Rabbit Anti-CCNO Polyclonal Antibody – Cat# MBS244665

Anti-CCNO / Cyclin O antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

CCNO Antibody – Rabbit Polyclonal

Name: CCNO Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS244665
Price: 635 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244665

MBS244665 is an antibody targeting CCNO. Also known as Rabbit Polyclonal (IgG) to Human CCNO / UNG2. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CCNO / UNG2, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal (IgG) to Human CCNO / UNG2

Product Gene Name

anti-CCNO antibody

Product Synonym Gene Name

UNG2

Product Synonym Names

Anti-CCNO / UNG2 Antibody IHC-plus; CCNO; CCNU; Cyclin domain containing; Cyclin O; Cyclin U; Uracil-DNA glycosylase 2; UNG2; Cyclin-O; UDG2; Human CCNO; UNG2

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

PBS, 0.02% sodium azide.

Purity/Purification

Purified

Concentration

1 mg/ml (lot specific)

Specificity

Recognizes CyclinO, a 38 kDa member of the cyclin family expressed mainly during the G1 phase.

Preparation and Storage

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Molecular Weight

14,297 Da

OMIM

gene 615872

3D Structure

ModBase 3D Structure for P22674

Target Species

Human

Immunogen Description

13 amino acid peptide sequence near the centre of human Cyclin-O.

Applications Tested/Suitable for anti-CCNO antibody

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

Application Notes for anti-CCNO antibody

IHC-P (5 ug/ml), WB (1 - 2 ug/ml)
Usage: Western Blot: Detects a band of approximately 38kD in human bladder tissue lysate.

Other Notes

Small volumes of anti-CCNO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CCNO. It may not necessarily be applicable to this product.

NCBI GI #

153791755

NCBI GeneID

10309

NCBI Accession #

NP_066970.3

UniProt Primary Accession #

P22674

UniProt Secondary Accession #

Q0P6J2; Q9H6B0; Q9UMD5; A8K1W5

UniProt Related Accession #

P22674

GenBank Nucleotide #

NM_021147.4

NCBI Official Full Name

cyclin-O

NCBI Official Synonym Full Names

cyclin O

NCBI Official Symbol

CCNO

NCBI Official Synonym Symbols

CCNU; UDG2; CILD29

UniProt Protein Name

Cyclin-O

Protein Family

Cyclin

UniProt Gene Name

CCNO

UniProt Entry Name

CCNO_HUMAN

NCBI Protein Information

cyclin-O; cyclin U; cyclin domain containing

NCBI Summary for CCNO

This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014]

UniProt Comments for CCNO

CCNO: This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 term is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes.[provided by RefSeq, Nov 2010]

Protein type: Cell cycle regulation; DNA repair, damage; EC 3.2.2.-; Hydrolase

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: uracil DNA N-glycosylase activity

Biological Process: response to drug; cell division; base-excision repair; cilium biogenesis; cell cycle

Disease: Ciliary Dyskinesia, Primary, 29

Research Articles on CCNO

1. CCNO mutations have a role in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCNO antibody

Reference Product	PubMed Publications
UNG antibody	>10 publications with CCNO and UNG
APEX1 antibody	>6 publications with CCNO and APEX1
PCNA antibody	>4 publications with CCNO and PCNA
APOBEC3G antibody	>2 publications with CCNO and APOBEC3G
XRCC1 antibody	>2 publications with CCNO and XRCC1
VPRBP antibody	>2 publications with CCNO and VPRBP
RPA2 antibody	>1 publications with CCNO and RPA2

Pathways associated with anti-CCNO antibody

Products by Pathway	Pathway Diagram
Base Excision Repair Pathway antibodies	Base Excision Repair Pathway Diagram
Base-Excision Repair, AP Site Formation Pathway antibodies	Base-Excision Repair, AP Site Formation Pathway Diagram
Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway antibodies	Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway Diagram
Cleavage Of The Damaged Pyrimidine Pathway antibodies	Cleavage Of The Damaged Pyrimidine Pathway Diagram
DNA Repair Pathway antibodies	DNA Repair Pathway Diagram
Depyrimidination Pathway antibodies	Depyrimidination Pathway Diagram
Displacement Of DNA Glycosylase By APE1 Pathway antibodies	Displacement Of DNA Glycosylase By APE1 Pathway Diagram
Recognition And Association Of DNA Glycosylase With Site Containing An Affected Pyrimidine Pathway antibodies	Recognition And Association Of DNA Glycosylase With Site Containing An Affected Pyrimidine Pathway Diagram
Removal Of DNA Patch Containing Abasic Residue Pathway antibodies	Removal Of DNA Patch Containing Abasic Residue Pathway Diagram
Resolution Of AP Sites Via The Multiple-nucleotide Patch Replacement Pathway antibodies	Resolution Of AP Sites Via The Multiple-nucleotide Patch Replacement Pathway Diagram

Diseases associated with anti-CCNO antibody

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>9 publications with CCNO and Immune System Diseases
Cardiovascular Diseases Antibodies	>1 publications with CCNO and Cardiovascular Diseases
Heart Diseases Antibodies	>1 publications with CCNO and Heart Diseases
Respiratory Tract Diseases Antibodies	>1 publications with CCNO and Respiratory Tract Diseases
Inflammation Antibodies	>1 publications with CCNO and Inflammation

Organs/Tissues associated with anti-CCNO antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>1 publications with CCNO and Kidney
Skin Antibodies	>1 publications with CCNO and Skin
Liver Antibodies	>1 publications with CCNO and Liver
Lung Antibodies	>1 publications with CCNO and Lung
Brain Antibodies	>1 publications with CCNO and Brain