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EIF2S3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246015

MBS246015 is an antibody targeting EIF2S3. Also known as Mouse Monoclonal [clone 1H3] (IgG2a,k) to Human EIF2S3 / EIF2G. Reactive in Human. Host: Mouse. More details

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Testing Data View PDF
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Product Overview

Product Name
EIF2S3 / EIF2G, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 1H3] (IgG2a,k) to Human EIF2S3 / EIF2G
Product Gene Name
anti-EIF2S3 antibody
Product Synonym Gene Name
EIF2G
Product Synonym Names
Anti-EIF2S3 / EIF2G Antibody (clone 1H3) IHC-plus; EIF2S3; EIF-2-gamma X; EIF2; EIF2gamma; EIF-2gA; EIF-2gX; EIF2G; Human EIF2S3; EIF2G
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
1H3
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.4. Sourced in Ascites.
Purity/Purification
Protein A Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human EIF2S3 / EIF2G
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
51,109 Da
OMIM
300161
3D Structure
ModBase 3D Structure for P41091
Target Species
Human
Immunogen Description
Recombinant protein
Immunogen Species
EIF2S3/EIF2G antibody was raised against Human.
Immunogen Type
Recombinant protein
Applications Tested/Suitable for anti-EIF2S3 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-EIF2S3 antibody
ELISA, IHC-P (5 ug/ml), WB
Usage: Sandwich ELISA: Recombinant protein. Western Blot: Recombinant protein.

Immunohistochemistry (IHC) of anti-EIF2S3 antibody

Anti-EIF2S3 / EIF2G antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-EIF2S3 Monoclonal Antibody – Cat# MBS246015

ELISA (EIA) of anti-EIF2S3 antibody

Detection limit for recombinant GST tagged EIF2S3 is 0.3 ng/ml as a capture antibody.
Mouse Anti-EIF2S3 Monoclonal Antibody, ELISA (EIA) – Cat# MBS246015

Other Notes

Small volumes of anti-EIF2S3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EIF2S3. It may not necessarily be applicable to this product.

NCBI GI #
4503507
NCBI GeneID
1968
NCBI Accession #
NP_001406.1
UniProt Primary Accession #
P41091
UniProt Secondary Accession #
B5BTZ4
UniProt Related Accession #
P41091
GenBank Nucleotide #
NM_001415.3
NCBI Official Full Name
eukaryotic translation initiation factor 2 subunit 3
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
NCBI Official Symbol
EIF2S3
NCBI Official Synonym Symbols
EIF2; EIF2G; eIF-2gA; EIF2gamma
UniProt Protein Name
Eukaryotic translation initiation factor 2 subunit 3
UniProt Synonym Protein Names
Eukaryotic translation initiation factor 2 subunit gamma X; eIF-2-gamma X; eIF-2gX
Protein Family
Eukaryotic translation initiation factor
UniProt Gene Name
EIF2S3
UniProt Synonym Gene Names
EIF2G; eIF-2-gamma X; eIF-2gX
UniProt Entry Name
IF2G_HUMAN
NCBI Protein Information
eukaryotic translation initiation factor 2 subunit 3; eIF-2gX; eIF-2-gamma X; eukaryotic translation initiation factor 2G; eukaryotic translation initiation factor 2 subunit gamma X

NCBI Summary for EIF2S3

The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010]

UniProt Comments for EIF2S3

eIF2-gamma: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Protein type: Translation initiation; Translation

Chromosomal Location of Human Ortholog: Xp22.2-p22.1

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: GTPase activity; protein binding; GTP binding; translation factor activity, nucleic acid binding; translation initiation factor activity

Biological Process: cellular protein metabolic process; translation; translational initiation; gene expression
Show more

Research Articles on EIF2S3

1. The human X-chromosomal neurological disorder characterized by intellectual disability and microcephaly is caused by a missense mutation in eIF2gamma (encoded by EIF2S3), the core subunit of the heterotrimeric eIF2 complex.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-EIF2S3 antibody

 Products by Pathway  Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
 Formation Of The Ternary Complex, And Subsequently, The 43S Complex Pathway antibodies  Formation Of The Ternary Complex, And Subsequently, The 43S Complex Pathway Diagram
 GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway antibodies  GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 L13a-mediated Translational Silencing Of Ceruloplasmin Expression Pathway antibodies  L13a-mediated Translational Silencing Of Ceruloplasmin Expression Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram

Diseases associated with anti-EIF2S3 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >2 publications with EIF2S3 and Adenocarcinoma
 Nervous System Diseases Antibodies  >1 publications with EIF2S3 and Nervous System Diseases
 Urogenital Abnormalities Antibodies  >1 publications with EIF2S3 and Urogenital Abnormalities
 Neurobehavioral Manifestations Antibodies  >1 publications with EIF2S3 and Neurobehavioral Manifestations
 Disorders of Sex Development Antibodies  >1 publications with EIF2S3 and Disorders of Sex Development

Organs/Tissues associated with anti-EIF2S3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with EIF2S3 and Blood
 Liver Antibodies  >1 publications with EIF2S3 and Liver
 Testis Antibodies  >1 publications with EIF2S3 and Testis
 Brain Antibodies  >1 publications with EIF2S3 and Brain
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