• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

GPR48 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244683

MBS244683 is an antibody targeting GPR48. Also known as Rabbit Polyclonal to Human GPR48 / LGR4. Reactive in Gorilla, Human, OrangutanPredicted Reactivity: Monkey, Pig, Rabbit (at least 90% immunogen sequence identity). Host: Rabbit. GPR48 is an Orphan-A GPCR… More details

$650 / 0.05 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GPR48 / LGR4, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human GPR48 / LGR4
Product Gene Name
anti-GPR48 antibody
Product Synonym Gene Name
LGR4
Product Synonym Names
Anti-GPR48 / LGR4 Antibody (Cytoplasmic Domain) IHC-plus; LGR4; G-protein coupled receptor 48; G protein-coupled receptor 48; GPR48; Human GPR48; LGR4
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gorilla, Human, Orangutan
Predicted Reactivity: Monkey, Pig, Rabbit (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human LGR4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
101,667 Da
OMIM
gene 615311
3D Structure
ModBase 3D Structure for Q9BXB1
Target Species
Human
Immunogen Description
Synthetic 19 amino acid peptide from 2nd cytoplasmic domain of human LGR4. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Panda (100%); Monkey, Rabbit, Pig (95%); Gibbon, Dog, Bovine (89%); Marmoset, Bat (84%).
Immunogen Type
Synthetic peptide
Immunogen
GPR48 / LGR4 antibody was raised against synthetic 19 amino acid peptide from 2nd cytoplasmic domain of human LGR4. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Panda (100%); Monkey, Rabbit, Pig (95%); Gibbon, Dog, Bovine (89%); Marmoset, Bat (84%).
Antigen Modification
Cytoplasmic Domain

Product Categories/Family for anti-GPR48 antibody

Family: GPCR; Subfamily: Orphan-A
Applications Tested/Suitable for anti-GPR48 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-GPR48 antibody
IHC-P (4 - 10 ug/ml)

Immunohistochemistry (IHC) of anti-GPR48 antibody

Anti-LGR4 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GPR48 Polyclonal Antibody – Cat# MBS244683

Other Notes

Small volumes of anti-GPR48 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GPR48. It may not necessarily be applicable to this product.

NCBI GI #
157694513
NCBI GeneID
55366
NCBI Accession #
NP_060960.2
UniProt Primary Accession #
Q9BXB1
UniProt Secondary Accession #
Q8N537; Q9NYD1; A6NCH3; G5E9B3
UniProt Related Accession #
Q9BXB1
GenBank Nucleotide #
NM_018490.2
NCBI Official Full Name
leucine-rich repeat-containing G-protein coupled receptor 4
NCBI Official Synonym Full Names
leucine-rich repeat containing G protein-coupled receptor 4
NCBI Official Symbol
LGR4
NCBI Official Synonym Symbols
GPR48; BNMD17
UniProt Protein Name
Leucine-rich repeat-containing G-protein coupled receptor 4
UniProt Synonym Protein Names
G-protein coupled receptor 48
UniProt Gene Name
LGR4
UniProt Synonym Gene Names
GPR48
UniProt Entry Name
LGR4_HUMAN
NCBI Protein Information
leucine-rich repeat-containing G-protein coupled receptor 4; G protein-coupled receptor 48

NCBI Summary for GPR48

G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[supplied by OMIM, Aug 2008]

UniProt Comments for GPR48

LGR4: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. Plays an essential role during homeostasis of the adult mouse intestine.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11p14-p13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding; transmembrane receptor activity

Biological Process: osteoblast differentiation; G-protein coupled receptor protein signaling pathway; epithelial cell proliferation; positive regulation of transcription, DNA-dependent; negative regulation of cytokine secretion; male genitalia development; negative regulation of toll-like receptor signaling pathway; innate immune response; spermatogenesis; circadian regulation of gene expression; bone remodeling; negative regulation of transcription, DNA-dependent; bone mineralization

Disease: Bone Mineral Density Quantitative Trait Locus 17
Show more

Research Articles on GPR48

1. our results suggest a previously unknown Stat3-LGR4 molecular network, which may control osteosarcoma development and progression

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GPR48 antibody

 Reference Product  PubMed Publications
 ZNRF3 antibody  >9 publications with GPR48 and ZNRF3
 ATF4 antibody  >2 publications with GPR48 and ATF4
 PITX2 antibody  >2 publications with GPR48 and PITX2
 ESR1 antibody  >1 publications with GPR48 and ESR1

Pathways associated with anti-GPR48 antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies  RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By WNT In Cancer Pathway antibodies  Signaling By WNT In Cancer Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
 XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway antibodies  XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway Diagram
 Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway antibodies  Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway Diagram
 Regulation Of FZD By Ubiquitination Pathway antibodies  Regulation Of FZD By Ubiquitination Pathway Diagram

Diseases associated with anti-GPR48 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >4 publications with GPR48 and Kidney Diseases
 Infertility, Female Antibodies  >3 publications with GPR48 and Infertility, Female
 Inflammation Antibodies  >3 publications with GPR48 and Inflammation
 Neoplasms, Experimental Antibodies  >2 publications with GPR48 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >2 publications with GPR48 and Disease Models, Animal
 Liver Diseases Antibodies  >1 publications with GPR48 and Liver Diseases
 Abnormalities, Drug-Induced Antibodies  >1 publications with GPR48 and Abnormalities, Drug-Induced
 Necrosis Antibodies  >1 publications with GPR48 and Necrosis

Organs/Tissues associated with anti-GPR48 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >13 publications with GPR48 and Kidney
 Intestine Antibodies  >9 publications with GPR48 and Intestine
 Embryonic Tissue Antibodies  >8 publications with GPR48 and Embryonic Tissue
 Liver Antibodies  >7 publications with GPR48 and Liver
 Testis Antibodies  >7 publications with GPR48 and Testis
 Eye Antibodies  >7 publications with GPR48 and Eye
 Brain Antibodies  >7 publications with GPR48 and Brain
 Skin Antibodies  >6 publications with GPR48 and Skin
 Ovary Antibodies  >6 publications with GPR48 and Ovary
 Lung Antibodies  >4 publications with GPR48 and Lung
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000