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FANCE Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS244989

MBS244989 is an antibody targeting FANCE. Also known as Goat Polyclonal to Human FANCE. Reactive in HumanPredicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity). Host: Goat. More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Product Overview

Product Name
FANCE, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human FANCE
Product Gene Name
Product Synonym Names
Anti-FANCE Antibody (Internal) IHC-plus; FANCE; FAE; Fanconi anemia group E protein; FACE; Protein FACE; Human FANCE
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human FANCE.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
58,711 Da
OMIM
phenotype 613976
3D Structure
ModBase 3D Structure for Q9HB96
Target Species
Human
Immunogen Description
Synthetic peptide C-EHKSLESLADGGS from an internal region of human FANCE (NP_068741.1). Percent identity with other species by BLAST analysis: Human (100%), Gibbon (92%), Monkey (92%), Marmoset (85%), Bovine (85%), Rabbit (85%).
Immunogen Type
Synthetic peptide
Immunogen
FANCE antibody was raised against synthetic peptide C-EHKSLESLADGGS from an internal region of human FANCE (NP_068741.1). Percent identity with other species by BLAST analysis: Human (100%), Gibbon (92%), Monkey (92%), Marmoset (85%), Bovine (85%), Rabbit (85%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-FANCE antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-FANCE antibody
ELISA (1:32000), IHC-P (3.75 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:32000. Western blot: Preliminary experiments gave an approx 70kD band in Human Adipose and Uterus lysates after 0.1 ug/ml antibody staining. Please note that currently we cannot find an explanation i...

Immunohistochemistry (IHC) of anti-FANCE antibody

Anti-FANCE antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-FANCE Polyclonal Antibody – Cat# MBS244989

Other Notes

Small volumes of anti-FANCE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FANCE. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
Fanconi anemia group E protein
NCBI Official Synonym Full Names
Fanconi anemia, complementation group E
NCBI Official Symbol
FANCE
NCBI Official Synonym Symbols
FAE; FACE
UniProt Protein Name
Fanconi anemia group E protein
UniProt Gene Name
FANCE
UniProt Synonym Gene Names
FACE; Protein FACE
UniProt Entry Name
FANCE_HUMAN
NCBI Protein Information
Fanconi anemia group E protein

NCBI Summary for FANCE

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E. [provided by RefSeq, Jul 2008]
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UniProt Comments for FANCE

FANCE: As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. Interacts with FANCC and FANCD2.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 6p22-p21

Cellular Component: nucleoplasm; nucleus

Biological Process: DNA repair

Disease: Fanconi Anemia, Complementation Group E; Tracheoesophageal Fistula With Or Without Esophageal Atresia
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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