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GPBAR1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244856

MBS244856 is an antibody targeting GPBAR1. Also known as Rabbit Polyclonal to Human GPBAR1 / TGR5. Reactive in Gorilla, HumanPredicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity). Host: Rabbit. BG37/TGR5 is the first Bile Acid GPCR… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
GPBAR1 / TGR5, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human GPBAR1 / TGR5
Product Gene Name
Product Synonym Gene Name
TGR5
Product Synonym Names
Anti-GPBAR1 / TGR5 Antibody (C-Terminus) IHC-plus; GPBAR1; BG37; GPR131; HGPCR19; M-BAR; GPCR19; TGR5; GPCR TGR5; HBG37; Membrane bile acid receptor; Human GPBAR1; TGR5
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gorilla, Human
Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human TGR5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
35,248 Da
OMIM
610147
3D Structure
ModBase 3D Structure for Q8TDU6
Target Species
Human
Immunogen Description
Synthetic 16 amino acid peptide from C-terminus of human TGR5. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey, Marmoset (94%).
Immunogen Type
Synthetic peptide
Immunogen
GPBAR1 / TGR5 antibody was raised against synthetic 16 amino acid peptide from C-terminus of human TGR5. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey, Marmoset (94%).
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-GPBAR1 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-GPBAR1 antibody
IHC-P (11 - 27 ug/ml)

Immunohistochemistry (IHC) of anti-GPBAR1 antibody

Anti-GPBAR1 / TGR5 antibody IHC of human colon, carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GPBAR1 Polyclonal Antibody – Cat# MBS244856

Immunohistochemistry (IHC) of anti-GPBAR1 antibody

Anti-TGR5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GPBAR1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244856

Immunohistochemistry (IHC) of anti-GPBAR1 antibody

Anti-GPBAR1 / TGR5 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GPBAR1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244856

Immunohistochemistry (IHC) of anti-GPBAR1 antibody

Anti-GPBAR1 / TGR5 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GPBAR1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244856

Immunohistochemistry (IHC) of anti-GPBAR1 antibody

Anti-GPBAR1 / TGR5 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GPBAR1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS244856

Other Notes

Small volumes of anti-GPBAR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GPBAR1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
G-protein coupled bile acid receptor 1
NCBI Official Synonym Full Names
G protein-coupled bile acid receptor 1
NCBI Official Symbol
GPBAR1
NCBI Official Synonym Symbols
BG37; TGR5; M-BAR; GPCR19; GPR131
UniProt Protein Name
G-protein coupled bile acid receptor 1
UniProt Synonym Protein Names
G-protein coupled receptor GPCR19; hGPCR19; Membrane-type receptor for bile acids; M-BAR; hBG37; BG37
UniProt Gene Name
GPBAR1
UniProt Synonym Gene Names
TGR5; hGPCR19; M-BAR; BG37
UniProt Entry Name
GPBAR_HUMAN
NCBI Protein Information
G-protein coupled bile acid receptor 1; hBG37; hGPCR19; membrane bile acid receptor; G-protein coupled receptor GPCR19; membrane-type receptor for bile acids; G-protein coupled bile acid receptor BG37

NCBI Summary for GPBAR1

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
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UniProt Comments for GPBAR1

GPBAR1: Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: cytoplasm; integral to membrane; plasma membrane

Biological Process: G-protein coupled receptor protein signaling pathway
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GPBAR1 antibody

 Reference Product  PubMed Publications
 GCG antibody  >2 publications with GPBAR1 and GCG
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