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CLIC1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS245621

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CLIC1 / NCC27, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 2D4] (IgG1,k) to Human CLIC1 / NCC27
Product Gene Name
anti-CLIC1 antibody
Product Synonym Gene Name
NCC27
Product Synonym Names
Anti-CLIC1 / NCC27 Antibody (clone 2D4) IHC-plus; CLIC1; Chloride channel ABP; G6; Nuclear chloride channel-27; p64CLCP; RNCC protein; HRNCC; NCC27; Human CLIC1; NCC27
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
2D4
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.2. Sourced in Ascites.
Purity/Purification
Protein A Purified
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
Molecular Weight
26,923 Da
OMIM
602872
3D Structure
ModBase 3D Structure for O00299
Target Species
Human
Immunogen Description
CLIC1 (AAH64527, 1 a.a. ~ 242 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen Type
Recombinant protein
Immunogen
CLIC1 / NCC27 antibody was raised against cLIC1 (AAH64527, 1 a.a. ~ 242 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Product Categories/Family for anti-CLIC1 antibody

Family: Ion Channel; Subfamily: Chloride channel - intracellular
Applications Tested/Suitable for anti-CLIC1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-CLIC1 antibody
ELISA, IHC-P (2.5 ug/ml), WB
Usage: Western Blot (Cell lysate) - positive control HL-60.

Immunohistochemistry (IHC) of anti-CLIC1 antibody

Anti-CLIC1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Mouse Anti-CLIC1 Monoclonal Antibody – Cat# MBS245621

Immunohistochemistry (IHC) of anti-CLIC1 antibody

Anti-CLIC1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Mouse Anti-CLIC1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS245621

Western Blot (WB) of anti-CLIC1 antibody

CLIC1 monoclonal antibody, clone 2D4 Western blot of CLIC1 expression in HL-60.
Mouse Anti-CLIC1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS245621

Other Notes

Small volumes of anti-CLIC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLIC1 purchase

MBS245621 is an antibody targeting CLIC1. Also known as Mouse Monoclonal [clone 2D4] (IgG1,k) to Human CLIC1 / NCC27. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CLIC1. It may not necessarily be applicable to this product.

NCBI GI #
14251209
NCBI GeneID
1192
NCBI Accession #
NP_001279.2
UniProt Primary Accession #
O00299
UniProt Secondary Accession #
Q15089; Q502X1
UniProt Related Accession #
O00299
GenBank Nucleotide #
NM_001288.4
NCBI Official Full Name
chloride intracellular channel protein 1
NCBI Official Synonym Full Names
chloride intracellular channel 1
NCBI Official Symbol
CLIC1
NCBI Official Synonym Symbols
G6; NCC27
UniProt Protein Name
Chloride intracellular channel protein 1
UniProt Synonym Protein Names
Chloride channel ABP; Nuclear chloride ion channel 27; NCC27; Regulatory nuclear chloride ion channel protein; hRNCC
Protein Family
Chloride intracellular channel protein
UniProt Gene Name
CLIC1
UniProt Synonym Gene Names
G6; NCC27; NCC27; hRNCC
UniProt Entry Name
CLIC1_HUMAN
NCBI Protein Information
chloride intracellular channel protein 1; hRNCC; p64CLCP; RNCC protein; chloride channel ABP; nuclear chloride ion channel 27; nuclear chloride ion channel protein; regulatory nuclear chloride ion channel protein

UniProt Comments for CLIC1

CLIC1: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. Belongs to the chloride channel CLIC family.

Protein type: Channel, chloride; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: extracellular space; nuclear membrane; membrane; mitochondrion; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nuclear envelope; nucleus; brush border; vesicle

Molecular Function: protein binding; chloride channel activity; voltage-gated ion channel activity

Biological Process: positive regulation of osteoblast differentiation; regulation of mitochondrial membrane potential; regulation of cell cycle; chloride transport; signal transduction
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Research Articles on CLIC1

1. Mutation of the two charged amino acids (K37 and R29) in the putative transmembrane region of CLIC1 alters the biophysical properties of the ion channel in both artificial bilayers and cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CLIC1 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >8 publications with CLIC1 and Liver Diseases
 Nervous System Diseases Antibodies  >8 publications with CLIC1 and Nervous System Diseases
 Brain Diseases Antibodies  >7 publications with CLIC1 and Brain Diseases
 Neoplasm Metastasis Antibodies  >7 publications with CLIC1 and Neoplasm Metastasis
 Carcinoma, Hepatocellular Antibodies  >6 publications with CLIC1 and Carcinoma, Hepatocellular
 Necrosis Antibodies  >5 publications with CLIC1 and Necrosis
 Inflammation Antibodies  >4 publications with CLIC1 and Inflammation
 Cardiovascular Diseases Antibodies  >2 publications with CLIC1 and Cardiovascular Diseases
 Hemorrhage Antibodies  >1 publications with CLIC1 and Hemorrhage
 Anemia Antibodies  >1 publications with CLIC1 and Anemia

Organs/Tissues associated with anti-CLIC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with CLIC1 and Blood
 Brain Antibodies  >9 publications with CLIC1 and Brain
 Liver Antibodies  >8 publications with CLIC1 and Liver
 Muscle Antibodies  >6 publications with CLIC1 and Muscle
 Bone Antibodies  >6 publications with CLIC1 and Bone
 Kidney Antibodies  >6 publications with CLIC1 and Kidney
 Stomach Antibodies  >4 publications with CLIC1 and Stomach
 Lymph Antibodies  >3 publications with CLIC1 and Lymph
 Vascular Antibodies  >3 publications with CLIC1 and Vascular
 Lymph Node Antibodies  >3 publications with CLIC1 and Lymph Node
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