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DCN Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244947

MBS244947 is an antibody targeting DCN. Also known as Goat Polyclonal to Human DCN / Decorin. Reactive in Gibbon, Chimpanzee, Gorilla, Human, MonkeyPredicted Reactivity: Pig (at least 90% immunogen sequence identity). Host: Goat. More details

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Product Overview

Online Datasheet in PDF
Product Name
DCN / Decorin, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human DCN / Decorin
Product Gene Name
anti-DCN antibody
Product Synonym Names
Anti-DCN / Decorin Antibody (Internal) IHC-plus; DCN; CSCD; Decorin proteoglycan; PG-S2; PG40; Proteoglycan core protein; SLRR1B; Small leucine-rich protein 1B; PGII; PGS2; Bone proteoglycan II; Decorin; DSPG2; Human DCN; Decorin
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Chimpanzee, Gorilla, Human, Monkey
Predicted Reactivity: Pig (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human DCN / Decorin. This antibody is expected to recognize the three reported isoforms a, b and c (NP_001911.1; NP_598011.1; NP_598012.1 resp.). Reported variants NP_598010.1 and NP_001911.1 represent identical protein.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
8,266 Da
OMIM
gene 610048
3D Structure
ModBase 3D Structure for P07585
Target Species
Human
Immunogen Description
Synthetic peptide C-KISRVDAASLKGLNN from an internal region of human DCN / Decorin (NP_001911.1; NP_598011.1; NP_598012.1;).
Immunogen Type
Synthetic peptide
Immunogen
DCN / Decorin antibody was raised against synthetic peptide C-KISRVDAASLKGLNN from an internal region of human DCN / Decorin (NP_001911.1; NP_598011.1; NP_598012.1;). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey (100%); Pig (93%); Marmoset, Sheep, Goat, Bat, Bovine, Guinea pig (87%); Elephant, Dog, Horse (80%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-DCN antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-DCN antibody
ELISA (1:8000), IHC-P (3.75 ug/ml), WB (0.5 - 2 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:8000. Western blot: Approx 38kDa band observed in Human Kidney lysates (calculated MW of 39.7kDa according to NP_001911.1). Recommended concentration: 0.5-2 ug/ml.

Immunohistochemistry (IHC) of anti-DCN antibody

Anti-Decorin antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 3.75 ug/ml.
Goat Anti-DCN Polyclonal Antibody – Cat# MBS244947

Western Blot (WB) of anti-DCN antibody

DCN antibody (0.5 ug/ml) staining of Human Kidney lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-DCN Polyclonal Antibody, Western Blot (WB) – Cat# MBS244947

Other Notes

Small volumes of anti-DCN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DCN. It may not necessarily be applicable to this product.

NCBI GI #
4503271
NCBI GeneID
1634
NCBI Accession #
NP_001911.1
UniProt Primary Accession #
P07585
UniProt Secondary Accession #
Q9P0Z0; Q9P0Z1; Q9Y5N8; Q9Y5N9
UniProt Related Accession #
P07585
GenBank Nucleotide #
NM_001920.3
NCBI Official Full Name
decorin isoform a preproprotein
NCBI Official Synonym Full Names
decorin
NCBI Official Symbol
DCN
NCBI Official Synonym Symbols
CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B
UniProt Protein Name
Decorin
UniProt Synonym Protein Names
Bone proteoglycan II; PG-S2; PG40
Protein Family
Decorin
UniProt Gene Name
DCN
UniProt Synonym Gene Names
SLRR1B
UniProt Entry Name
PGS2_HUMAN
NCBI Protein Information
decorin; PG-S2; bone proteoglycan II; decorin proteoglycan; proteoglycan core protein; small leucine-rich protein 1B; dermatan sulphate proteoglycans II

NCBI Summary for DCN

The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq, Jul 2008]
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UniProt Comments for DCN

DCN: May affect the rate of fibrils formation. Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD). Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted; Extracellular matrix; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q21.33

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; lysosomal lumen; Golgi lumen; extracellular region; collagen type VI

Molecular Function: collagen binding; glycosaminoglycan binding; extracellular matrix binding; protein N-terminus binding

Biological Process: extracellular matrix organization and biogenesis; skeletal muscle development; chondroitin sulfate biosynthetic process; wound healing; glycosaminoglycan metabolic process; response to lipopolysaccharide; pathogenesis; dermatan sulfate biosynthetic process; chondroitin sulfate metabolic process; extracellular matrix disassembly; organ morphogenesis; response to mechanical stimulus; carbohydrate metabolic process; chondroitin sulfate catabolic process; kidney development; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; placenta development; aging

Disease: Corneal Dystrophy, Congenital Stromal
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Research Articles on DCN

1. AMPK is downstream of VEGFR2 and inhibition of AMPK signaling abrogated decorin-evoked autophagy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DCN antibody

 Reference Product  PubMed Publications
 TGFB1 antibody  >84 publications with DCN and TGFB1
 VCAN antibody  >71 publications with DCN and VCAN
 EGFR antibody  >20 publications with DCN and EGFR
 COL1A2 antibody  >7 publications with DCN and COL1A2
 THBS1 antibody  >6 publications with DCN and THBS1
 FN1 antibody  >5 publications with DCN and FN1
 DPT antibody  >4 publications with DCN and DPT
 FBN1 antibody  >4 publications with DCN and FBN1
 ELN antibody  >1 publications with DCN and ELN

Pathways associated with anti-DCN antibody

 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 CS/DS Degradation Pathway antibodies  CS/DS Degradation Pathway Diagram
 Chondroitin Sulfate Biosynthesis Pathway antibodies  Chondroitin Sulfate Biosynthesis Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway antibodies  Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective CHST14 Causes EDS, Musculocontractural Type Pathway antibodies  Defective CHST14 Causes EDS, Musculocontractural Type Pathway Diagram
 Defective CHST3 Causes SEDCJD Pathway antibodies  Defective CHST3 Causes SEDCJD Pathway Diagram
 Defective CHST6 Causes MCDC1 Pathway antibodies  Defective CHST6 Causes MCDC1 Pathway Diagram

Diseases associated with anti-DCN antibody

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >121 publications with DCN and Fibrosis
 Disease Models, Animal Antibodies  >98 publications with DCN and Disease Models, Animal
 Carcinoma Antibodies  >75 publications with DCN and Carcinoma
 Inflammation Antibodies  >56 publications with DCN and Inflammation
 Kidney Diseases Antibodies  >46 publications with DCN and Kidney Diseases
 Adenocarcinoma Antibodies  >27 publications with DCN and Adenocarcinoma
 Necrosis Antibodies  >24 publications with DCN and Necrosis
 Neoplasms, Experimental Antibodies  >24 publications with DCN and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >22 publications with DCN and Breast Neoplasms
 Liver Diseases Antibodies  >21 publications with DCN and Liver Diseases

Organs/Tissues associated with anti-DCN antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >699 publications with DCN and Brain
 Nerve Antibodies  >302 publications with DCN and Nerve
 Connective Tissue Antibodies  >168 publications with DCN and Connective Tissue
 Skin Antibodies  >163 publications with DCN and Skin
 Bone Antibodies  >155 publications with DCN and Bone
 Muscle Antibodies  >152 publications with DCN and Muscle
 Vascular Antibodies  >133 publications with DCN and Vascular
 Ear Antibodies  >90 publications with DCN and Ear
 Kidney Antibodies  >82 publications with DCN and Kidney
 Lung Antibodies  >66 publications with DCN and Lung
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