Rabbit Anti-NR6A1 Polyclonal Antibody – Cat# MBS244624

Anti-NR6A1 / GCNF antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

NR6A1 Antibody – Rabbit Polyclonal

Name: NR6A1 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS244624
Price: 650 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244624

Germ cell nuclear factor (GCNF), a NR6 Germ Cell Nuclear Factor-Like Receptor, has been shown to affect gene expression in embryogenesis and spermatogenesis and is essential for embryonic survival and normal development. Loss of GCNF causes embryonic… More details

$650 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NR6A1 / GCNF, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human NR6A1 / GCNF

Product Gene Name

anti-NR6A1 antibody

Product Synonym Gene Name

GCNF

Product Synonym Names

Anti-NR6A1 / GCNF Antibody (Ligand-binding Domain) IHC-plus; NR6A1; Germ cell nuclear factor; HGCNF; NR61; HRTR; RTR; Ncnf; GCNF; GCNF1; Human NR6A1; GCNF

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Bat, Gibbon, Bovine, Chimpanzee, Chicken, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Predicted Reactivity: Zebrafish (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human NR6A1 / GCNF. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

53,908 Da

OMIM

602778

3D Structure

ModBase 3D Structure for Q15406

Target Species

Human

Immunogen Description

Synthetic 18 amino acid peptide from ligand-binding domain of human NR6A1 / GCNF.

Immunogen Type

Synthetic peptide

Immunogen

NR6A1 / GCNF antibody was raised against synthetic 18 amino acid peptide from ligand-binding domain of human NR6A1 / GCNF. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Bovine, Horse, Rabbit, Pig, Turkey, Chicken, Platypus (100%); Stickleback, Pufferfish, Zebrafish (94%); Xenopus (89%).

Antigen Modification

Ligand-binding Domain

Product Categories/Family for anti-NR6A1 antibody

Family: NHR; Subfamily: NR6 Germ cell nuclear factor-like

Applications Tested/Suitable for anti-NR6A1 antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-NR6A1 antibody

IHC-P (4 ug/ml)

Other Notes

Small volumes of anti-NR6A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NR6A1 purchase

MBS244624 is an antibody targeting NR6A1. Also known as Rabbit Polyclonal to Human NR6A1 / GCNF. Reactive in Bat, Gibbon, Bovine, Chimpanzee, Chicken, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Predicted Reactivity: Zebrafish (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NR6A1. It may not necessarily be applicable to this product.

NCBI GI #

53729325

NCBI GeneID

2649

NCBI Accession #

NP_201591.2

UniProt Primary Accession #

Q15406

UniProt Secondary Accession #

O00551; O00603; Q5T6F4; Q8NHQ0; Q92898; Q99802

UniProt Related Accession #

Q15406

GenBank Nucleotide #

NM_033334.3

NCBI Official Full Name

nuclear receptor subfamily 6 group A member 1 isoform 1

NCBI Official Synonym Full Names

nuclear receptor subfamily 6, group A, member 1

NCBI Official Symbol

NR6A1

NCBI Official Synonym Symbols

RTR; GCNF; NR61; hRTR; CT150; GCNF1; hGCNF

UniProt Protein Name

Nuclear receptor subfamily 6 group A member 1

UniProt Synonym Protein Names

Germ cell nuclear factor; GCNF; hGCNF; Retinoid receptor-related testis-specific receptor; RTR; hRTR

Protein Family

Nuclear receptor subfamily

UniProt Gene Name

NR6A1

UniProt Synonym Gene Names

GCNF; GCNF; hGCNF; RTR; hRTR

UniProt Entry Name

NR6A1_HUMAN

NCBI Protein Information

nuclear receptor subfamily 6 group A member 1; germ cell nuclear factor variant 1; retinoid receptor-related testis-specific receptor; retinoic acid receptor-related testis-associated receptor

NCBI Summary for NR6A1

This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]

UniProt Comments for NR6A1

NR6A1: Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis. Homodimer. Interacts with UIMC1. Shows highest expression in the germ cells of the adult testis. Belongs to the nuclear hormone receptor family. NR6 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 9q33.3

Cellular Component: nucleoplasm; transcription factor complex

Molecular Function: ligand-dependent nuclear receptor activity; protein homodimerization activity; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity

Biological Process: transcription initiation from RNA polymerase II promoter; cell proliferation; intracellular receptor-mediated signaling pathway; gamete generation; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression; spermatogenesis; negative regulation of transcription from RNA polymerase II promoter

Research Articles on NR6A1

1. Our results show that cellular levels of NR6A1 are correlated with disease progression in prostate cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NR6A1 antibody

Reference Product	PubMed Publications
OCT4 antibody	>12 publications with NR6A1 and OCT4
NCOR1 antibody	>2 publications with NR6A1 and NCOR1
DNMT3B antibody	>1 publications with NR6A1 and DNMT3B

Pathways associated with anti-NR6A1 antibody

Products by Pathway	Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Nuclear Receptor Transcription Pathway antibodies	Nuclear Receptor Transcription Pathway Diagram
POU5F1 (OCT4), SOX2, NANOG Activate Genes Related To Proliferation Pathway antibodies	POU5F1 (OCT4), SOX2, NANOG Activate Genes Related To Proliferation Pathway Diagram
Transcriptional Regulation Of Pluripotent Stem Cells Pathway antibodies	Transcriptional Regulation Of Pluripotent Stem Cells Pathway Diagram

Diseases associated with anti-NR6A1 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>1 publications with NR6A1 and Nervous System Diseases
Liver Diseases Antibodies	>1 publications with NR6A1 and Liver Diseases
Skin Diseases Antibodies	>1 publications with NR6A1 and Skin Diseases
Abnormalities, Drug-Induced Antibodies	>1 publications with NR6A1 and Abnormalities, Drug-Induced
Liver Neoplasms Antibodies	>1 publications with NR6A1 and Liver Neoplasms
Nervous System Malformations Antibodies	>1 publications with NR6A1 and Nervous System Malformations
Weight Loss Antibodies	>1 publications with NR6A1 and Weight Loss

Organs/Tissues associated with anti-NR6A1 antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>33 publications with NR6A1 and Testis
Ovary Antibodies	>16 publications with NR6A1 and Ovary
Embryonic Tissue Antibodies	>14 publications with NR6A1 and Embryonic Tissue
Brain Antibodies	>11 publications with NR6A1 and Brain
Bone Antibodies	>8 publications with NR6A1 and Bone
Liver Antibodies	>6 publications with NR6A1 and Liver
Kidney Antibodies	>4 publications with NR6A1 and Kidney
Placenta Antibodies	>3 publications with NR6A1 and Placenta
Lung Antibodies	>2 publications with NR6A1 and Lung
Prostate Antibodies	>2 publications with NR6A1 and Prostate