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KCNE3 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244650

MBS244650 is an antibody targeting KCNE3. Also known as Goat Polyclonal to Human KCNE3. Reactive in Gibbon, Gorilla, Hamster, HumanPredicted Reactivity: Monkey, Mouse (at least 90% immunogen sequence identity). Host: Goat. More details

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Product Overview

Product Name
KCNE3, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human KCNE3
Product Gene Name
Product Synonym Names
Anti-KCNE3 Antibody (Internal) IHC-plus; KCNE3; MinK-related peptide 2; HOKPP; HYPP; MiRP2; Human KCNE3
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Gorilla, Hamster, Human
Predicted Reactivity: Monkey, Mouse (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human KCNE3.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
11,710 Da
OMIM
gene 613119
3D Structure
ModBase 3D Structure for Q9Y6H6
Target Species
Human
Immunogen Description
Synthetic peptide C-PDNQTEERRASLP from an internal region of human KCNE3 (NP_005463.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Hamster (100%); Monkey, Mouse (92%); Rat, Bovine, Bat (85%).
Immunogen Type
Synthetic peptide
Immunogen
KCNE3 antibody was raised against synthetic peptide C-PDNQTEERRASLP from an internal region of human KCNE3 (NP_005463.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Hamster (100%); Monkey, Mouse (92%); Rat, Bovine, Bat (85%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-KCNE3 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-KCNE3 antibody
ELISA (1:1000), IHC-P (3.75 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:1000. Western blot: Preliminary experiments in Human, Mouse and Rat Skeletal Muscle lysates gave no specific signal but low background (at antibody concentration up to 1 ug/ml).

Immunohistochemistry (IHC) of anti-KCNE3 antibody

Anti-KCNE3 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-KCNE3 Polyclonal Antibody – Cat# MBS244650

Other Notes

Small volumes of anti-KCNE3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNE3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
potassium voltage-gated channel subfamily E member 3
NCBI Official Synonym Full Names
potassium voltage-gated channel, Isk-related family, member 3
NCBI Official Symbol
KCNE3
NCBI Official Synonym Symbols
HYPP; HOKPP; MiRP2
UniProt Protein Name
Potassium voltage-gated channel subfamily E member 3
UniProt Synonym Protein Names
MinK-related peptide 2; Minimum potassium ion channel-related peptide 2; Potassium channel subunit beta MiRP2
UniProt Gene Name
KCNE3
UniProt Entry Name
KCNE3_HUMAN
NCBI Protein Information
potassium voltage-gated channel subfamily E member 3; minK-related peptide 2; potassium channel subunit beta MiRP2; voltage-gated K+ channel subunit MIRP2; minimum potassium ion channel-related peptide 2; cardiac voltage-gated potassium channel accessory subunit

NCBI Summary for KCNE3

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008]
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UniProt Comments for KCNE3

KCNE3: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Belongs to the potassium channel KCNE family.

Protein type: Channel, potassium

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: voltage-gated potassium channel complex

Molecular Function: voltage-gated potassium channel activity; potassium channel regulator activity

Disease: Brugada Syndrome 6
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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