• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

MTDH Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS245974

MBS245974 is an antibody targeting MTDH. Also known as Mouse Monoclonal [clone 2F11C3] (IgG1) to Human MTDH / Metadherin. Reactive in Human. Host: Mouse. More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
MTDH / Metadherin, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 2F11C3] (IgG1) to Human MTDH / Metadherin
Product Gene Name
anti-MTDH antibody
Product Synonym Names
Anti-MTDH / Metadherin Antibody (clone 2F11C3) IHC-plus; MTDH; 3D3; AEG1; AEG-1; Metadherin; LYRIC; Metastasis adhesion protein; Protein LYRIC; Human MTDH; Metadherin
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2F11C3
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid in PBS, 50% glycerol, 0.03% sodium azide
Purity/Purification
Protein G Purified
Specificity
Human MTDH
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
Molecular Weight
63,837 Da
OMIM
610323
3D Structure
ModBase 3D Structure for Q86UE4
Target Species
Human
Immunogen Description
Purified recombinant fragment of human MTDH expressed in E Coli.
Immunogen
MTDH / Metadherin antibody was raised against purified recombinant fragment of human MTDH expressed in E Coli.
Applications Tested/Suitable for anti-MTDH antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Flow Cytometry (FC/FACS), ELISA (EIA)
Application Notes for anti-MTDH antibody
ELISA (1:10000), Flo (1:200 - 1:400), IHC-P (1:200), WB (1:500 - 1:2000)

Immunohistochemistry (IHC) of anti-MTDH antibody

Anti-MTDH antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Mouse Anti-MTDH Monoclonal Antibody – Cat# MBS245974

Immunohistochemistry (IHC) of anti-MTDH antibody

Anti-MTDH antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Mouse Anti-MTDH Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS245974

Flow Cytometry (FC/FACS) of anti-MTDH antibody

Flow cytometry of HeLa cells using anti-Metadherin mAb (green) and negative control (purple).
Mouse Anti-MTDH Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS245974

Western Blot (WB) of anti-MTDH antibody

Western blot of anti-Metadherin mAb against K562 (1), SKBR-3 (2), T47D (3), HeLa (4) and MCF-7 (5) cell lysate.
Mouse Anti-MTDH Monoclonal Antibody, Western Blot (WB) – Cat# MBS245974

Other Notes

Small volumes of anti-MTDH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MTDH. It may not necessarily be applicable to this product.

NCBI GI #
223555917
NCBI GeneID
92140
NCBI Accession #
NP_848927.2
UniProt Primary Accession #
Q86UE4
UniProt Secondary Accession #
Q05DH2; Q52QU9; Q6PK07; Q8TCX3
UniProt Related Accession #
Q86UE4
GenBank Nucleotide #
NM_178812.3
NCBI Official Full Name
protein LYRIC
NCBI Official Synonym Full Names
metadherin
NCBI Official Symbol
MTDH
NCBI Official Synonym Symbols
3D3; AEG1; AEG-1; LYRIC; LYRIC/3D3
UniProt Protein Name
Protein LYRIC
UniProt Synonym Protein Names
3D3/LYRIC; Astrocyte elevated gene-1 protein; AEG-1; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein
Protein Family
Protein LYRIC
UniProt Gene Name
MTDH
UniProt Synonym Gene Names
AEG1; LYRIC; AEG-1
UniProt Entry Name
LYRIC_HUMAN
NCBI Protein Information
protein LYRIC; 3D3/LYRIC; astrocyte elevated gene 1; metastasis adhesion protein; astrocyte elevated gene-1 protein; lysine-rich CEACAM1 co-isolated protein

UniProt Comments for MTDH

Lyric: a protein of unknown function.

Protein type: Nucleolus; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: nuclear body; intercellular canaliculus; endoplasmic reticulum membrane; nuclear membrane; tight junction; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; apical plasma membrane; integral to membrane; nucleolus; nucleus

Molecular Function: NF-kappaB binding; protein binding; double-stranded RNA binding; transcription coactivator activity

Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; lipopolysaccharide-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of autophagy; activation of NF-kappaB transcription factor; negative regulation of apoptosis
Show more

Research Articles on MTDH

1. HBx could elevate AEG-1 protein level without altering its mRNA level. When blocking AEG-1 expression with siRNA in HBx-transfected cells, the HBx-induced cell migration was significantly suppressed.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MTDH antibody

 Reference Product  PubMed Publications
 MYC antibody  >18 publications with MTDH and MYC
 CRISP1 antibody  >1 publications with MTDH and CRISP1
 TFCP2 antibody  >1 publications with MTDH and TFCP2
 DPYD antibody  >1 publications with MTDH and DPYD
 MAX antibody  >1 publications with MTDH and MAX

Pathways associated with anti-MTDH antibody

 Products by Pathway  Pathway Diagram
 Gastric Cancer Network 2 Pathway antibodies  Gastric Cancer Network 2 Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram

Diseases associated with anti-MTDH antibody

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >49 publications with MTDH and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >40 publications with MTDH and Breast Neoplasms
 Liver Neoplasms Antibodies  >30 publications with MTDH and Liver Neoplasms
 Liver Diseases Antibodies  >27 publications with MTDH and Liver Diseases
 Brain Diseases Antibodies  >16 publications with MTDH and Brain Diseases
 Central Nervous System Diseases Antibodies  >14 publications with MTDH and Central Nervous System Diseases
 Nervous System Diseases Antibodies  >14 publications with MTDH and Nervous System Diseases
 Death Antibodies  >13 publications with MTDH and Death
 Necrosis Antibodies  >11 publications with MTDH and Necrosis
 Disease Models, Animal Antibodies  >9 publications with MTDH and Disease Models, Animal

Organs/Tissues associated with anti-MTDH antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >33 publications with MTDH and Liver
 Lymph Antibodies  >25 publications with MTDH and Lymph
 Lymph Node Antibodies  >23 publications with MTDH and Lymph Node
 Lung Antibodies  >22 publications with MTDH and Lung
 Brain Antibodies  >16 publications with MTDH and Brain
 Prostate Antibodies  >15 publications with MTDH and Prostate
 Blood Antibodies  >11 publications with MTDH and Blood
 Vascular Antibodies  >10 publications with MTDH and Vascular
 Kidney Antibodies  >7 publications with MTDH and Kidney
 Nerve Antibodies  >6 publications with MTDH and Nerve
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000