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SETD7 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246038

MBS246038 is an antibody targeting SETD7. Also known as Mouse Monoclonal [clone 5B4] (IgG2a,k) to Human SETD7 / SET7. Reactive in Human. Host: Mouse. More details

$650 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SETD7 / SET7, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 5B4] (IgG2a,k) to Human SETD7 / SET7
Product Gene Name
anti-SETD7 antibody
Product Synonym Gene Name
SET7
Product Synonym Names
Anti-SETD7 / SET7 Antibody (clone 5B4) IHC-plus; SETD7; Lysine N-methyltransferase 7; KIAA1717; SET9; H3-K4-HMTase SETD7; KMT7; SET7; SET7/9; Human SETD7; SET7
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
5B4
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.2
Purity/Purification
Protein A Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human SET7
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
40,721 Da
OMIM
606594
3D Structure
ModBase 3D Structure for Q8WTS6
Target Species
Human
Immunogen Description
SET7 (NP_085151, 257 a.a. ~ 367 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen
SETD7 / SET7 antibody was raised against sET7 (NP_085151, 257 a.a. ~ 367 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Applications Tested/Suitable for anti-SETD7 antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-SETD7 antibody
ELISA, IF (10 ug/ml), IHC-P (5 ug/ml), WB
Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Western Blot: Cell lysate, Recombinant protein.

Immunohistochemistry (IHC) of anti-SETD7 antibody

Anti-SETD7 / SET7 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
Mouse Anti-SETD7 Monoclonal Antibody – Cat# MBS246038

Immunofluorescence (IF) of anti-SETD7 antibody

Immunofluorescence of monoclonal antibody to SET7 on HeLa cell. [antibody concentration 10 ug/ml]
Mouse Anti-SETD7 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS246038

Western Blot (WB) of anti-SETD7 antibody

SET7 monoclonal antibody (M01), clone 5B4 Western blot of SET7 expression in Jurkat.
Mouse Anti-SETD7 Monoclonal Antibody, Western Blot (WB) – Cat# MBS246038

Other Notes

Small volumes of anti-SETD7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SETD7. It may not necessarily be applicable to this product.

NCBI GI #
18139549
NCBI GeneID
80854
NCBI Accession #
NP_085151.1
UniProt Primary Accession #
Q8WTS6
UniProt Secondary Accession #
Q0VAH3; Q4W5A9; Q9C0E6; B5WWL3
UniProt Related Accession #
Q8WTS6
GenBank Nucleotide #
NM_030648.2
NCBI Official Full Name
histone-lysine N-methyltransferase SETD7
NCBI Official Synonym Full Names
SET domain containing (lysine methyltransferase) 7
NCBI Official Symbol
SETD7
NCBI Official Synonym Symbols
KMT7; SET7; SET9; SET7/9
UniProt Protein Name
Histone-lysine N-methyltransferase SETD7
UniProt Synonym Protein Names
Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7/9
Protein Family
Histone-lysine N-methyltransferase
UniProt Gene Name
SETD7
UniProt Synonym Gene Names
KIAA1717; KMT7; SET7; SET9; H3-K4-HMTase SETD7
UniProt Entry Name
SETD7_HUMAN
NCBI Protein Information
histone-lysine N-methyltransferase SETD7; H3-K4-HMTase SETD7; lysine N-methyltransferase 7; SET domain-containing protein 7; histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase

UniProt Comments for SETD7

SETD7: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Interacts with IPF1/PDX-1. Widely expressed. Expressed in pancreatic islets. Belongs to the histone-lysine methyltransferase family. SET7 subfamily.

Protein type: Amino Acid Metabolism - lysine degradation; Methyltransferase; Methyltransferase, protein lysine; EC 2.1.1.43

Chromosomal Location of Human Ortholog: 4q28

Cellular Component: nucleoplasm; nucleolus; chromosome

Molecular Function: protein binding; p53 binding; protein-lysine N-methyltransferase activity; histone-lysine N-methyltransferase activity

Biological Process: establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; peptidyl-lysine di-methylation; peptidyl-lysine mono-methylation; chromatin modification; response to DNA damage stimulus
Show more

Research Articles on SETD7

1. Set7-dependent gene expression changes that occurred independent of H3K4m1 may involve transcription factor lysine methylation events.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SETD7 antibody

 Reference Product  PubMed Publications
 RELA antibody  >4 publications with SETD7 and RELA
 TAF10 antibody  >2 publications with SETD7 and TAF10
 E2F1 antibody  >2 publications with SETD7 and E2F1
 SETD1A antibody  >1 publications with SETD7 and SETD1A
 TP53 antibody  >1 publications with SETD7 and TP53

Pathways associated with anti-SETD7 antibody

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 PKMTs Methylate Histone Lysines Pathway antibodies  PKMTs Methylate Histone Lysines Pathway Diagram
 P53 Pathway antibodies  P53 Pathway Diagram

Diseases associated with anti-SETD7 antibody

 Disease Name  Pubmed Publications
 Hyperglycemia Antibodies  >7 publications with SETD7 and Hyperglycemia
 Inflammation Antibodies  >4 publications with SETD7 and Inflammation
 Disease Models, Animal Antibodies  >4 publications with SETD7 and Disease Models, Animal
 Necrosis Antibodies  >3 publications with SETD7 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >2 publications with SETD7 and Cell Transformation, Neoplastic
 Fibrosis Antibodies  >1 publications with SETD7 and Fibrosis
 Kidney Diseases Antibodies  >1 publications with SETD7 and Kidney Diseases
 Fatty Liver Antibodies  >1 publications with SETD7 and Fatty Liver

Organs/Tissues associated with anti-SETD7 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >7 publications with SETD7 and Vascular
 Heart Antibodies  >7 publications with SETD7 and Heart
 Liver Antibodies  >4 publications with SETD7 and Liver
 Blood Antibodies  >4 publications with SETD7 and Blood
 Brain Antibodies  >4 publications with SETD7 and Brain
 Muscle Antibodies  >3 publications with SETD7 and Muscle
 Bone Antibodies  >2 publications with SETD7 and Bone
 Lung Antibodies  >2 publications with SETD7 and Lung
 Kidney Antibodies  >2 publications with SETD7 and Kidney
 Nerve Antibodies  >2 publications with SETD7 and Nerve
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