SKI Antibody – Mouse Monoclonal

SKI: May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. Belongs to the SKI family.

Protein type: Oncoprotein; Ubiquitin conjugating system; Transcription, coactivator/corepressor; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: nucleoplasm; nuclear body; centrosome; transcription factor complex; PML body; protein complex; transcriptional repressor complex; cytoplasm; nucleus

Molecular Function: protein domain specific binding; histone deacetylase inhibitor activity; protein binding; zinc ion binding; ubiquitin protein ligase binding; chromatin binding; SMAD binding; transcription corepressor activity; protein kinase binding

Biological Process: somatic stem cell maintenance; cell motility involved in cell locomotion; skeletal muscle fiber development; negative regulation of transcription from RNA polymerase II promoter; palate development; negative regulation of BMP signaling pathway; BMP signaling pathway; regulation of apoptosis; nose morphogenesis; negative regulation of cell proliferation; transforming growth factor beta receptor signaling pathway; negative regulation of osteoblast differentiation; positive regulation of Wnt receptor signaling pathway; positive regulation of DNA binding; embryonic limb morphogenesis; transcription initiation from RNA polymerase II promoter; camera-type eye development; negative regulation of histone deacetylation; transcription, DNA-dependent; olfactory bulb development; myotube differentiation; myelination in the peripheral nervous system; cell proliferation; negative regulation of activin receptor signaling pathway; camera-type eye morphogenesis; negative regulation of fibroblast proliferation; retina development in camera-type eye; neural tube closure; gene expression; lens morphogenesis in camera-type eye; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; anterior/posterior axis specification

Disease: Shprintzen-goldberg Craniosynostosis Syndrome