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SLC1A5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244745

Solute Carrier Family 1 Member 5 (Slc1a5/ASCT2) belongs to a family of sodium dependent amino acid transporters. Slc1a5 has a preference for transporting zwitter ions. Slc1a5 also functions as a cell surface receptor for endogenously inherited retroviruses of… More details

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Product Overview

Online Datasheet in PDF
Product Name
SLC1A5 / ASCT2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human SLC1A5 / ASCT2
Product Gene Name
anti-SLC1A5 antibody
Product Synonym Gene Name
ASCT2
Product Synonym Names
Anti-SLC1A5 / ASCT2 Antibody (Internal) IHC-plus; SLC1A5; ATBO; ASCT2; ATB0; Baboon M7 virus receptor; AAAT; M7VS1; M7V1; R16; RDRC; RD114 virus receptor; RDR; ATB(0); Human SLC1A5; ASCT2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
0.3 mg/ml (lot specific)
Specificity
Human SLC1A5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
33,710 Da
OMIM
109190
3D Structure
ModBase 3D Structure for Q15758
Target Species
Human
Immunogen Description
Synthetic 17 amino acid peptide from internal region of human SLC1A5. Percent identity with other species by BLAST analysis: Human, Gibbon, Marmoset (100%); Monkey (94%); Dog, Horse (82%).
Immunogen Type
Synthetic peptide
Immunogen
SLC1A5 / ASCT2 antibody was raised against synthetic 17 amino acid peptide from internal region of human SLC1A5. Percent identity with other species by BLAST analysis: Human, Gibbon, Marmoset (100%); Monkey (94%); Dog, Horse (82%).
Antigen Modification
Internal

Product Categories/Family for anti-SLC1A5 antibody

Family: Transporter; Subfamily: Sodium:dicarboxylate symporter
Applications Tested/Suitable for anti-SLC1A5 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-SLC1A5 antibody
IHC-P (15 - 20 ug/ml)

Immunohistochemistry (IHC) of anti-SLC1A5 antibody

Anti-SLC1A5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-SLC1A5 Polyclonal Antibody – Cat# MBS244745

Immunohistochemistry (IHC) of anti-SLC1A5 antibody

Anti-SLC1A5 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-SLC1A5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244745

Other Notes

Small volumes of anti-SLC1A5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC1A5 purchase

MBS244745 is an antibody targeting SLC1A5. Also known as Rabbit Polyclonal to Human SLC1A5 / ASCT2. Reactive in Gibbon, Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC1A5. It may not necessarily be applicable to this product.

NCBI GI #
5032093
NCBI GeneID
6510
NCBI Accession #
NP_005619.1
UniProt Primary Accession #
Q15758
UniProt Secondary Accession #
O95720; Q96RL9; Q9BWQ3; Q9UNP2; A8K9H5; B4DR77; B4DWS4; B7ZB81; D0EYG6; E9PC01
UniProt Related Accession #
Q15758
GenBank Nucleotide #
NM_005628.2
NCBI Official Full Name
neutral amino acid transporter B(0) isoform 1
NCBI Official Synonym Full Names
solute carrier family 1 (neutral amino acid transporter), member 5
NCBI Official Symbol
SLC1A5
NCBI Official Synonym Symbols
R16; AAAT; ATBO; M7V1; RDRC; ASCT2; M7VS1
UniProt Protein Name
Neutral amino acid transporter B(0)
UniProt Synonym Protein Names
Baboon M7 virus receptor; RD114/simian type D retrovirus receptor; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5
Protein Family
Neutral amino acid transporter
UniProt Gene Name
SLC1A5
UniProt Synonym Gene Names
ASCT2; M7V1; RDR; RDRC; ATB(0)
UniProt Entry Name
AAAT_HUMAN
NCBI Protein Information
neutral amino acid transporter B(0); neutral amino acid transporter B(0); ATB(0); RD114 virus receptor; baboon M7 virus receptor; solute carrier family 1 member 5; RD114/simian type D retrovirus receptor; sodium-dependent neutral amino acid transporter type 2

NCBI Summary for SLC1A5

The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011]

UniProt Comments for SLC1A5

SLC1A5: Has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. Act as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses. Placenta, lung, skeletal muscle, kidney, pancreas, and intestine. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A5 subfamily. 1 isoforms of the human protein are produced by alternative initiation.

Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, SLC family

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: Golgi apparatus; membrane; integral to plasma membrane; melanosome; plasma membrane

Molecular Function: viral receptor activity; L-serine transmembrane transporter activity; protein binding; neutral amino acid transmembrane transporter activity; receptor activity; L-glutamine transmembrane transporter activity; sodium:dicarboxylate symporter activity

Biological Process: neutral amino acid transport; entry of virus into host cell; extracellular amino acid transport; dicarboxylic acid transport; amino acid transport; ion transport; glutamine transport; transmembrane transport; L-serine transport
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Research Articles on SLC1A5

1. the expression of LAT1 and ASCT2 is significantly increased in human melanoma. The importance of ASCT2 expression in melanoma was confirmed by shRNA knockdown, which inhibited glutamine uptake, mTORC1 signaling and cell proliferation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC1A5 antibody

 Reference Product  PubMed Publications
 SLC38A2 antibody  >7 publications with SLC1A5 and SLC38A2
 SLC6A19 antibody  >5 publications with SLC1A5 and SLC6A19
 ERVWE1 antibody  >2 publications with SLC1A5 and ERVWE1

Pathways associated with anti-SLC1A5 antibody

 Products by Pathway  Pathway Diagram
 Amino Acid Transport Across The Plasma Membrane Pathway antibodies  Amino Acid Transport Across The Plasma Membrane Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram

Diseases associated with anti-SLC1A5 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >16 publications with SLC1A5 and Adenocarcinoma
 Liver Neoplasms Antibodies  >8 publications with SLC1A5 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >7 publications with SLC1A5 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >7 publications with SLC1A5 and Liver Diseases
 Nervous System Diseases Antibodies  >7 publications with SLC1A5 and Nervous System Diseases
 Breast Neoplasms Antibodies  >5 publications with SLC1A5 and Breast Neoplasms
 Lung Diseases Antibodies  >5 publications with SLC1A5 and Lung Diseases
 Brain Diseases Antibodies  >5 publications with SLC1A5 and Brain Diseases
 Kidney Diseases Antibodies  >4 publications with SLC1A5 and Kidney Diseases
 Necrosis Antibodies  >4 publications with SLC1A5 and Necrosis

Organs/Tissues associated with anti-SLC1A5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >18 publications with SLC1A5 and Blood
 Intestine Antibodies  >17 publications with SLC1A5 and Intestine
 Brain Antibodies  >13 publications with SLC1A5 and Brain
 Placenta Antibodies  >12 publications with SLC1A5 and Placenta
 Kidney Antibodies  >11 publications with SLC1A5 and Kidney
 Liver Antibodies  >11 publications with SLC1A5 and Liver
 Eye Antibodies  >6 publications with SLC1A5 and Eye
 Lung Antibodies  >6 publications with SLC1A5 and Lung
 Embryonic Tissue Antibodies  >6 publications with SLC1A5 and Embryonic Tissue
 Muscle Antibodies  >5 publications with SLC1A5 and Muscle
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