDNF pathway, possibly triggered by GPR39, as a new pathomechanism of depression

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GPR39 antibody

 Reference Product  PubMed Publications
 MBOAT4 antibody  >1 publications with GPR39 and MBOAT4
 LYPD1 antibody  >1 publications with GPR39 and LYPD1
 GHRL antibody  >1 publications with GPR39 and GHRL

Pathways associated with anti-GPR39 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-GPR39 antibody

 Disease Name  Pubmed Publications
 Weight Gain Antibodies  >9 publications with GPR39 and Weight Gain
 Disease Models, Animal Antibodies  >6 publications with GPR39 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >5 publications with GPR39 and Cardiovascular Diseases
 Weight Loss Antibodies  >3 publications with GPR39 and Weight Loss
 Hypertension Antibodies  >2 publications with GPR39 and Hypertension
 Heart Diseases Antibodies  >2 publications with GPR39 and Heart Diseases
 Inflammation Antibodies  >2 publications with GPR39 and Inflammation
 Esophageal Neoplasms Antibodies  >1 publications with GPR39 and Esophageal Neoplasms
 Anorexia Antibodies  >1 publications with GPR39 and Anorexia
 Carcinoma, Squamous Cell Antibodies  >1 publications with GPR39 and Carcinoma, Squamous Cell

Organs/Tissues associated with anti-GPR39 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >18 publications with GPR39 and Brain
 Pancreas Antibodies  >13 publications with GPR39 and Pancreas
 Kidney Antibodies  >8 publications with GPR39 and Kidney
 Intestine Antibodies  >8 publications with GPR39 and Intestine
 Connective Tissue Antibodies  >7 publications with GPR39 and Connective Tissue
 Liver Antibodies  >7 publications with GPR39 and Liver
 Pituitary Gland Antibodies  >4 publications with GPR39 and Pituitary Gland
 Uterus Antibodies  >3 publications with GPR39 and Uterus
 Eye Antibodies  >3 publications with GPR39 and Eye
 Thyroid Antibodies  >2 publications with GPR39 and Thyroid
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