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LAT2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS245126

MBS245126 is an antibody targeting LAT2. Also known as Mouse Monoclonal [clone NAP-03] (IgG2a) to Human LAT2 / NTAL. Reactive in Human. Host: Mouse. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
LAT2 / NTAL, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone NAP-03] (IgG2a) to Human LAT2 / NTAL
Product Gene Name
Product Synonym Gene Name
NTAL
Product Synonym Names
Anti-LAT2 / NTAL Antibody (aa196-212, clone NAP-03) IHC-plus; LAT2; HSPC046; Non-T-cell activation linker; NTAL; LAB; WBSCR15; WBS15; WBSCR5; WSCR5; Human LAT2; NTAL
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
NAP-03
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, 15 mM sodium azide, approx., pH 7.4.
Purity/Purification
Protein A Purified
Concentration
1 mg/ml (lot specific)
Specificity
Peptide corresponding to aa 196-212 of human NTAL coupled to KLH
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
12,255 Da
OMIM
605719
3D Structure
ModBase 3D Structure for Q9GZY6
Target Species
Human
Immunogen Description
Synthetic peptide from human LAT2.
Immunogen Type
Synthetic peptide
Immunogen
LAT2 / NTAL antibody was raised against synthetic peptide from human LAT2.
Antigen Modification
aa196-212
Applications Tested/Suitable for anti-LAT2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-LAT2 antibody
IHC-P (5 ug/ml), IP (1 - 2 ug/ml), WB (1 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-LAT2 antibody

Anti-LAT2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-LAT2 Monoclonal Antibody – Cat# MBS245126

Other Notes

Small volumes of anti-LAT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LAT2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
linker for activation of T-cells family member 2
NCBI Official Synonym Full Names
linker for activation of T cells family, member 2
NCBI Official Symbol
LAT2
NCBI Official Synonym Symbols
LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15
UniProt Protein Name
Linker for activation of T-cells family member 2
UniProt Synonym Protein Names
Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein
UniProt Gene Name
LAT2
UniProt Synonym Gene Names
LAB; NTAL; WBS15; WBSCR15; WBSCR5
UniProt Entry Name
NTAL_HUMAN
NCBI Protein Information
linker for activation of T-cells family member 2; non-T-cell activation linker; linker for activation of B-cells; membrane-associated adapter molecule; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosomal region 15 protein; linker for activation of T cells, transmembrane adaptor 2

NCBI Summary for LAT2

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]

UniProt Comments for LAT2

LAB: linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts.

Protein type: Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: mast cell granule; integral to membrane; plasma membrane; lipid raft

Molecular Function: protein binding; SH2 domain binding

Biological Process: B cell receptor signaling pathway; B cell activation; calcium-mediated signaling; innate immune response; mast cell degranulation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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