Mouse Anti-SELPLG Monoclonal Antibody – Cat# MBS245632

Anti-SELPLG / CD162 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

SELPLG Antibody – Mouse Monoclonal

Name: SELPLG Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS245632
Price: 650 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS245632

SELPLG is the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. The organization of the… More details

$650 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SELPLG / PSGL-1 / CD162, Monoclonal Antibody

Full Product Name

Mouse Monoclonal [clone TC2] (IgG1) to Human SELPLG / PSGL-1 / CD162

Product Gene Name

anti-SELPLG antibody

Product Synonym Gene Name

PSGL-1; CD162

Product Synonym Names

Anti-SELPLG / PSGL-1 / CD162 Antibody (clone TC2) IHC-plus; SELPLG; CD162 antigen; CLA; CD162; PSGL1; PSGL-1; Selectin P ligand; Human SELPLG; PSGL-1; CD162

Clonality

Monoclonal

Isotype

IgG1

Clone Number

TC2

Host

Mouse

Species Reactivity

Human

Form/Format

PBS, 15 mM sodium azide, pH 7.4

Purity/Purification

Protein A Purified

Concentration

1 mg/ml (lot specific)

Specificity

The antibody TC2 reacts with CD162, a 220 kD type I integral membrane protein expressed as disulfide-linked homodimer (sialomucin family). CD162 is present on the most peripheral blood T lymphocytes, monocytes, granulocytes; it is also expressed on a subpopulation of B lymphocytes and CD34+ bone marrow cells.

Preparation and Storage

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Molecular Weight

44,648 Da

OMIM

600738

3D Structure

ModBase 3D Structure for Q14242

Target Species

Human

Applications Tested/Suitable for anti-SELPLG antibody

Immunohistochemistry (IHC - Paraffin), Flow Cytometry (FC/FACS)

Application Notes for anti-SELPLG antibody

Flo (1.5 - 2.5 ug/ml), IHC-P (10 ug/ml)
Usage: Flow Cytometry. Recommended dilution:1.5 - 2.5 ug/ml. Positive control:human peripheral blood.

Other Notes

Small volumes of anti-SELPLG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SELPLG purchase

MBS245632 is an antibody targeting SELPLG. Also known as Mouse Monoclonal [clone TC2] (IgG1) to Human SELPLG / PSGL-1 / CD162. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for SELPLG. It may not necessarily be applicable to this product.

NCBI GI #

4506879

NCBI GeneID

6404

NCBI Accession #

NP_002997.1

UniProt Primary Accession #

Q14242

UniProt Secondary Accession #

Q12775; Q6GTW7; Q8N7J7; A8K2Y0; B4DQC3; B7Z5C7; J3KMX6

UniProt Related Accession #

Q14242

GenBank Nucleotide #

NM_003006.3

NCBI Official Full Name

P-selectin glycoprotein ligand 1

NCBI Official Synonym Full Names

selectin P ligand

NCBI Official Symbol

SELPLG

NCBI Official Synonym Symbols

CLA; CD162; PSGL1; PSGL-1

UniProt Protein Name

P-selectin glycoprotein ligand 1

UniProt Synonym Protein Names

Selectin P ligand; CD_antigen: CD162

Protein Family

P-selectin glycoprotein ligand

UniProt Gene Name

SELPLG

UniProt Synonym Gene Names

PSGL-1

UniProt Entry Name

SELPL_HUMAN

NCBI Protein Information

P-selectin glycoprotein ligand 1; cutaneous lymphocyte-associated associated antigen

NCBI Summary for SELPLG

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

UniProt Comments for SELPLG

SELPLG: A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: membrane; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; receptor binding

Biological Process: leukocyte tethering or rolling; cell adhesion; blood coagulation; leukocyte migration; leukocyte adhesive activation

Research Articles on SELPLG

1. Up-regulation of PSGL-1 on CD14++CD16+ monocytes may play a crucial role in plaque rupture and thrombus formation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SELPLG antibody

Reference Product	PubMed Publications
SELP antibody	>6 publications with SELPLG and SELP
SYK antibody	>1 publications with SELPLG and SYK
SELL antibody	>1 publications with SELPLG and SELL

Pathways associated with anti-SELPLG antibody

Products by Pathway	Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Staphylococcus Aureus Infection Pathway antibodies	Staphylococcus Aureus Infection Pathway Diagram
Staphylococcus Aureus Infection Pathway antibodies	Staphylococcus Aureus Infection Pathway Diagram
Amb2 Integrin Signaling Pathway antibodies	Amb2 Integrin Signaling Pathway Diagram

Diseases associated with anti-SELPLG antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>7 publications with SELPLG and Cardiovascular Diseases
Heart Diseases Antibodies	>4 publications with SELPLG and Heart Diseases
Atherosclerosis Antibodies	>4 publications with SELPLG and Atherosclerosis
Inflammation Antibodies	>2 publications with SELPLG and Inflammation
Hypertension Antibodies	>1 publications with SELPLG and Hypertension
Diabetes Mellitus, Type 2 Antibodies	>1 publications with SELPLG and Diabetes Mellitus, Type 2
Neurobehavioral Manifestations Antibodies	>1 publications with SELPLG and Neurobehavioral Manifestations
Myocardial Infarction Antibodies	>1 publications with SELPLG and Myocardial Infarction
Neoplasms, Experimental Antibodies	>1 publications with SELPLG and Neoplasms, Experimental
Necrosis Antibodies	>1 publications with SELPLG and Necrosis

Organs/Tissues associated with anti-SELPLG antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>11 publications with SELPLG and Blood
Bone Antibodies	>2 publications with SELPLG and Bone
Heart Antibodies	>2 publications with SELPLG and Heart
Bone Marrow Antibodies	>2 publications with SELPLG and Bone Marrow
Placenta Antibodies	>2 publications with SELPLG and Placenta
Embryonic Tissue Antibodies	>2 publications with SELPLG and Embryonic Tissue
Lung Antibodies	>1 publications with SELPLG and Lung
Spleen Antibodies	>1 publications with SELPLG and Spleen
Brain Antibodies	>1 publications with SELPLG and Brain