CAPZ Antibody – Mouse Monoclonal

This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]

CAPZB: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Belongs to the F-actin-capping protein beta subunit family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1p36.1

Cellular Component: F-actin capping protein complex; sarcomere; cytoskeleton; actin filament; cytosol; actin cytoskeleton

Molecular Function: actin filament binding; actin binding

Biological Process: regulation of cell morphogenesis; cytoskeleton organization and biogenesis; barbed-end actin filament capping; cell motility; actin cytoskeleton organization and biogenesis; blood coagulation; negative regulation of filopodium formation