PAWR Antibody – Mouse Monoclonal

The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008]

PAR-4: a proapoptotic protein that drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappaB transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 12q21

Cellular Component: cytoplasm; plasma membrane; actin filament; nucleus; actin cytoskeleton

Molecular Function: protein binding; leucine zipper domain binding; enzyme binding; actin binding; transcription corepressor activity

Biological Process: actin filament bundle formation; negative regulation of cell proliferation; negative regulation of T cell proliferation; interleukin-2 biosynthetic process; transcription, DNA-dependent; positive regulation of apoptosis; apoptosis; negative regulation of T cell receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of B cell proliferation; positive regulation of amyloid precursor protein biosynthetic process