Rabbit Anti-FPR1 Polyclonal Antibody – Cat# MBS244883

Anti-FPR1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

FPR1 Antibody – Rabbit Polyclonal

Name: FPR1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS244883
Price: 650 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244883

Formyl peptide receptor 1, a Chemoattractant Receptor, mediates chemotaxis, degranulation, and superoxide production, as part of the inflammatory response. Bacterial N-formylmethionyl peptides and Annexin A1, specific ligands for FPR1, attract… More details

$650 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FPR1 / FPR, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human FPR1 / FPR

Product Gene Name

anti-FPR1 antibody

Product Synonym Gene Name

FPR

Product Synonym Names

Anti-FPR1 / FPR Antibody (Extracellular Domain) IHC-plus; FPR1; FPR-1; FMet-Leu-Phe receptor; FMLP; Formyl peptide receptor 1; FPR; N-formyl peptide receptor; FMLP receptor; Fpr receptor; N-formyl peptide receptor 1; Human FPR1; FPR

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Chimpanzee, Human, Monkey
Predicted Reactivity: Gorilla (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human FPR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

38,446 Da

OMIM

136537

3D Structure

ModBase 3D Structure for P21462

Target Species

Human

Immunogen Description

Synthetic 16 amino acid peptide from 3rd extracellular domain of human FPR1. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Monkey (100%); Gorilla (94%); Orangutan (88%).

Immunogen Type

Synthetic peptide

Immunogen

FPR1 / FPR antibody was raised against synthetic 16 amino acid peptide from 3rd extracellular domain of human FPR1. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Monkey (100%); Gorilla (94%); Orangutan (88%).

Antigen Modification

Extracellular Domain

Product Categories/Family for anti-FPR1 antibody

Family: GPCR; Subfamily: Chemoattractant

Applications Tested/Suitable for anti-FPR1 antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-FPR1 antibody

IHC-P (1 - 2 ug/ml)

Other Notes

Small volumes of anti-FPR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FPR1 purchase

MBS244883 is an antibody targeting FPR1. Also known as Rabbit Polyclonal to Human FPR1 / FPR. Reactive in Chimpanzee, Human, Monkey
Predicted Reactivity: Gorilla (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FPR1. It may not necessarily be applicable to this product.

NCBI GI #

4503779

NCBI GeneID

2357

NCBI Accession #

NP_002020.1

UniProt Primary Accession #

P21462

UniProt Secondary Accession #

Q14939; Q7Z6A4; Q86U52; Q9NS48

UniProt Related Accession #

P21462

GenBank Nucleotide #

NM_002029.3

NCBI Official Full Name

fMet-Leu-Phe receptor

NCBI Official Synonym Full Names

formyl peptide receptor 1

NCBI Official Symbol

FPR1

NCBI Official Synonym Symbols

FPR; FMLP

UniProt Protein Name

fMet-Leu-Phe receptor

UniProt Synonym Protein Names

N-formyl peptide receptor; FPR; N-formylpeptide chemoattractant receptor

Protein Family

FK506-binding protein

UniProt Gene Name

FPR1

UniProt Synonym Gene Names

fMLP receptor; FPR

UniProt Entry Name

FPR1_HUMAN

NCBI Protein Information

fMet-Leu-Phe receptor; fMLP receptor; N-formylpeptide chemoattractant receptor

NCBI Summary for FPR1

This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]

UniProt Comments for FPR1

FPR1: High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: plasma membrane; integral to membrane; endosome

Molecular Function: protein binding; RAGE receptor binding; N-formyl peptide receptor activity; receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; activation of MAPK activity; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); chemotaxis; signal transduction; cell motility; nitric oxide mediated signal transduction

Research Articles on FPR1

1. A low FPR1/beta1 integrin co-localization was observed.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FPR1 antibody

Reference Product	PubMed Publications
FPR2 antibody	>74 publications with FPR1 and FPR2
ANXA1 antibody	>14 publications with FPR1 and ANXA1
CXCR2 antibody	>5 publications with FPR1 and CXCR2
CCR1 antibody	>3 publications with FPR1 and CCR1
C3AR1 antibody	>1 publications with FPR1 and C3AR1
C5AR1 antibody	>1 publications with FPR1 and C5AR1

Pathways associated with anti-FPR1 antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway antibodies	Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies	Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-FPR1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>76 publications with FPR1 and Inflammation
Cardiovascular Diseases Antibodies	>8 publications with FPR1 and Cardiovascular Diseases
Necrosis Antibodies	>8 publications with FPR1 and Necrosis
Lung Diseases Antibodies	>6 publications with FPR1 and Lung Diseases
Vascular Diseases Antibodies	>6 publications with FPR1 and Vascular Diseases
Liver Diseases Antibodies	>6 publications with FPR1 and Liver Diseases
Heart Diseases Antibodies	>4 publications with FPR1 and Heart Diseases
Pain Antibodies	>3 publications with FPR1 and Pain
Asthma Antibodies	>3 publications with FPR1 and Asthma
Kidney Diseases Antibodies	>2 publications with FPR1 and Kidney Diseases

Organs/Tissues associated with anti-FPR1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>81 publications with FPR1 and Blood
Lung Antibodies	>12 publications with FPR1 and Lung
Brain Antibodies	>9 publications with FPR1 and Brain
Bone Marrow Antibodies	>9 publications with FPR1 and Bone Marrow
Intestine Antibodies	>7 publications with FPR1 and Intestine
Heart Antibodies	>6 publications with FPR1 and Heart
Kidney Antibodies	>5 publications with FPR1 and Kidney
Eye Antibodies	>5 publications with FPR1 and Eye
Stomach Antibodies	>3 publications with FPR1 and Stomach
Spleen Antibodies	>2 publications with FPR1 and Spleen