Mouse Anti-FAM175A Monoclonal Antibody – Cat# MBS245518

Anti-FAM175A / CCDC98 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

FAM175A Antibody – Mouse Monoclonal

Name: FAM175A Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS245518
Price: 650 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS245518

MBS245518 is an antibody targeting FAM175A. Also known as Mouse Monoclonal [clone ABRA1-01] (IgG) to Human FAM175A / CCDC98. Reactive in Human. Host: Mouse. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

FAM175A / CCDC98, Monoclonal Antibody

Full Product Name

Mouse Monoclonal [clone ABRA1-01] (IgG) to Human FAM175A / CCDC98

Product Gene Name

anti-FAM175A antibody

Product Synonym Gene Name

CCDC98

Product Synonym Names

Anti-FAM175A / CCDC98 Antibody (clone ABRA1-01) IHC-plus; FAM175A; Abraxas protein; ABRAXAS; CCDC98; ABRA1; Protein FAM175A; Human FAM175A; CCDC98

Clonality

Monoclonal

Isotype

IgG

Clone Number

ABRA1-01

Host

Mouse

Species Reactivity

Human

Form/Format

PBS, 15 mM sodium azide, pH 7.4. Sourced in Ascites.

Purity/Purification

Protein A Purified

Concentration

1 mg/ml (lot specific)

Specificity

The mouse monoclonal antibody ABRA1-01 recognizes N-terminal part of ABRA1 (Abraxas, CCDC98), an adaptor protein involved in DNA repair, which migrates as a 45 kD band on PAAGE under reducing conditions.

Preparation and Storage

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Molecular Weight

46,663 Da

OMIM

phenotype 611143

3D Structure

ModBase 3D Structure for Q6UWZ7

Target Species

Human

Immunogen Description

Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag.

Immunogen Type

Recombinant protein

Immunogen

FAM175A / CCDC98 antibody was raised against recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag.

Applications Tested/Suitable for anti-FAM175A antibody

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)

Application Notes for anti-FAM175A antibody

Flo (1 - 2 ug/ml), IHC-P (10 ug/ml), IP, WB
Usage: Flow Cytometry. Recommended dilution:1-2 ug/ml. Immunoprecipitation. Western Blotting. Application note: reducing conditions.

Other Notes

Small volumes of anti-FAM175A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FAM175A. It may not necessarily be applicable to this product.

NCBI GI #

109148531

NCBI GeneID

84142

NCBI Accession #

NP_620775.2

UniProt Primary Accession #

Q6UWZ7

UniProt Secondary Accession #

Q9H8I1; Q9H9N4; A5JJ07

UniProt Related Accession #

Q6UWZ7

GenBank Nucleotide #

NM_139076.2

NCBI Official Full Name

BRCA1-A complex subunit Abraxas

NCBI Official Synonym Full Names

family with sequence similarity 175, member A

NCBI Official Symbol

FAM175A

NCBI Official Synonym Symbols

ABRA1; CCDC98

UniProt Protein Name

BRCA1-A complex subunit Abraxas

UniProt Synonym Protein Names

Coiled-coil domain-containing protein 98; Protein FAM175A

Protein Family

BRCA1-A complex

UniProt Gene Name

FAM175A

UniProt Synonym Gene Names

ABRA1; CCDC98

UniProt Entry Name

F175A_HUMAN

NCBI Protein Information

BRCA1-A complex subunit Abraxas; abraxas protein; coiled-coil domain containing 98; coiled-coil domain-containing protein 98

UniProt Comments for FAM175A

Abraxas: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1. Belongs to the FAM175 family. Abraxas subfamily.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 4q21.23

Cellular Component: nucleus

Molecular Function: protein binding; polyubiquitin binding

Biological Process: positive regulation of DNA repair; double-strand break repair; chromatin modification; response to ionizing radiation; G2/M transition DNA damage checkpoint

Research Articles on FAM175A

1. The recurrent Abraxas c.1082G>A mutation connects to breast cancer predisposition.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FAM175A antibody

Reference Product	PubMed Publications
BRCA1 antibody	>23 publications with FAM175A and BRCA1
BRCC3 antibody	>6 publications with FAM175A and BRCC3
BRE antibody	>4 publications with FAM175A and BRE
BARD1 antibody	>3 publications with FAM175A and BARD1
ATM antibody	>2 publications with FAM175A and ATM
MRE11A antibody	>2 publications with FAM175A and MRE11A
RAD50 antibody	>1 publications with FAM175A and RAD50
UIMC1 antibody	>1 publications with FAM175A and UIMC1

Diseases associated with anti-FAM175A antibody

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>7 publications with FAM175A and Breast Neoplasms
Ovarian Neoplasms Antibodies	>5 publications with FAM175A and Ovarian Neoplasms

Organs/Tissues associated with anti-FAM175A antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>2 publications with FAM175A and Lung