KPI-2 Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]

Lmr2: a tyrosine kinase of the Lmr family that apparently phosphorylates Serine and Threonine residues. Associates with PP1C and Inh2 to form a regulatory complex that localizes to membranes. Enriched in brain and muscle. Inhibited in living cells by addition of nerve growth factor or serum. Appears to be inhibited by Cdk5/p35.

Protein type: Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, tyrosine (receptor); Protein kinase, TK; EC 2.7.11.1; TK group; Lmr family

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: Golgi apparatus; recycling endosome; perinuclear region of cytoplasm; early endosome; integral to membrane

Molecular Function: protein serine/threonine kinase activity; protein binding; protein phosphatase inhibitor activity; ATP binding

Biological Process: receptor recycling; peptidyl-serine phosphorylation; early endosome to late endosome transport; protein amino acid autophosphorylation; negative regulation of catalytic activity; peptidyl-threonine phosphorylation; transferrin transport; endocytic recycling; protein amino acid phosphorylation