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SNRPA Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS245881

MBS245881 is an antibody targeting SNRPA. Also known as Mouse Monoclonal [clone 3F9-1F7] (IgG1,k) to Human SNRPA / U1A. Reactive in Human. Host: Mouse. More details

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Product Overview

Product Name
SNRPA / U1A, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 3F9-1F7] (IgG1,k) to Human SNRPA / U1A
Product Gene Name
anti-SNRPA antibody
Product Synonym Gene Name
U1A
Product Synonym Names
Anti-SNRPA / U1A Antibody (clone 3F9-1F7) IHC-plus; SNRPA; U1A; Mud1; U1 snRNP A; U1 snRNP-specific protein A; U1-A; Human SNRPA; U1A
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
3F9-1F7
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.2. Sourced in Ascites.
Purity/Purification
Protein A Purified
Concentration
0.4 mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
Molecular Weight
31,280 Da
OMIM
182285
3D Structure
ModBase 3D Structure for P09012
Target Species
Human
Immunogen Description
SNRPA (AAH00405, 1 a.a. ~ 283 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen Type
Recombinant protein
Immunogen
SNRPA / U1A antibody was raised against sNRPA (AAH00405, 1 a.a. ~ 283 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Applications Tested/Suitable for anti-SNRPA antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-SNRPA antibody
ELISA, IF (10 ug/ml), IHC-P (5 ug/ml), WB
Usage: Western Blot (Cell lysate) - positive control Hela. Western Blot (Transfected lysate) - positive control transfected 293T cell line. Immunofluorescence (10 ug/ml) - positive control HeLa cells. Sandwich ELISA (Recombinant protein).

Immunohistochemistry (IHC) of anti-SNRPA antibody

Anti-SNRPA antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-SNRPA Monoclonal Antibody – Cat# MBS245881

Immunohistochemistry (IHC) of anti-SNRPA antibody

Anti-SNRPA antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-SNRPA Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS245881

Immunohistochemistry (IHC) of anti-SNRPA antibody

Anti-SNRPA antibody IHC of human small intestine, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-SNRPA Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS245881

Immunofluorescence (IF) of anti-SNRPA antibody

Immunofluorescence of monoclonal antibody to SNRPA on HeLa cell (antibody concentration 10 ug/ml).
Mouse Anti-SNRPA Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS245881

Western Blot (WB) of anti-SNRPA antibody

Western blot of SNRPA expression in transfected 293T cell line by SNRPA monoclonal antibody clone 3F9-1F7.
Mouse Anti-SNRPA Monoclonal Antibody, Western Blot (WB) – Cat# MBS245881

Western Blot (WB) of anti-SNRPA antibody

SNRPA monoclonal antibody (M01), clone 3F9-1F7 Western blot of SNRPA expression in HeLa.
Mouse Anti-SNRPA Monoclonal Antibody, Western Blot (WB) – Cat# MBS245881

ELISA (EIA) of anti-SNRPA antibody

Detection limit for recombinant GST tagged SNRPA is approximately 0.03 ng/ml as a capture antibody.
Mouse Anti-SNRPA Monoclonal Antibody, ELISA (EIA) – Cat# MBS245881

Other Notes

Small volumes of anti-SNRPA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SNRPA. It may not necessarily be applicable to this product.

NCBI GI #
4759156
NCBI GeneID
6626
NCBI Accession #
NP_004587.1
UniProt Primary Accession #
P09012
UniProt Related Accession #
P09012
GenBank Nucleotide #
NM_004596.4
NCBI Official Full Name
U1 small nuclear ribonucleoprotein A
NCBI Official Synonym Full Names
small nuclear ribonucleoprotein polypeptide A
NCBI Official Symbol
SNRPA
NCBI Official Synonym Symbols
U1A; Mud1; U1-A
UniProt Protein Name
U1 small nuclear ribonucleoprotein A
Protein Family
U1 small nuclear ribonucleoprotein
UniProt Gene Name
SNRPA
UniProt Synonym Gene Names
U1 snRNP A; U1-A; U1A
UniProt Entry Name
SNRPA_HUMAN
NCBI Protein Information
U1 small nuclear ribonucleoprotein A; U1 snRNP A; U1 snRNP-specific protein A; U1 small nuclear RNP-specific A

NCBI Summary for SNRPA

The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]
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UniProt Comments for SNRPA

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.
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Research Articles on SNRPA

1. a new mechanism for regulating SMN levels and provides new insight into the roles of U1A in 3' processing of mRNAs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SNRPA antibody

 Reference Product  PubMed Publications
 SNRNP70 antibody  >1 publications with SNRPA and SNRNP70
 U2AF2 antibody  >1 publications with SNRPA and U2AF2

Pathways associated with anti-SNRPA antibody

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome, U1-snRNP Pathway antibodies  Spliceosome, U1-snRNP Pathway Diagram
 Spliceosome, U1-snRNP Pathway antibodies  Spliceosome, U1-snRNP Pathway Diagram
 MRNA Splicing Pathway antibodies  MRNA Splicing Pathway Diagram
 MRNA Splicing - Major Pathway antibodies  MRNA Splicing - Major Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram

Diseases associated with anti-SNRPA antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >1 publications with SNRPA and Adenocarcinoma
 Prostatic Diseases Antibodies  >1 publications with SNRPA and Prostatic Diseases
 Breast Neoplasms Antibodies  >1 publications with SNRPA and Breast Neoplasms
 Liver Diseases Antibodies  >1 publications with SNRPA and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with SNRPA and Liver Neoplasms

Organs/Tissues associated with anti-SNRPA antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with SNRPA and Muscle
 Liver Antibodies  >2 publications with SNRPA and Liver
 Spleen Antibodies  >1 publications with SNRPA and Spleen
 Connective Tissue Antibodies  >1 publications with SNRPA and Connective Tissue
 Kidney Antibodies  >1 publications with SNRPA and Kidney
 Prostate Antibodies  >1 publications with SNRPA and Prostate
 Intestine Antibodies  >1 publications with SNRPA and Intestine
 Lung Antibodies  >1 publications with SNRPA and Lung
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