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PPM1G Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS245459

Protein Phosphatase PPM1G is a PP2C type serine/threonine phosphatase. Unlike other PP2C members, PPM1G contains a large acidic domain. Magnesium or manganese is required for its phosphorylation activity. PPM1G has been shown to physically associate with… More details

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Product Overview

Product Name
PPM1G, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone K1G6] (IgG1,k) to Human PPM1G
Product Gene Name
anti-PPM1G antibody
Product Synonym Names
Anti-PPM1G Antibody (aa317-546, clone K1G6) IHC-plus; PPM1G; Phosphatase fin13; PP2CG; PP2C-gamma; Protein phosphatase 1C; PP2C; gamma; PP2CGAMMA; PPM1C; PPP2CG; Protein phosphatase 2c gamma; Protein phosphatase 1G; Human PPM1G
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
K1G6
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.4, 0.1% sodium azide. Sourced in Ascites.
Purity/Purification
Protein G Purified
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.
Molecular Weight
59,272 Da
OMIM
605119
3D Structure
ModBase 3D Structure for O15355
Target Species
Human
Immunogen Description
Recombinant human PPM1G (317-546aa) purified from E Coli.
Immunogen Type
Recombinant protein
Immunogen
PPM1G antibody was raised against recombinant human PPM1G (317-546aa) purified from E Coli.
Antigen Modification
aa317-546

Product Categories/Family for anti-PPM1G antibody

Family: Protein Phosphatase; Subfamily: PP2C
Applications Tested/Suitable for anti-PPM1G antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-PPM1G antibody
ELISA, IHC-P (5 ug/ml), WB (1:1000 - 1:2000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-PPM1G antibody

Anti-PPM1G antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-PPM1G Monoclonal Antibody – Cat# MBS245459

Immunohistochemistry (IHC) of anti-PPM1G antibody

Anti-PPM1G antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-PPM1G Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS245459

Western Blot (WB) of anti-PPM1G antibody

Cell lysates of 293T (20 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human PPM1G (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
Mouse Anti-PPM1G Monoclonal Antibody, Western Blot (WB) – Cat# MBS245459

Other Notes

Small volumes of anti-PPM1G antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPM1G purchase

MBS245459 is an antibody targeting PPM1G. Also known as Mouse Monoclonal [clone K1G6] (IgG1,k) to Human PPM1G. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PPM1G. It may not necessarily be applicable to this product.

NCBI GI #
4505999
NCBI GeneID
5496
NCBI Accession #
NP_002698.1
UniProt Primary Accession #
O15355
UniProt Related Accession #
O15355
GenBank Nucleotide #
NM_002707.3
NCBI Official Synonym Full Names
protein phosphatase, Mg2+/Mn2+ dependent, 1G
NCBI Official Symbol
PPM1G
NCBI Official Synonym Symbols
PP2CG; PPP2CG; PP2CGAMMA
UniProt Protein Name
Protein phosphatase 1G
UniProt Synonym Protein Names
Protein phosphatase 1C; Protein phosphatase 2C isoform gamma; PP2C-gamma; Protein phosphatase magnesium-dependent 1 gamma
Protein Family
Protein phosphatase
UniProt Gene Name
PPM1G
UniProt Synonym Gene Names
PPM1C; PP2C-gamma
UniProt Entry Name
PPM1G_HUMAN
NCBI Protein Information
protein phosphatase 1G

NCBI Summary for PPM1G

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]
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UniProt Comments for PPM1G

PPM1G: is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]

Protein type: Spliceosome; Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding; metal ion binding; protein serine/threonine phosphatase activity

Biological Process: protein amino acid dephosphorylation; cell cycle arrest
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Research Articles on PPM1G

1. Hypermethylation in the 3'-protein-phosphatase-1G (PPM1G) gene locus was associated with alcohol use disorder.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PPM1G antibody

 Reference Product  PubMed Publications
 USP7 antibody  >1 publications with PPM1G and USP7

Pathways associated with anti-PPM1G antibody

 Products by Pathway  Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram

Diseases associated with anti-PPM1G antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1 publications with PPM1G and Necrosis

Organs/Tissues associated with anti-PPM1G antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >1 publications with PPM1G and Nerve
 Embryonic Tissue Antibodies  >1 publications with PPM1G and Embryonic Tissue
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